The delivery of medical care relies on efective, succinct, and ongoing communication between healthcare providers, called handofs. Handofs involve the transfer of professional responsibility and accountability for aspects of care for patients to another clinician or clinical team on a temporary or permanent basis. Handofs have the potential for deleterious clinical impact if inadequately done. Only recently has data become available that demonstrate improvements in handofs reduce the rate of subsequent clinical care error. This clinical vignete and subsequent discussion focuses on physician, particularly the resident physician in training, transfer of care: handof complications, barriers to efective handofs, regulatory agencies' input on handof improvement, standardization of the handof process, assessment of the quality of handof, handof error avoidance, and improving the quality of handof.