Morning plasma cortisol is low among obese women with polycystic ovary syndrome

Shabir, Iram; Ganie, Mohd Ashraf; Praveen, Edavan Pulikkanath; Khurana, Madan Lal; John, Jomimol; Gupta, Nidhi; Kumar, Guresh; Ammini, AC

doi:10.3109/09513590.2013.829449

Cited by 12 publications

(2 citation statements)

References 20 publications

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“…We found higher levels of basal salivary cortisol in nonobese PCOS women compared with obese PCOS and nonobese controls. Our results are partly in accordance with a recent study where lean PCOS had higher basal cortisol levels compared to obese PCOS and lean controls, although LH levels did not show similar pattern [21]. …”

Section: Discussionsupporting

confidence: 92%

Adrenocortical Production Is Associated with Higher Levels of Luteinizing Hormone in Nonobese Women with Polycystic Ovary Syndrome

Tock

Carneiro

Pereira

et al. 2014

International Journal of Endocrinology

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Objective. Insulin resistance (IR) and ovarian and adrenal hyperandrogenism are a common finding in women with polycystic ovary syndrome (PCOS). The aim of the present study was to access possible differences in insulin resistance, gonadotropins, and androgens production in obese and nonobese PCOS women. Study Design. We studied 37 PCOS women (16 nonobese and 21 obese) and 18 nonobese controls. Fasting glucose, insulin, androgens, and gonadotropins levels were determined. Salivary cortisol was measured basal and in the morning after dexamethasone (DEX) 0.25 mg. Results. Nonobese PCOS women showed higher basal salivary cortisol and serum dehydroepiandrosterone sulfate and luteinizing hormone (LH) levels than controls and obese PCOS. These hormones levels did not differ between the obese and control groups. After DEX administration no differences were found between the three groups. In PCOS women, salivary cortisol levels showed negative correlation with BMI (r = −0.52; P = 0.001) and insulin (r = −0.47; P = 0.003) and positive correlation with LH (r = 0.40; P = 0.016). Conclusion. Our results show an increased adrenocortical production in nonobese PCOS women, not related to IR and associated with a normal hypothalamic-pituitary-adrenal suppression. Higher LH levels might be involved in this event.

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Section: Discussionsupporting

confidence: 92%

Adrenocortical Production Is Associated with Higher Levels of Luteinizing Hormone in Nonobese Women with Polycystic Ovary Syndrome

Tock

Carneiro

Pereira

et al. 2014

International Journal of Endocrinology

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“…Standardized evaluation of HPA axis activity in future studies would greatly enhance the reliability and value of future meta-analyses. Regarding gender, the majority of the studies (fifteen of them) contained data regarding morning blood cortisol or 24-h urinary free cortisol of women [25, 26, 28, 33–35, 37–39, 41, 44, 46, 47, 49, 50], four of which also tested the correlation between BMI and cortisol [33, 44, 46, 50]. Two of them found some association between obesity and morning blood cortisol or urinary free cortisol [44, 46].…”

Section: Discussionmentioning

confidence: 99%

In Obesity, HPA Axis Activity Does Not Increase with BMI, but Declines with Aging: A Meta-Analysis of Clinical Studies

et al. 2016

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BackgroundObesity is one of the major public health challenges worldwide. It involves numerous endocrine disorders as etiological factors or as complications. Previous studies strongly suggested the involvement of the hypothalamic-pituitary-adrenal (HPA) axis activity in obesity, however, to date, no consistent trend in obesity-associated alterations of the HPA axis has been identified. Aging has been demonstrated to aggravate obesity and to induce abnormalities of the HPA axis. Thus, the question arises whether obesity is correlated with peripheral indicators of HPA function in adult populations.ObjectivesWe aimed to meta-analyze literature data on peripheral cortisol levels as indicators of HPA activity in obesity during aging, in order to identify possible explanations for previous contradictory findings and to suggest new approaches for future clinical studies.Data Sources3,596 records were identified through searching of PubMed, Embase and Cochrane Library Database. Altogether 26 articles were suitable for analyses.Study Eligibility CriteriaEmpirical research papers were eligible provided that they reported data of healthy adult individuals, included body mass index (BMI) and measured at least one relevant peripheral cortisol parameter (i.e., either morning blood cortisol or 24-h urinary free cortisol).Statistical MethodsWe used random effect models in each of the meta-analyses calculating with the DerSimonian and Laird weighting methods. I-squared indicator and Q test were performed to assess heterogeneity. Meta-regression was applied to explore the effect of BMI and age on morning blood and urinary free cortisol levels. To assess publication bias Egger’s test was used.ResultsObesity did not show any correlation with the studied peripheral cortisol values. On the other hand, peripheral cortisol levels declined with aging within the obese, but not in the non-obese groups.ConclusionsOur analysis demonstrated that obesity or healthy aging does not lead to enhanced HPA axis activity, peripheral cortisol levels rather decline with aging.

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Acne

Layton,

Eady,

Zouboulis

2016

Rook's Textbook of Dermatology, Ninth Edition

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Acne represents the commonest inflammatory dermatosis seen worldwide and is the leading reason for seeing a dermatologist; a number of acne variants are described. In children, these include neonatal, infantile, mid‐childhood and prepubertal acne. Acne fulminans and acne conglobata represent severe but rare forms. Predisposing factors may be implicated in acneform dermatoses; these include medications, occupational and environmental triggers, cosmetics, systemic diseases and syndromes. This chapter describes all clinical variants and provides evidence‐based or expert opinion on management.

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Morning plasma cortisol is low among obese women with polycystic ovary syndrome

Cited by 12 publications

References 20 publications

Adrenocortical Production Is Associated with Higher Levels of Luteinizing Hormone in Nonobese Women with Polycystic Ovary Syndrome

Adrenocortical Production Is Associated with Higher Levels of Luteinizing Hormone in Nonobese Women with Polycystic Ovary Syndrome

In Obesity, HPA Axis Activity Does Not Increase with BMI, but Declines with Aging: A Meta-Analysis of Clinical Studies

Acne

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