Morning Serum Cortisol Is Uniquely Associated with Cardiometabolic Risk Independent of Body Composition in Latino Adolescents

Toledo-Corral, Claudia M.; Ding, Li; Morales, Jeremy C; Chapman, Tiffany M; Romero, Melyssa B; Weigensberg, Marc J.

doi:10.1089/met.2022.0091

Cited by 2 publications

(1 citation statement)

References 38 publications

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“…202 Emotional stress is also associated with a metabolically unhealthy phenotype. 203 This may be mediated through increased cortisol secretion during stress, 204 which can cause deterioration in metabolic health through its metabolic effects 205,206 as well as through the increased preference of unhealthy food choices. 207 Age-related decline in testosterone in males and menopause-related decline in oestrogen in females may also contribute to the transition to an unhealthy phenotype in view of the known beneficial metabolic effects of these sex hormones.…”

Section: Zhang Et Al Reported the Highest Transitions From Muhnw Tomentioning

confidence: 99%

Phenotyping obesity: A focus on metabolically healthy obesity and metabolically unhealthy normal weight

Agius,

Pace,

Fava

2023

Diabetes Metabolism Res

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Over the past 4 decades, research has shown that having a normal body weight does not automatically imply preserved metabolic health and a considerable number of lean individuals harbour metabolic abnormalities typically associated with obesity. Conversely, excess adiposity does not always equate with an abnormal metabolic profile. In fact, evidence exists for the presence of a metabolically unhealthy normal weight (MUHNW) and a metabolically healthy obese (MHO) phenotype. It has become increasingly recognised that different fat depots exert different effects on the metabolic profile of each individual by virtue of their location, structure and function, giving rise to these different body composition phenotypes. Furthermore, other factors have been implicated in the aetiopathogenesis of the body composition phenotypes, including genetics, ethnicity, age and lifestyle/behavioural factors. Even though to date both MHO and MUHNW have been widely investigated and documented in the literature, studies report different outcomes on long‐term cardiometabolic morbidity and mortality. Future large‐scale, observational and population‐based studies are required for better profiling of these phenotypes as well as to further elucidate the pathophysiological role of the adipocyte in the onset of metabolic disorders to allow for better risk stratification and a personalised treatment paradigm.

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Section: Zhang Et Al Reported the Highest Transitions From Muhnw Tomentioning

confidence: 99%

Phenotyping obesity: A focus on metabolically healthy obesity and metabolically unhealthy normal weight

Agius,

Pace,

Fava

2023

Diabetes Metabolism Res

View full text Add to dashboard Cite

show abstract

Effect of timing of administration on lipid-lowering efficacy of statins-meta-analysis

Wang,

Quan,

Wang

et al. 2023

Eur J Clin Pharmacol

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Morning Serum Cortisol Is Uniquely Associated with Cardiometabolic Risk Independent of Body Composition in Latino Adolescents

Cited by 2 publications

References 38 publications

Phenotyping obesity: A focus on metabolically healthy obesity and metabolically unhealthy normal weight

Phenotyping obesity: A focus on metabolically healthy obesity and metabolically unhealthy normal weight

Effect of timing of administration on lipid-lowering efficacy of statins-meta-analysis

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