Moroccan medicinal plants traditionally used for the treatment of skin diseases: From ethnobotany to clinical trials

Ajjoun, Mohammed; Kharchoufa, Loubna; Merrouni, Ilyass Alami; Elachouri, Mostafa

doi:10.1016/j.jep.2022.115532

Cited by 123 publications

(28 citation statements)

References 255 publications

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“…In fact, it is suggested that the wide availability of wild Lamiaceae to the Iberian people communities, their appealing flowers, and their use for pleasant essential oil production has prompted their massive use in folk medicine ever since [ 18 , 19 ]. Notwithstanding, the medicinal importance of such a group of plants is equally denoted in other circum-Mediterranean territories [ 6 , 13 , 21 ]. Therefore, in this work, we reviewed Iberian ethnobotanical surveys published between 2000 and 2022.…”

Section: Traditional Use Of Lamiaceae In the Iberian Peninsulamentioning

confidence: 99%

“…In traditional medicine, M. vulgare ( Figure 1 B) is mostly used to treat gastrointestinal and respiratory diseases [ 90 ], and also for several skin conditions, either in the Iberian Peninsula [ 20 ] or in other countries of the Mediterranean region [ 3 , 13 ]. Interestingly, the scientific-based wound healing activity of this Lamiaceae has received some attention in the Mediterranean basin [ 3 , 7 , 23 ].…”

Section: Pharmacological Wound Healing Evidence Of Iberian Lamiaceaementioning

confidence: 99%

“…In this sense, the search for pharmacological evidence and scientific validation of traditional practices using medicinal plants for dermatological conditions has been the aim of numerous surveys in distinct geographical regions, such as Italy [ 11 ], Saudi Arabia [ 12 ], the Balkans [ 9 ], Morocco [ 6 , 13 ], and noteworthy the Iberian Peninsula [ 14 , 15 ]. In particular, the traditional use of the family Lamiaceae has been highlighted in several ethnobotanical assays carried out within the Iberian Peninsula [ 16 , 17 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

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Exploring Iberian Peninsula Lamiaceae as Potential Therapeutic Approaches in Wound Healing

et al. 2023

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Skin tissue has a crucial role in protecting the human body from external harmful agents, preventing wounds that frequently demand proper healing approaches. The ethnobotanical knowledge of specific regions with further investigation on their medicinal plants has been paramount to create new and effective therapeutical agents, including for dermatological purposes. This review attempts, for the first time, to investigate the traditional applications of Lamiaceae medicinal plants that are already used by local communities in the Iberian Peninsula in wound healing. Henceforward, Iberian ethnobotanical surveys were reviewed, and the information about the traditional wound healing practices of Lamiaceae was comprehensively summarized. Afterwards, the scientific validation of each Lamiaceae species was exhaustively checked. From this, eight out of twenty-nine Lamiaceae medicinal plants were highlighted by their wound-related pharmacological evidence and are in-depth presented in this review. We suggest that future studies should focus on the isolation and identification of the active molecules of these Lamiaceae, followed by robust clinical trials that may confirm the security and effectiveness of such natural-based approaches. This will in turn pave the way for more reliable wound healing treatments.

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Section: Traditional Use Of Lamiaceae In the Iberian Peninsulamentioning

confidence: 99%

Section: Pharmacological Wound Healing Evidence Of Iberian Lamiaceaementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Exploring Iberian Peninsula Lamiaceae as Potential Therapeutic Approaches in Wound Healing

et al. 2023

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“…A ccording to the World Health Organisation's estimate, the primary health care needs of 80% of the population in some developing countries is covered by the traditional medicine, Asia, Latin America and Africa, especially in rural areas due to the proximity and accessibility of this type of care, the low purchasing power of families, and the lack of access to modern medicine for these populations (WHO, 2013) of which we find the Moroccan population using phytotherapy for their diseases (Fatiha et al, 2017;Ajjoun et al, 2022). et al, 2019).…”

Section: Introductionmentioning

confidence: 97%

Acute Oral Toxicity and Neurobehavioral Effects of Salvia officinalis Essential Oil in Female Wistar Rats

Rhaimi¹,

Brikat²,

Lamtai³

et al. 2023

AAVS

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In recent years, Salvia officinalis has been a subject of intensive studies to document its traditional use and to find new biological effects. Numerous studies have been carried out in this contest and most of them were interested in Salvia officinalis extract' effects and not many explored the biological activities of Salvia officinalis essential oil, especially the ones related to the central nervous system. The Purpose of this study is to investigate the acute toxicity of salvia officinalis essential oil in female Wistar rats, and to explore the antidepressant-like and anxiolytic-like effects and memory enhancing of the safe dose of this essential oil. In this experiment, salvia officinalis essential oil was administered once by oral gavage to four groups of female Wistar rats (n=6) at three different doses; 1000, 2000 and 3000 mg/kg. During 14 days after dosing, a follow-up was carried out for the mortality, food and water consumption, body weight changing and clinical signs. Biochemical parameters and organ weight were also examined. The behavior of rats was evaluated at the end of the experiment for anxiety-like and depression-like and memory. Accordingly, treatment with salvia officinalis essential oil at a dose of 2000 mg/kg showed no mortality or clinical signs, nor any changes in body, organ weights or biochemical parameters, except for mortality induced in one female rat treated with 2000 mg/kg. Furthermore, the LD50 (50% lethal dose) was determined at 3000 mg/kg. Based on these findings, the no observed adverse effect level of salvia officinalis essential oil was established to be 1000 mg/kg. Evaluation of the effect of this therapeutic dose revealed a clear anxiolytic and antidepressant actions and improved memory functioning in female Wistar rats. In conclusion, salvia officinalis essential oil produce neuroprotective activity in female rats.

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“…E. officinarum subsp. echinus has also been reported in the treatment of wounds, skin infections and abscesses in diverse places in Morocco [ 16 , 17 , 18 ] and by the Sahrawi refugees in Algerian refugee camps [ 19 ]. Although Idm’hand et al [ 18 ] had noted the utilization of that species in the treatment of skin diseases, their work indicated that the specific treatment purpose of E. officinarum subsp.…”

Section: Introductionmentioning

confidence: 99%

Biological Properties of Latex, Aqueous Extracts and Bee Products of Euphorbia officinarum L.: A Short Review

2022

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Euphorbia officinarum L. is a Moroccan endemic plant known as “Tikiout” and “Daghmus” that can also be found in Mauritania, Western Sahara, and Algeria. In the present review, “Euphorbia officinarum”, “metabolites” “hemisynthesis” were the keywords used for the research in the Web search engine Google Scholar and in the database Web of Science. Triterpenes, phytosterols and ingol diterpenes were isolated and identified in the latex of Moroccan E. officinarum. More than sixty triterpenes were obtained by hemisynthesis from natural triterpenes. Some of these derivatives had insecticidal and antimicrobial activity (phytopathogenic bacteria). The total phenol content and the antioxidant and anti-a-glucosidase activities were dependent on the time and temperature of extractions and also on the plant solvent ratio. The antioxidant activity of monofloral honey of E. officinarum origin was attributed to the phenol fraction (this fraction, previously isolated from honey samples, had better activity than the entire honey).

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Moroccan medicinal plants traditionally used for the treatment of skin diseases: From ethnobotany to clinical trials

Cited by 123 publications

References 255 publications

Exploring Iberian Peninsula Lamiaceae as Potential Therapeutic Approaches in Wound Healing

Exploring Iberian Peninsula Lamiaceae as Potential Therapeutic Approaches in Wound Healing

Acute Oral Toxicity and Neurobehavioral Effects of Salvia officinalis Essential Oil in Female Wistar Rats

Biological Properties of Latex, Aqueous Extracts and Bee Products of Euphorbia officinarum L.: A Short Review

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