MORPHEA‐LIKE REACTION FROM VITAMIN K₁

Update on morphea

“…There are also reports of morphea lesions occurring after vitamin B 12 and vitamin K injections (Texier disease). [29][30][31][32] The trauma of the injection may induce an overexuberant healing process that results in unchecked fibrosis.…”

Drug-induced morphea: Report of a case induced by balicatib and review of the literature

“…3,16 Finally, vitamin K 1 and vitamin B 12 may induce morphea-like lesions locally, possibly in relation to a toxic effect of the vehicle (oilsoluble preparation) or the preservative (benzyl alcohol), or to a hypersensitivity reaction. [17][18][19] We report herein the appearance of morphea-like lesions after therapy with a cathepsin K inhibitor. Cathepsin K belongs to a group of cysteine proteases that were long believed to be primarily involved in intracellular protein turnover, but now known to also be active in the extracellular environment.…”

“…In two cases bullous lesions were present. 14,15 Sclerotic lesions were usually preceded by erythematous lesions, variably itchy (5/15) 11,12,15,19,20 or associated with tingling or burning sensation (2/15). 9,14 Cases associated with L-5-hydroxytryptophane and carbidopa showed hypereosinophilia 14,15 ; some patients with bleomycin-associated scleroderma showed Raynaud's phenomenon, sclerodactyly, cutaneous calcinosis, lung involvement, and weakly positive reaction for antinuclear antibodies.…”

“…Vitamin Ke, vitamin B 12 e, and pentazocine-induced morphea was always limited at site of injection. [16][17][18][19][20] Morphology of lesions was that of typical plaque morphea. In two cases bullous lesions were present.…”

Vitamin B12-Associated Localized Scleroderma and Its Treatment

“…1 Sclerodermoid reactions, sometimes referred to as pseudoscleroderma, are acquired cutaneous reactions that clinically and histologically resemble localized scleroderma (morphea). Drugs that have been implicated in sclerodermoid reactions include vitamin B12, 2,3 vitamin K (Texier's disease), [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] and pentazocine. 20,21 Vitamin B12 sclerodermoid reactions have been noted in Europe, but to our knowledge have not been reported elsewhere.…”