Morpheiform sarcoidosis as atypical manifestation of sarcoidosis. Review of the literature and differential diagnosis

Castellanos-González, María; Talavera, María Remedios Picazo

doi:10.1016/j.medcle.2016.10.005

Cited by 3 publications

(9 citation statements)

References 18 publications

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“…Including our patient, only 9 cases have been reported in the literature. [3][4][5][6][7][8] Of the 9 patients, the majority (7 of 9) are women. Five cases occurred in White patients and 4 in Black patients.…”

Section: Discussionmentioning

confidence: 99%

“…The median age (interquartile range) at the time of diagnosis was 58 years (41-71 years). [3][4][5][6][7][8] Although most of the cases occurred later in life, 1 was reported in a 17-year-old patient. 4 The morpheaform eruption was the initial manifestation of sarcoidosis in 7 patients and occurred years after the diagnosis of systemic sarcoidosis in 2 patients.…”

Section: Discussionmentioning

confidence: 99%

“…The distribution and number of lesions were also heterogeneous. [3][4][5][6][7][8] Two had a linear eruption, resembling linear morphea. 5,7 Cases of both skinlimited morpheaform sarcoidosis and morpheaform lesions in the context of systemic sarcoidosis have been reported.…”

Section: Discussionmentioning

confidence: 99%

“…5,7 Cases of both skinlimited morpheaform sarcoidosis and morpheaform lesions in the context of systemic sarcoidosis have been reported. [3][4][5][6][7][8] Our patient presented with skin-limited morpheaform sarcoidosis. For patients with skin-limited disease, the risk for the development of systemic involvement is unknown.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 Several cases support the effectiveness of hydroxychloroquine in treating morpheaform sarcoidosis. [3][4][5][6][7][8] In addition to hydroxychloroquine, our patient is maintained on methotrexate and has had continued resolution of symptoms.…”

Section: Discussionmentioning

confidence: 99%

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Morpheaform sarcoidosis: A case presentation of an uncommon cutaneous manifestation of sarcoidosis

2021

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Morpheaform sarcoidosis: A case presentation of an uncommon cutaneous manifestation of sarcoidosis

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Cutaneous sarcoidosis mimicking linear morphea: a rare case of morpheaform sarcoidosis

Gowda V.M.,

Singh,

Dayal

et al. 2023

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Rituximab‐induced mucosal pyogenic granuloma

Boyvadoglu,

Uzun,

Erkilic

et al. 2023

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occasional foreign body giant cell and sclerosis (Figure 2b). Fite-Faraco for atypical mycobacteria and PAS staining for fungus were negative. Thus, clinically mimicking linear morphea and histopathology eliciting sarcoidosis made our case unique.Hence, a definitive diagnosis of morpheaform sarcoidosis was made based on clinical, dermoscopy, and histopathological findings. The patient improved with oral corticosteroids, weekly methotrexate injections, and topical tacrolimus. Sarcoidosis is a multisystem disease characterized by granulomatous inflammation of unknown etiology commonly affecting lungs and skin. 1 A review of literature showed eight cases of morpheaform sarcoidosis to date. [1][2][3][4][5][6] Biopsy findings were consistent with findings of cutaneous sarcoidosis. ACE levels were elevated in four patients while ANA was positive in two patients. There were five patients with pulmonary involvement with abnormal chest x-ray findings and restrictive patterns in pulmonary function tests. Treatment given was oral and topical corticosteroid mainly. [1][2][3][4][5][6] In our present case, clinical lesions were consistent with linear morphea and were correlated with dermal sclerosis on biopsy. Dermal sclerosis could be because of the release of number of cytokines by activated T-cells and macrophages during the process of formation of granuloma. 1 Another feature in biopsy was the presence of non-caseating granuloma consistent with the diagnosis of sarcoidosis, hence leading us to the diagnosis of morpheaform sarcoidosis. In our present case, we have evaluated dermoscopically, which has not been mentioned in earlier reports.Herein, we are reporting a case of morpheaform sarcoidosis mimicking linear morphea over the right upper and lower limb in a 16-year-old-young girl. Our case report sensitizes the dermatologist fraternity regarding consideration of sarcoidosis in the differential diagnosis of indurated skin lesions and evaluation accordingly to prevent complications of untreated sarcoidosis.

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Morpheiform sarcoidosis as atypical manifestation of sarcoidosis. Review of the literature and differential diagnosis

Cited by 3 publications

References 18 publications

Morpheaform sarcoidosis: A case presentation of an uncommon cutaneous manifestation of sarcoidosis

Morpheaform sarcoidosis: A case presentation of an uncommon cutaneous manifestation of sarcoidosis

Cutaneous sarcoidosis mimicking linear morphea: a rare case of morpheaform sarcoidosis

Rituximab‐induced mucosal pyogenic granuloma

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