Morphine Antinociception Restored by Use of Methadone in the Morphine-Resistant Inflammatory Pain State

Watanabe, Chizuko; Komiyama, Asami; Yoshizumi, Masaru; Sakurada, Shinobu; Mizoguchi, Hirokazu

doi:10.3389/fphar.2020.593647

Cited by 5 publications

(2 citation statements)

References 20 publications

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“…However, the use of methadone in burn patients is limited to retrospective studies [19]. The data clearly show that opioid use requires careful assessment of the patient's tolerance and ongoing titration of these medications, as the reason varies in different patients [8,9,[20][21][22]. In burn patients, pharmacogenetic polymorphism has been clearly associated with differences in opioid use [23,24].…”

Section: Discussionmentioning

confidence: 99%

Analgesic Efficacy of Oxycodone in Postoperative Dressings after Surgical Treatment of Burn Wounds: A Randomised Controlled Trial

Kowalski,

Leppert,

Domagalska

et al. 2024

JCM

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Introduction: This study aimed to assess the analgesic efficacy of oxycodone at doses of 10 mg and 20 mg in dressings after surgery of burn wounds. Material and Methods: Twenty adult patients who underwent surgical treatment of third-degree burn wounds under general anaesthesia were included. Burn wounds were treated with dressings, to which oxycodone was added at 20 mg in Group 1 and 10 mg in Group 2. After the surgery, plasma oxycodone and noroxycodone concentrations were assayed, and pain intensity was assessed with Numerical Rating Scale (NRS). Results: In Group 1, no patient reported pain; in Group 2, four patients reported pain. The pain intensity, according to NRS, was 1–8. Plasma concentration of oxycodone in the blood serum was in the range of 1.24–3.15 ng/mL and 1.09–1.28 ng/mL in Group 1 and Group 2, respectively. Noroxycodone was not detected in the plasma. Adverse effects were not observed in any of the treated patients. Conclusions: Oxycodone in dressings provides patients with adequate and safe analgesia.

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Section: Discussionmentioning

confidence: 99%

Analgesic Efficacy of Oxycodone in Postoperative Dressings after Surgical Treatment of Burn Wounds: A Randomised Controlled Trial

Kowalski,

Leppert,

Domagalska

et al. 2024

JCM

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“…This finding suggests that methadone has a low potential for inducing opioid tolerance, confirming data gathered from experimental studies. 24 …”

Section: Discussionmentioning

confidence: 99%

Methadone as First-line Opioid for the Management of Cancer Pain

et al. 2022

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Aim The aim of this study was to assess the efficacy and adverse effects of methadone when used as first-line therapy in patients that are either receiving low doses of opioids or none. Methods Patients with advanced cancer were prospectively assessed. Opioid-naive patients (L-group) were started with methadone at 6 mg/day. Patients receiving weak or other opioids in doses of <60 mg/day of OME (H-group) were started with methadone at 9 mg/day. Methadone doses were changed according to the clinical needs to obtain the most favorable balance between analgesia and adverse effects. Edmonton Symptom Asssement Score (ESAS), Memorial Delirium Assessment Score (MDAS), doses of methadone, and the use of adjuvant drugs were recorded before starting the study treatment (T0), 1 week after (T7), 2 weeks after (T14), 1 month after (T30), and 2 months after (T60). Methadone escalation index percent (MEI%) and in mg (MEImg) were calculated at T30 and T60. Results Eighty-two patients were assessed. In both groups H and L, there were significant changes in pain and symptom intensity at the different times during the study. Adverse effects as causes of drop-out were minimal. Mean MEImg was 0.09 (SD 0.28) and 0.02 (SD 0.07) at T30 and T60, respectively. MEI% was 1.01 (SD 3.08) and 0.27 (SD 0.86) at T30 and T60, respectively. Conclusion Methadone used as a first-line opioid therapy provided good analgesia with limited adverse effects and a minimal opioid-induced tolerance.

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DD04107-Derived neuronal exocytosis inhibitor peptides: Evidences for synaptotagmin-1 as a putative target

Butrón

Zamora-Carreras

Devesa

et al. 2021

Bioorganic Chemistry

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Morphine Antinociception Restored by Use of Methadone in the Morphine-Resistant Inflammatory Pain State

Cited by 5 publications

References 20 publications

Analgesic Efficacy of Oxycodone in Postoperative Dressings after Surgical Treatment of Burn Wounds: A Randomised Controlled Trial

Analgesic Efficacy of Oxycodone in Postoperative Dressings after Surgical Treatment of Burn Wounds: A Randomised Controlled Trial

Methadone as First-line Opioid for the Management of Cancer Pain

DD04107-Derived neuronal exocytosis inhibitor peptides: Evidences for synaptotagmin-1 as a putative target

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