Morphine-induced conditioned place preference in rhesus monkeys: Resistance to inactivation of insula and extinction

Wu, Xu; Zhao, Ning; Bai, Fan; Li, Chuan Yu; Liu, Ci Rong; Wei, Jing; Zong, Wei; Yang, Li; Ryabinin, Andrey E.; Yuan, Ye; Wang, Jian Hong

doi:10.1016/j.nlm.2016.04.005

Cited by 13 publications

(14 citation statements)

References 52 publications

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“…While the small sample size is a limitation of this study because the pilot studies are often used before larger studies. In addition, individual differences in rhesus monkeys have been shown with small sample sizes in previous behavioral studies53132 in order to provide a foundation for further work with larger sample populations.…”

Section: Discussionmentioning

confidence: 99%

A pilot study on transient ischemic stroke induced with endothelin-1 in the rhesus monkeys

Dai

Huang

et al. 2017

Sci Rep

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Endothelin-1 (ET-1), a vasoconstrictor, has recently been used to induce focal ischemia in rodents and marmoset monkeys. The rhesus monkey, however, has numerous advantages to the rodent and marmoset that make it a superior and irreplaceable animal model for studying stroke in the brain. In the present study, after mapping the preferred hand representation in two healthy male monkeys with intracortical micro-stimulation, ET-1 was microinjected into the contralateral motor cortex (M1) to its preferred hand. The monkeys had been trained in three manual dexterity tasks before the microinjection and were tested for these tasks following the ET-1 injection. Brain Magnetic Resonance Imaging scans were performed 1, 7, 14 and 28 days post ischemia. It was found that ET-1 impaired the manual dexterity of the monkeys in the vertical slot and rotating Brinkman board tasks 3–8 days after the injection. Brain imaging found that severe edema was present 7 days after the focal ischemia. This data suggest that ET-1 can induce transient ischemic stroke in rhesus monkey and that ET-1 induced focal ischemia in non-human primates is a potential model to study the mechanism of stroke and brain repair after stroke.

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Section: Discussionmentioning

confidence: 99%

A pilot study on transient ischemic stroke induced with endothelin-1 in the rhesus monkeys

Dai

Huang

et al. 2017

Sci Rep

Self Cite

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“…However, it is also important to note that for the tests in both discrimination procedures, the primary dependent measure of alcohol sensitivity (alcohol-appropriate responses or discrimination score) is determined prior to sucrose delivery, which makes an explanation based on altered taste or consummatory behavior less likely. Next, consideration of the known role of the IC in processing external cues associated with food or drugs (Cosme et al, 2015; Li et al, 2013; Wu et al, 2014) but see (Kusumoto-Yoshida et al, 2015; Wu et al, 2016) is important. For example, optogenetic silencing of the IC decreases cue (tone and light)-triggered food-seeking (i.e., goal-tracking) behavior (Kusumoto-Yoshida et al, 2015).…”

Section: Implications and Considerationsmentioning

confidence: 99%

“…In human brain imaging studies, drugs and drug-related cues elicit activity within the insular cortex (IC; (Droutman et al, 2015; Jasinska et al, 2014; Naqvi and Bechara, 2010) and damage to the IC in humans (Droutman et al, 2015) or high frequency stimulation (Dinur-Klein et al, 2014) disrupts nicotine addiction. In the preclinical literature, pharmacological manipulation of the IC disrupts ongoing drug self-administration (Droutman et al, 2015; Kutlu et al, 2013; Pushparaj and Le Foll, 2015), relapse-like behavior (Cosme et al, 2015; Wu et al, 2014), and conditioned place preference (Cosme et al, 2015; Droutman et al, 2015; Li et al, 2013; Wu et al, 2014 but see Wu et al, 2016). Relatedly, the IC plays a major role in interoceptive processing while IC dysfunction along with dysregulation in body awareness is commonly found in individuals with substance-use disorders (Droutman et al, 2015; Paulus and Stewart, 2014).…”

Section: Introductionmentioning

confidence: 99%

Functional role for suppression of the insular–striatal circuit in modulating interoceptive effects of alcohol

Jaramillo¹,

Agan²,

Makhijani³

et al. 2017

Addiction Biology

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The insular cortex (IC) is a region proposed to modulate, in part, interoceptive states and motivated behavior. Interestingly, IC dysfunction and deficits in interoceptive processing are often found among individuals with substance-use disorders. Furthermore, the IC projects to the nucleus accumbens core (AcbC), a region known to modulate the discriminative stimulus/interoceptive effects of alcohol and other drug-related behaviors. Therefore, the goal of the present work was to investigate the possible role of the IC ➔ AcbC circuit in modulating the interoceptive effects of alcohol. Thus, we utilized a chemogenetic technique (hM4D designer receptor activation by designer drugs) to silence neuronal activity in the IC of rats trained to discriminate alcohol (1 g/kg, IG) versus water using an operant or Pavlovian alcohol discrimination procedure. Chemogenetic silencing of the IC or IC ➔ AcbC neuronal projections resulted in potentiated sensitivity to the interoceptive effects of alcohol in both the operant and Pavlovian tasks. Together, these data provide critical evidence for the nature of the complex IC circuitry and, specifically, suppression of the insular-striatal circuit in modulating behavior under a drug stimulus control.

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“…Conditioned place preference (CPP) was developed as a technique to assess the reinforcing properties of opioid drugs (Rossi and Reid, 1976 ; Katz and Gormezano, 1979 ; Mucha and Iversen, 1984 ). Now, CPP is widely used to test context associations based on the rewarding properties of an unconditioned stimulus in many organisms including, rodents (Lu et al, 2005 ; Akbarabadi et al, 2018 ; Cunningham, 2019 ), flies (Kaun et al, 2011 ), C. elegans (Musselman et al, 2012 ; Engleman et al, 2018 ), planaria (Hutchinson et al, 2015 ; Mohammed Jawad et al, 2018 ; Adams and Byrne, 2019 ; Phelps et al, 2019 ), primates (Wang et al, 2012 ; Borges et al, 2015 ; Yan et al, 2015 ; Wu et al, 2016 ), and humans (Thewissen et al, 2006 ; Childs and De Wit, 2009 , 2013 , 2016 ). Although a widely used behavioral model, CPP is a complex behavior that incorporates Pavlovian learning, memory, and motivated behaviors.…”

Section: Introductionmentioning

confidence: 99%

Drug-Induced Conditioned Place Preference and Its Practical Use in Substance Use Disorder Research

McKendrick

Graziane

2020

Front. Behav. Neurosci.

145

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The conditioned place preference (CPP) paradigm is a well-established model utilized to study the role of context associations in reward-related behaviors, including both natural rewards and drugs of abuse. In this review article, we discuss the basic history, various uses, and considerations that are tied to this technique. There are many potential takeaway implications of this model, including negative affective states, conditioned drug effects, memory, and motivation, which are all considered here. We also discuss the neurobiology of CPP including relevant brain regions, molecular signaling cascades, and neuromodulatory systems. We further examine some of our prior findings and how they integrate CPP with self-administration paradigms. Overall, by describing the fundamentals of CPP, findings from the past few decades, and implications of using CPP as a research paradigm, we have endeavored to support the case that the CPP method is specifically advantageous for studying the role of a form of Pavlovian learning that associates drug use with the surrounding environment.

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Morphine-induced conditioned place preference in rhesus monkeys: Resistance to inactivation of insula and extinction

Cited by 13 publications

References 52 publications

A pilot study on transient ischemic stroke induced with endothelin-1 in the rhesus monkeys

A pilot study on transient ischemic stroke induced with endothelin-1 in the rhesus monkeys

Functional role for suppression of the insular–striatal circuit in modulating interoceptive effects of alcohol

Drug-Induced Conditioned Place Preference and Its Practical Use in Substance Use Disorder Research

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