Morphine-induced conditioned taste aversions: assessment of sexual dimorphism

Randall-Thompson, Jovita F.; Riley, Anthony L.

doi:10.1016/j.pbb.2003.08.010

Cited by 38 publications

(30 citation statements)

References 61 publications

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“…As in our study, sex differences have been seen primarily in extinction rates; but unlike our study, males have been reported to extinguish more slowly than females (8,10,17,50,64,66,67). A specific role for sex steroids in the modulation of extinction rates has been demonstrated in a few studies, but no study has examined cyclic variation across the estrous cycle.…”

Section: Discussioncontrasting

confidence: 59%

“…Alternatively, the results from the present study could be specific to MFinduced CTA or due to differences in testing parameters [e.g., one-bottle vs. two-bottle tests (50,66,67) or sucrose vs. saccharin (9,57).] It may be relevant that we matched saccharin intakes between male and female groups by excluding rats with the highest and lowest intakes during conditioning.…”

Section: Discussionmentioning

confidence: 99%

“…Gonadectomy in male rats has no effect, but in female rats, it decreases locomotion and rearing (61,62). Sex differences have also been reported in lithium chloride-induced CTA, particularly in that males require a longer time to extinguish CTA (8,10,50,64,66,67). Sex differences might exist in MF responses that might be of clinical significance, particularly if high-strength MFs interact with the vestibular system.…”

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confidence: 99%

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Sex and estrous cycle differences in the behavioral effects of high-strength static magnetic fields: role of ovarian steroids

Cason¹,

DenBleyker²,

Ferrence³

et al. 2006

American Journal of Physiology-Regulatory, Integrative and Comp

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Advances in magnetic resonance imaging are driving the development of higher-resolution machines equipped with high-strength static magnetic fields (MFs). The behavioral effects of high-strength MFs are largely uncharacterized, although in male rats, exposure to 7 T or above induces locomotor circling and leads to a conditioned taste avoidance (CTA) if paired with a novel taste. Here, the effects of MFs on male and female rats were compared to determine whether there are sex differences in behavioral responses and whether these can be explained by ovarian steroid status. Rats were given 10-min access to a novel saccharin solution and then restrained within a 14-T magnet for 30 min. Locomotor activity after exposure was scored for circling and rearing. CTA extinction was measured with two-bottle preference tests. In experiment 1, males were compared with females across the estrous cycle after a single MF exposure. Females circled more and acquired a more persistent CTA than males; circling was highest on the day of estrus. In experiment 2, the effects of three MF exposures were compared among intact rats, ovariectomized females, and ovariectomized females with steroid replacement. Compared with intact rats, ovariectomy increased circling; estrogen replacement blocked the increase. Males acquired a stronger initial CTA but extinguished faster than intact or ovariectomized females. Thus the locomotor circling induced by MF exposure was increased in females and modulated by ovarian steroids across the estrous cycle and by hormone replacement. Furthermore, female rats acquired a more persistent CTA than male rats, which was not dependent on estrous phase or endogenous ovarian steroids.

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Section: Discussioncontrasting

confidence: 59%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Sex and estrous cycle differences in the behavioral effects of high-strength static magnetic fields: role of ovarian steroids

Cason¹,

DenBleyker²,

Ferrence³

et al. 2006

American Journal of Physiology-Regulatory, Integrative and Comp

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“…Finally, another commonly used model is based on the conditioned preference or avoidance of a place that has been associated with an addictive substance (Randall-Thompson and Riley, 2003;Busse et al, 2005;Jones et al, 2006;Rinker et al, 2008). In the conditioned place preference paradigm, with the use of cocaine, female rats exhibit place preference in fewer trials than male rats (Russo et al, 2003a,b).…”

Section: Sex Differences In Animal Models Of Substance-related Disordersmentioning

confidence: 99%

“…However, it has been found that the response rate is highest during oestrus and this is not due to enhanced activity levels (Prescott, 1966). Also, peak ICSS response with stimulation of the pars compacta of the substantia nigra has been observed in the night of prooestrous to oestrus (Steiner et al, 1981).Finally, another commonly used model is based on the conditioned preference or avoidance of a place that has been associated with an addictive substance (Randall-Thompson and Riley, 2003;Busse et al, 2005;Jones et al, 2006;Rinker et al, 2008). In the conditioned place preference paradigm, with the use of cocaine, female rats exhibit place preference in fewer trials than male rats (Russo et al, 2003a,b).…”

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confidence: 99%

Sex differences in animal models of psychiatric disorders

Kokras

Dalla

2014

British J Pharmacology

359

187

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Psychiatric disorders are characterized by sex differences in their prevalence, symptomatology and treatment response. Animal models have been widely employed for the investigation of the neurobiology of such disorders and the discovery of new treatments. However, mostly male animals have been used in preclinical pharmacological studies. In this review, we highlight the need for the inclusion of both male and female animals in experimental studies aiming at gender-oriented prevention, diagnosis and treatment of psychiatric disorders. We present behavioural findings on sex differences from animal models of depression, anxiety, post-traumatic stress disorder, substance-related disorders, obsessive-compulsive disorder, schizophrenia, bipolar disorder and autism. Moreover, when available, we include studies conducted across different stages of the oestrous cycle. By inspection of the relevant literature, it is obvious that robust sex differences exist in models of all psychiatric disorders. However, many times results are conflicting, and no clear conclusion regarding the direction of sex differences and the effect of the oestrous cycle is drawn. Moreover, there is a lack of considerable amount of studies using psychiatric drugs in both male and female animals, in order to evaluate the differential response between the two sexes. Notably, while in most cases animal models successfully mimic drug response in both sexes, test parameters and treatment-sensitive behavioural indices are not always the same for male and female rodents. Thus, there is an increasing need to validate animal models for both sexes and use standard procedures across different laboratories. LINKED ARTICLESThis article is part of a themed section on Animal Models in Psychiatry Research. To view the other articles in this section visit http://dx.doi.org/10. 1111/bph.2014.171.issue-20 Abbreviations 5-HTT, 5-HT transporter; 8-OH-DPAT, 7-(Dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-ol; Akt1, V-akt murine thymoma viral oncogene homologue 1; BDNF, brain-derived neurotrophic factor; BTBR, BTBR T + tf/J; CMS, chronic mild stress; COMT, catechol-O-methyltransferase-deficient mice; CR, conditioned response; CRF, corticotrophinreleasing factor; CS, conditioned stimulus; D1 receptor, dopamine 1 receptor; D2 receptor, dopamine 2 receptor; DISC1, disrupted-in-schizophrenia 1; Ehmt1, euchromatin histone methyltransferase 1; FBGRKO, forebrain glucocorticoid type II receptor (NR3C1) knockout; FSL, flinders sensitive rat line; FST, forced swim test; GSK3, glycogen synthase kinase 3; HAB, high anxiety-related behaviour rats; ICSS, intracranial self-stimulation; LAB, low anxiety-related behaviour rats; LI, latent inhibition; Mthfr, methylenetetrahydrofolate reductase; OCD, obsessive-compulsive disorder; PPI, prepulse inhibition; PTSD, post-traumatic stress disorder; SSRI, selective 5-HT re-uptake inhibitors; US, unconditioned stimulus; WKY, Wistar Kyoto IntroductionThe total disease burden for neuropsychiatric disorders in the European Union has been recently ...

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Conditioned Flavor Aversions: Assessment of Drug‐Induced Suppression of Food Intake

Riley

Freeman

2004

CP Neuroscience

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Administration of a drug following ingestion of a novel food or solution often suppresses subsequent intake of the new food or solution. This suppression is associative, in that consumption is not suppressed when there is no temporal relationship between consumption and drug administration. The robust nature of aversion learning has made this procedure a sensitive and widely used behavioral index of drug side effects. The procedures described in this unit are suitable for work with rodents, and may require modifications, e.g., in presentation of the ingesta and drug for other species. Familiar and novel foods may be used instead of solutions, with similar results.

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Morphine-induced conditioned taste aversions: assessment of sexual dimorphism

Cited by 38 publications

References 61 publications

Sex and estrous cycle differences in the behavioral effects of high-strength static magnetic fields: role of ovarian steroids

Sex and estrous cycle differences in the behavioral effects of high-strength static magnetic fields: role of ovarian steroids

Sex differences in animal models of psychiatric disorders

Conditioned Flavor Aversions: Assessment of Drug‐Induced Suppression of Food Intake

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