Morphine-induced place preference: Involvement of the central amygdala NMDA receptors

Rezayof, Ameneh; Golhasani-Keshtan, Farideh; Haeri-Rohani, Ali; Zarrindast, Mohammad‐Reza

doi:10.1016/j.brainres.2006.11.049

Cited by 44 publications

(31 citation statements)

References 64 publications

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“…Nearly all postpartum females (83%) expressed robust chamber preference for 5 mg/kg IP cocaine, but only approximately half of the postpartum females preferred the cocaine-associated chamber associated with higher doses (10-20 mg/kg) and the lowest (0.5 mg/kg) dose tested. Although CPP has been considered to be relatively insensitive to dose manipulations (Bevins 2005;Bevins and Cunningham 2006), the present study supports previous reports of consistent relationships between varied drug doses and CPP or CPP effect size (Bardo et al 1995;Roma et al 2006;Davis et al 2007;Rezayof et al 2007). …”

Section: Discussionsupporting

confidence: 89%

Incentive salience of cocaine across the postpartum period of the female rat

et al. 2008

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Rationale-Objectives-Our prior conditioned place preference (CPP) work demonstrates that late (day16) postpartum female rats consistently prefer cocaine-over pup-associated chambers, whereas far fewer early postpartum (day8) females prefer the cocaine-associated chamber. The present study examines early and late postpartum females' preference for a cocaine-associated chamber when contrasted with a chamber associated with saline (rather than pups).Materials and methods-Postpartum females were tested for conditioned preference for chambers associated with cocaine (10 mg/kg subcutaneous (SC) or 0.5, 5, 10, or 20 mg/kg intraperitoneal (IP) injections) versus saline; preferences of virgin female and male rats for select cocaine stimuli (10mg/kg SC or IP) were also tested. Locomotion was recorded during CPP conditioning and testing.Results-Early and late postpartum females expressed strikingly similar preference for the cocaineassociated chamber across all administration routes and doses. IP cocaine produced an orderly, inverted U-shaped dose-preference curve, with preference peaking at the 5 mg/kg dose (83% of females). While many postpartum females preferred 10mg/kg cocaine administered either SC or IP, both virgin females and males expressed strong aversion to SC cocaine and, while virgin females strongly preferred IP cocaine, males remained relatively indifferent. Across 10mg/kg IP cocaineconditioning sessions, locomotor sensitization occurred exclusively in cocaine-but not salinepreferring postpartum females. Locomotor rate was lower in preferred versus nonpreferred chambers at CPP test.Conclusions-Early and late postpartum females may be equally and uniquely susceptible to sampling and/or abuse of modestly salient doses of cocaine (10mg/kg SC; 5mg/kg IP) compared to virgin females and/or males.

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Section: Discussionsupporting

confidence: 89%

Incentive salience of cocaine across the postpartum period of the female rat

et al. 2008

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“…These effects are mediated by NMDAR populations in multiple brain regions. Consistent with this, NMDAR antagonism in the central amygdala or the nucleus accumbens core attenuates the expression of morphine-conditioned place preference (Rezayof et al, 2007) and explicit cue-induced instrumental cocaine-seeking behavior (Backstrom and Hyytia, 2007), respectively. NMDAR antagonism in the DH also disrupts the expression of amphetamine-induced conditioned place preference (Sakurai et al, 2007); however, it has yet to be investigated whether the stimulation of NMDAR populations in the DH is necessary for drug context-induced reinstatement of instrumental drug-seeking behavior.…”

Section: Introductionsupporting

confidence: 58%

Role of a Hippocampal Src-Family Kinase-Mediated Glutamatergic Mechanism in Drug Context-Induced Cocaine Seeking

Xie

Arguello

Wells

et al. 2013

Neuropsychopharmacol

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Glutamatergic neurotransmission in the dorsal hippocampus (DH) is necessary for drug context-induced reinstatement of cocaineseeking behavior in an animal model of drug relapse. Furthermore, in vitro studies suggest that the Src family of tyrosine kinases critically regulates glutamatergic cellular functions within the DH. Thus, Src-family kinases in the DH may similarly control contextual cocaineseeking behavior. To test this hypothesis, rats were trained to lever press for un-signaled cocaine infusions in a distinct context followed by extinction training in a different context. Cocaine-seeking behavior (non-reinforced active lever pressing) was then assessed in the previously cocaine-paired and extinction contexts after AP5 (N-methyl-D-aspartate glutamate (NMDA) receptor (NMDAR) antagonist; 0.25 or 2.5 mg/0.5 ml/hemisphere), PP2 (Src-family kinase inhibitor; 6.25 or 62.5 ng/0.5 ml/hemisphere), Ro25-6981 (NR2B subunitcontaining NMDAR antagonist; 0.2 or 2 mg/0.5 ml/hemisphere), or vehicle administration into the DH. Administration of AP5, PP2, or Ro25-6981 into the DH dose-dependently impaired drug context-induced reinstatement of cocaine-seeking behavior relative to vehicle, without altering instrumental behavior in the extinction context or food-reinforced instrumental responding and general motor activity in control experiments. Cocaine-seeking behavior during the first 20 min of the test session in the cocaine-paired context was associated with an increase in NR2B subunit activation, and intra-DH PP2 pretreatment disrupted this relationship. Together, these findings suggest that Src-family kinase activation, NMDAR stimulation, and likely Src-family kinase-mediated NR2B subunit-containing NMDAR activation in the DH are necessary for incentive motivational and/or memory processes that promote contextual cocaine-seeking behavior.

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“…Preclinical behavioral pharmacological and neuropharmacological studies indicate that coadministration of NMDA receptor antagonists with morphine attenuate the development or expression of dependence in rodents (Noda and Nabeshima, 2004;Rezayof et al, 2007). A major central mediator of excitatory signaling by the amino acid neurotransmitter glutamate, the NMDA receptor is a heteromer of the essential NMDA-R1 (NR1) subunit and some combination of NMDA-NR2 subunits (Wenthold et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Conditional deletion of the NMDA-NR1 receptor subunit gene in the central nucleus of the amygdala inhibits naloxone-induced conditioned place aversion in morphine-dependent mice

Glass

Hegarty²,

Oselkin

et al. 2008

Experimental Neurology

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Preclinical behavioral pharmacological and neuropharmacological evidence indicates that the NMDA receptor plays an important role in opioid dependence, however, the neural substrates subserving these actions are poorly understood. The central nucleus of the amygdala (CeA) is a critical coordinator of autonomic, behavioral, and emotional systems impacted by opioids, however there is no evidence that the essential NMDA-NR1 (NR1) subunit gene in the amygdala plays a role in opioid dependence. To determine the role of the NR1 subunit gene in the amygdala with respect to physical and psychological opioid withdrawal, a spatial-temporal deletion of this gene was produced by microinjecting a recombinant adeno-associated virus (rAAV) expressing the GFP reporter and Cre recombinase (rAAV-GFP-Cre) into the CeA of adult "floxed" NR1 mice (fNR1). Amygdala microinjection of rAAV-GFP-Cre produced a decrease in NR1 gene expression and protein immunolabeling in postsynaptic sites of neurons without signs of compromised ultrastructural neuronal morphology. Amygdala NR1 gene deletion also did not affect locomotor, somatosensory, or sensory-motor behaviors. In addition, bilateral local NR1 gene deletion did not impact somatic or visceral withdrawal symptoms precipitated by naloxone in morphine-dependent mice. However, there was a significant deficit in the expression of an opioid withdrawal-induced conditioned place aversion in mice with amygdala NR1 deletion. These results indicate that functional amygdala NMDA receptors are involved in aversive psychological Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access

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Morphine-induced place preference: Involvement of the central amygdala NMDA receptors

Cited by 44 publications

References 64 publications

Incentive salience of cocaine across the postpartum period of the female rat

Incentive salience of cocaine across the postpartum period of the female rat

Role of a Hippocampal Src-Family Kinase-Mediated Glutamatergic Mechanism in Drug Context-Induced Cocaine Seeking

Conditional deletion of the NMDA-NR1 receptor subunit gene in the central nucleus of the amygdala inhibits naloxone-induced conditioned place aversion in morphine-dependent mice

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