Morphine Radioimmunoassay Specificity Before and After Extraction of Plasma and Cerebrospinal Fluid

Grabinski, Patricia Y.; Kaiko, Robert F.; Walsh, Declan; Foley, Kathleen M.; Houde, Raymond W.

doi:10.1002/jps.2600720107

Cited by 31 publications

(3 citation statements)

References 17 publications

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“…1984) was tried which was reported to be equally as reliable, but resulted in plasma morphine concentrations an order of magnitude higher than the former assay. This discrepancy in the magnitude of plasma morphine concentrations is a phenomenon previously reported (Catlin 1977;Grabinski et a!. 1983).…”

Section: Methodsmentioning

confidence: 69%

Steady-State Pharmacokinetics of Controlled Release Oral Morphine Sulphate in Healthy Subjects

Savarese¹,

Goldenheim²,

Thomas³

et al. 1986

Clinical Pharmacokinetics

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The pharmacokinetics of oral morphine sulphate as controlled release tablets ('MS-Contin') and solution were compared at steady-state. Plasma morphine concentrations were determined over 24 hours following the last dose of each drug when given in a randomised, crossover fashion to healthy subjects. Radioimmunoassay was used, which was sensitive yet provided good specificity relative to high-performance liquid chromatography. Controlled release tablets had 86% the bioavailability of the solution. Although each dose of controlled release tablets was double that of the solution, their peak plasma concentrations were the same. Time to maximum concentration was 3 times longer for controlled release tablets with an absorption half-life twice that of the solution. Elimination of both drugs was similar and biphasic with the minor terminal portion at 10 times the half-life of the major early process. These data explain the analgesic duration of 12 hours observed in clinical studies and the lack of accumulation with morphine compared with methadone.

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Section: Methodsmentioning

confidence: 69%

Steady-State Pharmacokinetics of Controlled Release Oral Morphine Sulphate in Healthy Subjects

Savarese¹,

Goldenheim²,

Thomas³

et al. 1986

Clinical Pharmacokinetics

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“…Immunoassay methods do not rely on separation but require that co-extractants do not cross-react; the more of these present, and the less well-defined they are, the more difficult this is to establish. Our results suggest that immunoassay determinations of morphine in serum should be viewed with caution, especially in renal failure patients where the retention of water-soluble metabolites that are potentially immunologically cross-reactive is an additional concern (Joel et al, 1985;Grabiuski et al, 1983).…”

Section: Methodsmentioning

confidence: 92%

Renal failure does not impair the metabolism of morphine.

Woolner¹,

Winter²,

Frendin³

et al. 1986

Brit J Clinical Pharma

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1 The pharmacokinetics of morphine were measured using gas chromatography-mass spectrometry (GCMS) with specific ion monitoring after the intramuscular administration of papaveretum to four patients with renal failure (one anephric) and three normals.2 The apparent tl/2 of absorption and t/2 of elimination were significantly shorter in the patients with renal failure (P < 0.05). 3 Morphine glucuronides are eliminated slowly in these patients as expected. 4 Renal failure does not impair the elimination of morphine.

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“…ABG results were not corrected for body temperature because it was not usual hospice practice to check body temperature. The plasma morphine assay utilized an extraction procedure to remove polar metabolites of morphine [6,13,14].…”

Section: Methodsmentioning

confidence: 99%

Oral morphine and respiratory function amongst hospice inpatients with advanced cancer

Walsh

Rivera

Kaiko

2003

Supportive Care in Cancer

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The Prognostic Inflammatory Nutritional Index (PINI) is a simple scoring system that has been used to evaluate nutritional status and prognosis in critically ill patients. The PINI has never been evaluated in advanced cancer. Fifty consecutive patients with advanced cancer, weight loss, and anorexia were studied. C-reactive protein (CRP), albumin, pre-albumin, interleukin-6 (IL-6), and alpha 1-acid glycoprotein (AAG) were evaluated. The individual values for AAG, CRP, and IL-6 were markedly elevated. In contrast to albumin and prealbumin, CRP levels were very high. The PINI was significantly elevated, and higher than reported in critically ill intensive care patients. Elevated IL-6 levels correlated with high PINI and CRP values. CRP, IL-6, and PINI should be considered in future research on nutritional status and prediction of prognosis in advanced cancer.

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Morphine Radioimmunoassay Specificity Before and After Extraction of Plasma and Cerebrospinal Fluid

Cited by 31 publications

References 17 publications

Steady-State Pharmacokinetics of Controlled Release Oral Morphine Sulphate in Healthy Subjects

Steady-State Pharmacokinetics of Controlled Release Oral Morphine Sulphate in Healthy Subjects

Renal failure does not impair the metabolism of morphine.

Oral morphine and respiratory function amongst hospice inpatients with advanced cancer

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