2010
DOI: 10.1124/mol.110.066837
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Morphine Regulates Dopaminergic Neuron Differentiation via miR-133b

Abstract: Morphine is one of the analgesics used most to treat chronic pain, although its long-term administration produces tolerance and dependence through neuronal plasticity. The ability of morphine to regulate neuron differentiation in vivo has been reported. However, the detailed mechanisms have not yet been elucidated because of the inability to separate maternal influences from embryonic events. Using zebrafish embryos as the model, we demonstrate that morphine decreases miR-133b expression, hence increasing the … Show more

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Cited by 101 publications
(89 citation statements)
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“…In this study, the knockdown of ZfDOR2 and ZfMOR regulated the expression of tacr1a and tacr1b respectively, indicating that tachykinin and the opioid systems are closely interrelated in zebrafish, as has been described in mammals (Minami et al 1995, Pfeiffer et al 2003, Guan et al 2005, Yu et al 2009). As the set of MOs of opioid receptors was effective, as previously demonstrated by Sanchez-Simon et al (2010), and replicated in our study, we are convinced that the changes on the expression of the TACRs are a consequence of the downregulation of the opioid receptors. As we are studying the changes of gene expression in vivo whole-mount zebrafish embryos, it is difficult to know whether the effects that we observe are specifically produced by opioid receptors as other genes or elements can also regulate both the opioid and the tachykinin system.…”
Section: Discussionsupporting
confidence: 88%
“…In this study, the knockdown of ZfDOR2 and ZfMOR regulated the expression of tacr1a and tacr1b respectively, indicating that tachykinin and the opioid systems are closely interrelated in zebrafish, as has been described in mammals (Minami et al 1995, Pfeiffer et al 2003, Guan et al 2005, Yu et al 2009). As the set of MOs of opioid receptors was effective, as previously demonstrated by Sanchez-Simon et al (2010), and replicated in our study, we are convinced that the changes on the expression of the TACRs are a consequence of the downregulation of the opioid receptors. As we are studying the changes of gene expression in vivo whole-mount zebrafish embryos, it is difficult to know whether the effects that we observe are specifically produced by opioid receptors as other genes or elements can also regulate both the opioid and the tachykinin system.…”
Section: Discussionsupporting
confidence: 88%
“…Increasing evidence suggests that morphine treatment can modulate the expression of various miRNAs (Wu et al 2009;Dave and Khalili 2010;Sanchez-Simon et al 2010). Since morphine down regulates the expression of anti-HIV miRNAs in monocytes in vitro and heroin addicts have lower levels of these miRNAs in PBMCs (Wang et al 2011), and down-regulation of these miRNAs can promote replication of latent HIV-1 in resting CD4+ T cells (Huang et al 2007) and in monocytes (Wang et al 2009) …”
Section: Discussionmentioning
confidence: 99%
“…Mu opioids such as morphine modulate expression of a number of miRNAs (Sanchez-Simon et al, 2010;Zheng et al, 2010;Wu et al, 2008Wu et al, , 2013Dave and Khalili, 2010;He et al, 2010;Wang et al, 2011), and several miRNAs regulate MOR-1 expression (Wu et al, 2008(Wu et al, , 2009He et al, 2010). Dysregulation of miRNAs has been linked to morphine tolerance and addiction Dreyer, 2010;Hwang et al, 2012;Tapocik et al, 2013).…”
Section: Introductionmentioning
confidence: 99%