Morphine selectively influences macronutrient intake in the rat

Marks-Kaufman, Robin; Kanarek, Robin B.

doi:10.1016/0091-3057(80)90048-9

Cited by 112 publications

(41 citation statements)

References 12 publications

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“…This anorexia differs from previous reports of morphine induced anorexia (Frenk and Rogers 1979;Marks-Kaufman and Kanarek 1980;Sanger and McCarthy 1980;Cooper 1981) in that it is delayed, and since it occurred both after deprivation and after rats had been feeding for 4 h, it does not seem to be deprivation dependent (Sanger and McCarthy 1980). Moreover, this anorexia does not contradict opiate promotion of appetite (Grandison and Guidotti 1977;Jalowiec et al 1981;Cooper and Sanger 1984;Gold and Sternbach 1984;Morley et al 1984) which precedes it, and which was also demonstrated in this experimental design.…”

Section: Discussioncontrasting

confidence: 55%

“…A large body of evidence attesting to the opiates' hyperphagic influence (Grandison and Guidotti 1977;Cooper and Sanger 1984;Gold and Sternbach 1984;Morley et al 1984) has served to draw attention away from the earlier reports of morphine-induced anorexia (Frenk and Rogers 1979;Marks-Kaufman and Kanarek 1980;Sanger and McCarthy 1980;Cooper 1981;Leshem 1981a;Kunihara et al 1983). There are good reasons for this bias in favour of opiate-induced hyperphagia.…”

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confidence: 99%

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Morphine induces delayed anorexia in rats

Leshem

1988

Psychopharmacology

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The delayed suppression of feeding caused by morphine was investigated in the rat. A single injection of morphine evoked a triphasic influence on feeding: a brief (1 h) severe anorexia was followed by hyperphagia (3 h) and a mild (20%) yet persistent (4-24 h) anorexia. This latter anorexic effect was at least partially naltrexone reversible, and the duration of this antagonism (8 h) was longer than that of naltrexone's anorexic effect (4 h). Delayed morphine anorexia cannot be ascribed to morphine's initial stuporific influence, and it was not dependent upon previous feeding or deprivation. It was not due to gastric distension. The specificity and significance of this anorexia is discussed.

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Section: Discussioncontrasting

confidence: 55%

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confidence: 99%

Morphine induces delayed anorexia in rats

Leshem

1988

Psychopharmacology

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“…Such patterns are affected by physiological and environmental variables such as pregnancy (7,8), lactation (8), exposure to cold (9), responses to various drugs (10)(11)(12)(13), and neuronal damage (14)(15)(16).…”

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confidence: 99%

Relation of body energetic status to dietary self-selection in Sprague-Dawley rats.

Matsuo

Shimakawa

Ikeda

et al. 1984

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…In the early 1980s investigators made the observation that after the injection of a non-selective opioid agonist (i.e. morphine) animals increased their fat intake while suppressing carbohydrate intake and exhibiting little modification in protein intake (Marks-Kaufman 1982, Marks-Kaufman andKanarek 1980). Later studies by suggested that endogenous opioids within the ventral striatum participate in the mechanisms governing preferences for highly palatable foods, especially those rich in fat.…”

Section: Introductionmentioning

confidence: 99%