2022
DOI: 10.1002/prp2.1016
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Morphine stimulates cervical cancer cells and alleviates cytotoxicity of chemotherapeutic drugs via opioid receptor‐dependent and ‐independent mechanisms

Abstract: Morphine is frequently applied in cancer patients for pain management. However, its effects on cancer are not well understood but observed to be specific to certain cancer types. We previously revealed the stimulatory properties of morphine in esophageal carcinoma. This work addressed the effects of morphine and its underlying mechanisms in cervical cancer. Proliferation, apoptosis, and migration assays were performed to examine the effects of morphine alone and its combinatory effects with chemotherapeutic dr… Show more

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Cited by 6 publications
(3 citation statements)
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“…Another study 14 reported that 1 or 10 μM morphine treatment reduced the apoptotic effects of doxorubicin or paclitaxel by decreasing the cleavage of PARP and caspase. In a recent study by Yu et al 25 , it has been shown that the apoptotic effects of common chemotherapeutic drugs, paclitaxel, cisplatin, and 5-FU, on cervical cancer cells are significantly reduced by morphine. On the contrary, some studies have shown that morphine has cytotoxic effects on various human cancer cell lines 10 , 11 .…”
Section: Discussionmentioning
confidence: 99%
“…Another study 14 reported that 1 or 10 μM morphine treatment reduced the apoptotic effects of doxorubicin or paclitaxel by decreasing the cleavage of PARP and caspase. In a recent study by Yu et al 25 , it has been shown that the apoptotic effects of common chemotherapeutic drugs, paclitaxel, cisplatin, and 5-FU, on cervical cancer cells are significantly reduced by morphine. On the contrary, some studies have shown that morphine has cytotoxic effects on various human cancer cell lines 10 , 11 .…”
Section: Discussionmentioning
confidence: 99%
“…For instance, in cervical cancer cells, morphine has been shown to increase cell proliferation and cell migration. 18 Additionally, morphine and oxycodone increase endothelial cell tube formation and proliferation in a dose-dependent manner. 19 …”
Section: Opioidsmentioning
confidence: 99%
“…For instance, in cervical cancer cells, morphine has been shown to increase cell proliferation and cell migration. 18 Additionally, morphine and oxycodone increase endothelial cell tube formation and proliferation in a dose-dependent manner. 19 When analysing the association between opioid administration during cancer surgery and cancer progression, the data is conflicting.…”
Section: Opioidsmentioning
confidence: 99%