Morpho-Functional State of the Small Intestine With the Syndrome Enteral Insufficiency in Experi-Mental Peritonitis and Antioxidant Therapy

Волков, Д. В.; Стадников, А. А.; Тарасенко, В. С.; Чукина, О. В.; Kornilov, Sergey A.

doi:10.17513/spno.24316

Cited by 2 publications

(2 citation statements)

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“…The intestine is one of the most important organs to primarily experience pathological changes. Mild and severe ischemia cases are distinguished based on the nature of the morphological changes in the intestinal wall, with the necrosis of individual enterocytes in the area of the small intestine’s villi being a hallmark of severe disease [ 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Morphofunctional Alteration of Mesenteric Lymph Nodes in the Inflammation of the Abdominal Cavity

Abdreshov,

Demchenko,

Yeshmukhanbet

et al. 2024

Biology

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This paper provides data regarding the ratios of the functional structures of lymph nodes after inflammation in the abdominal organs. Lymph systems, including lymph nodes, function as filters of tissues and tissue fluids and are places of origin and lymphocyte production for normal physiological functions. They display specific morphological and functional responses in reaction to endogenous and exogenous substances. The morphological pattern of the mesenteric lymph node in experimental rat groups reflects a decrease in its immune function due to the processes of inflammation in the abdominal cavity. These processes work together with the associated organs and their involvement in the abdominal lymph nodes, in which there are discharges of the structure of the paracortical zone under conditions of reduced lymphogenic processes, according to the decrease in the size of the paracortex and the ratios of lymphoid nodes with and without germinal centers. Histological and morphometric analyses show changes in the mesenteric lymph node. These analyses are characterized by changes in the cortical and medullary substances, while the proportion of the cortical structure decreases. We also noted an increase in the number of macrophages in the lymphoid nodes and cerebral sinus, as well as a decrease in the number of mature plasmocytes, the paracortex, and the pulp strands. These changes indicate immunosuppressive effects on the lymph node. Under the conditions of inflammation, the formation of a mixed immune response occurs.

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Section: Introductionmentioning

confidence: 99%

Morphofunctional Alteration of Mesenteric Lymph Nodes in the Inflammation of the Abdominal Cavity

Abdreshov,

Demchenko,

Yeshmukhanbet

et al. 2024

Biology

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“…In the pathogenesis of its damage during inflammation, ischemia is of great importance. According to the nature of morphological changes in the intestinal wall, mild and severe degrees of ischemia are distinguished, in particular, it is characterized by necrosis of individual enterocytes in the region of the tip of the villi of the small intestine [16,17].…”

Section: Introductionmentioning

confidence: 99%

Morphofunctional and morphometric features of the small intestine in experimental rats with inflammation of the abdominal cavity

Abdreshov,

Yessenova,

Yeshmukhanbet

et al. 2024

IJBCh

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The article presents studies of the effect of fecal suspension by introducing into the abdominal cavity at the rate of 0.5 ml of a 10% solution per 100 g of animal body weight. The morpho-functional state and morphometric analyzes of the small intestine were studied in normal conditions and with inflammation of the abdominal organs by introducing fecal suspension. The results showed that inflammation of the abdominal organs led to significant changes in the wall of the small intestine, multiple hemorrhages and fibrin clots were found. In the intestine, there is a change and violation of the structures of the small intestine, the total thickness of the mucous membrane increases. Violation of goblet cells, villus height and crypt depth occur. Analysis of the study showed that the walls of the small intestine, revealed structural changes, mainly in the mucosa, submucosa and muscle membranes. The mean value of the mucosal thickness in the control group was 526.17±17.11 micrometer; submucous layer – 47.21±1.63 micrometer. Phenomena of edema, inflammatory infiltration, and separation of muscle fibers were noted in both layers of the muscular membrane. The average layer of thickness of the muscular membrane was 145.67±6.92 µm. Changes in the mucous membrane of the small intestine, at one time reflected in the structural changes in the villi-crypt of the small intestine. A violation of microcirculation in the tissues of the small intestine after the inflammatory process was revealed, which leads to aggravation of dystrophic and necrobiotic lesions of the overall state of the small intestine and is combined with the severity of the clinical picture in experimental animals.

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Morpho-Functional State of the Small Intestine With the Syndrome Enteral Insufficiency in Experi-Mental Peritonitis and Antioxidant Therapy

Cited by 2 publications

References 1 publication

Morphofunctional Alteration of Mesenteric Lymph Nodes in the Inflammation of the Abdominal Cavity

Morphofunctional Alteration of Mesenteric Lymph Nodes in the Inflammation of the Abdominal Cavity

Morphofunctional and morphometric features of the small intestine in experimental rats with inflammation of the abdominal cavity

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