Morphoea: a manifestation of infection with Borrelia species?

Eisendle, Klaus; Grabner, Tanja; Zelger, Bernhard

doi:10.1111/j.1365-2133.2007.08235.x

Cited by 67 publications

(52 citation statements)

References 58 publications

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“…Second, the involvement was severe leading to significant gingival recession, bone resorption and external tooth resorption. Third, no potential triggering factor, such as trauma, radiation or B. burgdorferi infection [29] was identified. Multiple drugs have been implicated in the development of morphea-like lesions [30].…”

Section: Discussionmentioning

confidence: 99%

Oral Mucosal Morphea: A New Variant

et al. 2012

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Morphea is a cutaneous disorder characterized by an excessive collagen deposition. While in almost all cases the sclerosing process exclusively affects the skin, there are anecdotal cases in which associated mucosal involvement has been described. We here report the case of a woman developing a whitish indurated plaque over the left upper vestibular mucosa and hard palate leading to dental mobility and exposure of the roots of several teeth. Cone beam computed tomography of the left maxilla showed bone resorption involving the upper cuspid to the second molar region with widened periodontal ligament spaces, while light microscopy studies demonstrated epithelial atrophy and fibrosis of the dermis extending into the submucosa with hyalinization of subepithelial collagen. Our observation expands the spectrum of clinical presentations of morphea and provides the first example of isolated oral morphea. Its recognition is important to avoid significant local complications.

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Section: Discussionmentioning

confidence: 99%

Oral Mucosal Morphea: A New Variant

et al. 2012

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“…Infections such as those with Epstein-Barr virus, varicella, morbilli, or borreliosis, have been reported as underlying factors for the onset of morphea and furthermore they have been recommended as a possible trigger factors for morphea. Borrelia burgdorferi today is a possible etiologic factor [6]. Antibodies to B. burgdorferi and high antinuclear antibody titers have been described in patients with morphea, and it has been suggested that Borrelia-associated early-onset morphea may represent a subset of patients with infection-induced autoimmunity.…”

Section: Resultsmentioning

confidence: 99%

Localised Scleroderma-Patchy Type Morphea

Blyta¹

2013

J Clin Exp Dermatol Res

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“…The studies with negative PCR results were more rigorous in that they investigated larger numbers of patients and applied more than one primer set. In other reports the association has been alleged based on diagnostic methods that are far less specific such as immunohistology, focus-floating microscopy, silver staining, or lymphoproliferative response assays (Buechner et al, 1995;Eisendle et al, 2007). In case reports, B. burgdorferi infection has been implicated in the causation of two additional sclerosing disorders, progressive facial hemiatrophy and eosinophilic fasciitis (Shulman syndrome), based on silver staining, immunohistology, or PCR (Stern et al, 1992;Granter et al, 1994).…”

Section: Borrelia Burgdorferi and Sclerosing Skin Conditionsmentioning

confidence: 99%