2015
DOI: 10.1007/s10517-015-2869-x
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Morphofunctional Adaptation of Rat Thymus Structures to Silicon Consumption with Drinking Water

Abstract: Administration of standardized drinking water containing 10 mg/liter silicon for 2 months adlibitum induced structural reorganization of the cortical and medullary layers of the thymiclobules in laboratory rats accompanied by functional activation of monocyte/macrophage cells and antigen-presenting cells was changed in morphological structures of the thymus. A possible mechanism of development of autoimmune processes under the effect of silicon is discussed.

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Cited by 5 publications
(2 citation statements)
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“…The obtained results of the study may indicate a more pronounced positive dose-dependent effect of silicate citrate on nonspecific factors of body protection and phagocytic activity of rabbit blood, confirming previously obtained data on the immunophysiological reactivity of their organism (Ivanytska et al, 2017). It should be noted that all changes in white blood cell parameters were within the limits of physiological parameters, which may indicate the stimulatory effect of the silicon organic compound on the main populations of leukocytes and hemopoiesis (Gordova et al, 2015). The presentation of different amounts of silicon compounds did not reveal significant differences between the control and experimental groups of animals.…”
Section: Discussionsupporting
confidence: 88%
“…The obtained results of the study may indicate a more pronounced positive dose-dependent effect of silicate citrate on nonspecific factors of body protection and phagocytic activity of rabbit blood, confirming previously obtained data on the immunophysiological reactivity of their organism (Ivanytska et al, 2017). It should be noted that all changes in white blood cell parameters were within the limits of physiological parameters, which may indicate the stimulatory effect of the silicon organic compound on the main populations of leukocytes and hemopoiesis (Gordova et al, 2015). The presentation of different amounts of silicon compounds did not reveal significant differences between the control and experimental groups of animals.…”
Section: Discussionsupporting
confidence: 88%
“…Відомо, що до показників гуморальної ланки природних механізмів захисту організму кролів належать бактерицидна і лізоцимна активність сироватки крові [4,6]. Проведені дослідження показали (табл.…”
Section: результати й обговоренняunclassified