Morphofunctional State and Circadian Rhythms of the Liver under the Influence of Chronic Alcohol Intoxication and Constant Lighting

Kozlova, Maria; Kirillov, Yuri; Makartseva, Lyudmila; Чернов, И. А.; Areshidze, David А.

doi:10.3390/ijms222313007

Cited by 8 publications

(2 citation statements)

References 72 publications

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“…Несомненно, стресс, вызванный непрерывным освещением, вносит свой вклад в развитие наблюдаемой в гепатоцитах животных 2-й и 6-й групп мелкокапельной жировой дистрофии. Доказано, что прогрессирование дистрофических изменений в гепатоцитах напрямую коррелирует с продолжительностью стрессорного воздействия, что обусловлено ростом концентрации глюкокортикоидов, вызывающих усиление экспрессии серотониновых рецепторов 5-HT2A и 5-НТ2B, триптофангидроксилазы 1 и синтеза серотонина, а накопление гепатоцитами липидных капель при стрессе протекает на фоне усиления экспрессии некоторых генов липолиза и β-окисления жирных кислот [21,27].…”

Section: Discussionunclassified

“…Большая часть исследований посвящена раздельному и совместному влиянию ХАИ и темновой депривации на структуру печени лишь самцов лабораторных животных [21,22]. Нами не обнаружено исследований, посвящённых изучению гендерных различий влияния ХАИ и темновой депривации на печень млекопитающих.…”

Section: оригинальные исследованияunclassified

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The effects of dark deprivation and chronic alcohol intoxication on the liver of rats

Areshidze,

Kaktursky,

Mikhaleva

et al. 2024

Morphology

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Summary. Light pollution, which causes melatonin deficiency and disruption of circadian rhythm, is associated with the development of a number of liver pathologies. A significant lack of melatonin against the background of a mismatch in the daily rhythm of vital processes leads to an increase in the susceptibility of the liver to alcohol-induced damage and an increase in the severity of alcoholic illness. The purpose of the study was to study the combined effect of constant lighting and chronic alcohol intoxication (CAI) on the liver structure of rats of both sexes. The study was conducted on 120 male and 80 female outbred Wistar rats at the age of 6 months. The duration of the experiment was 3 weeks. Both chronic alcohol intoxication and dark deprivation cause similar morphological changes in the liver of rats of both sexes, manifested in the development of fatty degeneration, necrosis and increased apoptotic activity of hepatocytes. The combined effect of these factors causes more pronounced changes in the structure of the liver of males, manifested in the development of cirrhotic changes in 13.3% of them, and toxic hepatitis in 20%, while in females signs of alcoholic hepatitis are observed in only 5% of animals. Increased expression of Ki-67 in hepatocytes of males is detected only under the combined action of chronic alcohol intoxication and dark deprivation, while in females an increase in expression is observed both under the separate and combined action of these factors. The data obtained allow us to conclude that liver adaptation to the separate and combined effects of CAI and dark deprivation is more successful in female rats than in males.

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Section: Discussionunclassified

Section: оригинальные исследованияunclassified

The effects of dark deprivation and chronic alcohol intoxication on the liver of rats

Areshidze,

Kaktursky,

Mikhaleva

et al. 2024

Morphology

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The role of light pollution in mammalian metabolic homeostasis and its potential interventions: A critical review

Guan

Wang²,

Cao³

et al. 2022

Environmental Pollution

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Diurnal dynamics of rat blood electrolytes at constant lighting and chronic alcohol intoxication

Kirillov

Makartseva

Kozlova

et al. 2022

Medical academic journal

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BACKGROUND: Violation of the lighting regime, as well as alcohol abuse, is significant factors in the disorganization of biorhythms in the modern world. Violation of rhythm leads to a mismatch of body functions, as a result to disadaptation, the occurrence of desynchronosis and the development of a number of socially significant diseases. AIM: Study of influence of constant lighting, chronic alcohol intoxication and joint action of these factors on diurnal dynamics of several electrolytes in blood of rats. MATERIALS AND METHODS: The study was conducted on 160 male of Wistar outbred stock at age of 6 months, with body weight of 300 20 g, which were divided into 4 groups. Control group animals, which were kept under conditions of fixed light regime (light:darkness = 10:14 hours), I group animals, which were kept under conditions of fixed light regime, but received a 15% water solution of ethanol as a drink, II group animals, which were kept under conditions of constant light regime, III group animals, which were kept under conditions of constant light regime and received a 15% water solution of ethanol as a drink. In blood samples, taken at 9:00, 15:00, 21:00 and 3:00 oclock, the concentration of total calcium, potassium, sodium, chlorine and phosphorus was measured. The reliability of circadian rhythmicity was determined through cosinor analysis. RESULTS: The increase in the concentration of phosphorus in the blood plasma of animals of II and III experimental groups was found with the decrease in the concentration of total calcium in animals of I and III experimental groups. Constant lighting and chronic alcohol intoxication affect the amplitude-phase characteristics of the circadian rhythms of all studied ions, and the combined action of these factors causes the destruction of the circadian rhythms of the studied electrolytes. CONCLUSIONS: It is established that the three-weeks-long influence of the studied chronodestructors leads to disruptions in metabolism of calcium and phosphorus, which are the most pronounced at joint action of darkness deprivation and chronic alcohol intoxication, and also to the significant disruptions in the structure of CRs of all of studied substances.

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Morphofunctional State and Circadian Rhythms of the Liver under the Influence of Chronic Alcohol Intoxication and Constant Lighting

Cited by 8 publications

References 72 publications

The effects of dark deprivation and chronic alcohol intoxication on the liver of rats

The effects of dark deprivation and chronic alcohol intoxication on the liver of rats

The role of light pollution in mammalian metabolic homeostasis and its potential interventions: A critical review

Diurnal dynamics of rat blood electrolytes at constant lighting and chronic alcohol intoxication

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