Morphofunctional State of the Periodontal Tissues in Humans and Rats with Arterial Hypertension

Kolesnikova, L. R.; Darenskaya, M. A.; Колесникова, Л. И.; Grebenkina, L. A.; Korytov, L. I.; Batoroev, Y. K.; Belinskaya, E. I.; Mikhalevich, I. M.; Колесников, С. И.

doi:10.1007/s10517-020-04990-8

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“…That is why one of the pathogenetic factors in the development of periodontitis is a violation of microcirculation in periodontal tissues. Hemomicrocirculatory disorders cause the development of metabolic disorders in the periodontium, dystrophic and degenerative changes, initiate inflammatory reactions [19]. These factors lead to damage to the vascular wall, an increase in the number of dormant capillaries, parietal prolapse of thrombotic masses, disruption of transport systems in the walls of blood vessels, and others.…”

Section: Discussionmentioning

confidence: 99%

Morphological Changes of Periodontal Components Under Experimental Lipopolysaccharide Periodontitis Combined With Hyperthyroidism

et al. 2022

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The aim: Investigate structural changes in the tissues of the periodontal complex under the condition of experimental lipopolysaccharide periodontitis combined with hyper¬thyroidism. Materials and methods: The studies were performed on adult white male rats, which simulated periodontitis combined with hyperthyroidism. Periodontal tissues were subjected to morphological examination on the 22nd day of the experiment. Collection of material for microscopic examinations was performed according to the generally accepted method; histological specimens were studied using a light optical microscope. Results: Morphological studies of the components of the periodontal complex of experimental animals with experimental periodontitis established the reorganization of its structural elements. Damage to the epithelium in the area of attachment of the circular ligament and erosive-ulcerative changes of the gums led to a deepening of the gingival sulcus with the formation of a deep periodontal pocket. Intense hyperkeratosis was observed in the area of the bottom of the periodontal pocket. In the own plate of the mucous membrane of the gums – significant edema, collagen fibers were disorganized, defragmented. There were pronounced destructive-degenerative and inflammatory changes of the epithelial and own plates of all areas of the gums and periodontium, damage to the nuclei and cytoplasm of keratinocytes, fibroblasts, and leukocytes. Conclusions: Experimental periodontitis combined with hyperthyroidism is accompanied by pronounced signs of destructive and inflammatory changes in the soft and dense tissues of the periodontal complex, as well as disruption of stromal-vascular interactions, which progress from reversible to irreversible disruption of periodontal connective tissue.

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Section: Discussionmentioning

confidence: 99%