1995
DOI: 10.1016/0955-0674(95)80102-2
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Morphogenetic roles of classic cadherins

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Cited by 1,361 publications
(1,036 citation statements)
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References 68 publications
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“…During the invasive process, tumour cells not only lose their cell-cell adhesion properties but also frequently undergo profound changes in their phenotype known as epithelial-mesenchymal transitions (EMTs) (Behrens et al, 1992;Christofori and Semb, 1999), a process reminiscent of EMT occurring at determined stages of development (Nieto, 2002;Thiery, 2002). The Ecadherin/catenin complexes represent the main adhesion system responsible for the maintenance of cell-cell contacts in epithelial tissues (Takeichi, 1995;Huber et al, 1996). Downregulation of E-cadherin expression or functional perturbations of the E-cadherin/catenin complexes frequently occur during the progression of carcinomas (Takeichi, 1993;Birchmeier and Behrens, 1994;Christofori and Semb, 1999), and has been casually linked to the progression of adenoma to invasive carcinoma (Perl et al, 1998).…”
Section: Introductionmentioning
confidence: 99%
“…During the invasive process, tumour cells not only lose their cell-cell adhesion properties but also frequently undergo profound changes in their phenotype known as epithelial-mesenchymal transitions (EMTs) (Behrens et al, 1992;Christofori and Semb, 1999), a process reminiscent of EMT occurring at determined stages of development (Nieto, 2002;Thiery, 2002). The Ecadherin/catenin complexes represent the main adhesion system responsible for the maintenance of cell-cell contacts in epithelial tissues (Takeichi, 1995;Huber et al, 1996). Downregulation of E-cadherin expression or functional perturbations of the E-cadherin/catenin complexes frequently occur during the progression of carcinomas (Takeichi, 1993;Birchmeier and Behrens, 1994;Christofori and Semb, 1999), and has been casually linked to the progression of adenoma to invasive carcinoma (Perl et al, 1998).…”
Section: Introductionmentioning
confidence: 99%
“…In adherens junctions, b-catenin and plakoglobin independently associate with the cytoplasmic domain of adhesion receptors of the cadherin family, linking them to the actin cytoskeleton via an association with a-catenin (Takeichi, 1990;Geiger and Ayalon, 1992;Kemler, 1993;Adams and Nelson, 1998;Takeichi, 1995). In addition to this structural role in cell adhesion, bcatenin and its Drosophila homolog, armadillo, are key components of the wg/wnt-signaling pathway (Peifer and Wieschaus, 1990;Peifer et al, 1993;Wodarz and Nusse, 1998) that regulates developmental processes, including speci®cation of the anterior-posterior segment polarity in Drosophila (Peifer et al, 1993), and axis determination in developing Xenopus embryos (Heasman et al, 1994).…”
Section: Introductionmentioning
confidence: 99%
“…At cell-cell junctions, adherens junction plays particularly an important role in the sense that the formation of other cell junctions are dependent on the formation of adherens junction (for reviews, see Geiger and Ginsberg, 1991;Tsukita et al, 1992;Takeichi, 1995). At adherens junction, cadherins interact with each other at the extracellular surface and serve as adhesion molecules (for reviews, see Geiger and Ginsberg, 1991;Tsukita et al, 1992;Takeichi, 1995).…”
Section: Introductionmentioning
confidence: 99%
“…At cell-cell junctions, adherens junction plays particularly an important role in the sense that the formation of other cell junctions are dependent on the formation of adherens junction (for reviews, see Geiger and Ginsberg, 1991;Tsukita et al, 1992;Takeichi, 1995). At adherens junction, cadherins interact with each other at the extracellular surface and serve as adhesion molecules (for reviews, see Geiger and Ginsberg, 1991;Tsukita et al, 1992;Takeichi, 1995). Cadherins indirectly interact at the cytoplasmic region with the actin cytoskeleton through many peripheral membrane proteins, including a-, b-, and g-catenins, p120, a-actinin, vinculin, neurabin, and afadin (Vestweber and Kemler, 1984;Peyrieras et al, 1985;Ozawa et al, 1989;Shibamoto et al, 1995;Nakanishi et al, 1997;Mandai et al, 1997).…”
Section: Introductionmentioning
confidence: 99%