Morphologic and Functional Connectivity Alterations of Corticostriatal and Default Mode Network in Treatment-Naïve Patients with Obsessive-Compulsive Disorder

Hou, Jingming; Song, Lingheng; Zhang, Wei; Wu, Wenjing; Wang, Jian; Zhou, Dan; Qu, Wei; Guo, Junwei; Gu, Shanshan; He, Mei; Xie, Bing; Li, Haitao

doi:10.1371/journal.pone.0083931

Cited by 63 publications

(43 citation statements)

References 83 publications

(100 reference statements)

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“…These findings are consistent with an overactive error control system in OCD subserving suppression of prepotent responses during decision-making. Several studies of FC connectivity confirmed alteration in the fronto-striato-thalamo-cortical (i.e., [199][200][201][202][203][204][205][206][207]). The dysregulation of the fronto-striato-thalamo-cortical circuit may be one of the major findings, which can help to differentiate the two disorders, as the presence of an increased WM integrity during in pediatric and adolescent patients affected by OCD.…”

Section: Developmental Perspectivementioning

confidence: 94%

Corticolimbic connectivity as a possible biomarker for bipolar disorder

Vai¹,

Bollettini²,

Benedetti³

2014

Expert Review of Neurotherapeutics

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Bipolar disorder is a severe, disabling and life-threatening illness, which affects nearly 2% of the general population. The identification of reliable and objective biomarkers may aid early diagnosis and optimize treatment efficacy. Through a careful overview of the neuroimaging studies which investigated the structural, functional, and effective connectivity in bipolar disorder, we explored the role of a disconnected cortico-limbic circuitry in the development and maintenance of the disorder. This review offers perspectives and suggestions for future research, in order to propose the corticolimbic disconnection as a neurobiological underpinning and biomarker for bipolar psychopathology.

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Section: Developmental Perspectivementioning

confidence: 94%

Corticolimbic connectivity as a possible biomarker for bipolar disorder

Vai¹,

Bollettini²,

Benedetti³

2014

Expert Review of Neurotherapeutics

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“…Within nodes of the SN, volumetric changes have been identified in the ACC, striatum and thalamus (Gilbert et al, 2008; Hoexter et al, 2012; Hou et al, 2013; Atmaca et al, 2016). Functionally, the ACC appears to be abnormally altered during disease-relevant tasks.…”

Section: Abnormalities Of Sn-cstc Loop Circuits In Psychiatric Illnessesmentioning

confidence: 99%

Cortico-Striatal-Thalamic Loop Circuits of the Salience Network: A Central Pathway in Psychiatric Disease and Treatment

Peters

Dunlop

Downar³

2016

Front. Syst. Neurosci.

462

298

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The salience network (SN) plays a central role in cognitive control by integrating sensory input to guide attention, attend to motivationally salient stimuli and recruit appropriate functional brain-behavior networks to modulate behavior. Mounting evidence suggests that disturbances in SN function underlie abnormalities in cognitive control and may be a common etiology underlying many psychiatric disorders. Such functional and anatomical abnormalities have been recently apparent in studies and meta-analyses of psychiatric illness using functional magnetic resonance imaging (fMRI) and voxel-based morphometry (VBM). Of particular importance, abnormal structure and function in major cortical nodes of the SN, the dorsal anterior cingulate cortex (dACC) and anterior insula (AI), have been observed as a common neurobiological substrate across a broad spectrum of psychiatric disorders. In addition to cortical nodes of the SN, the network’s associated subcortical structures, including the dorsal striatum, mediodorsal thalamus and dopaminergic brainstem nuclei, comprise a discrete regulatory loop circuit. The SN’s cortico-striato-thalamo-cortical loop increasingly appears to be central to mechanisms of cognitive control, as well as to a broad spectrum of psychiatric illnesses and their available treatments. Functional imbalances within the SN loop appear to impair cognitive control, and specifically may impair self-regulation of cognition, behavior and emotion, thereby leading to symptoms of psychiatric illness. Furthermore, treating such psychiatric illnesses using invasive or non-invasive brain stimulation techniques appears to modulate SN cortical-subcortical loop integrity, and these effects may be central to the therapeutic mechanisms of brain stimulation treatments in many psychiatric illnesses. Here, we review clinical and experimental evidence for abnormalities in SN cortico-striatal-thalamic loop circuits in major depression, substance use disorders (SUD), anxiety disorders, schizophrenia and eating disorders (ED). We also review emergent therapeutic evidence that novel invasive and non-invasive brain stimulation treatments may exert therapeutic effects by normalizing abnormalities in the SN loop, thereby restoring the capacity for cognitive control. Finally, we consider a series of promising directions for future investigations on the role of SN cortico-striatal-thalamic loop circuits in the pathophysiology and treatment of psychiatric disorders.

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“…Although these inconsistencies might be due to the clinical characteristics of each dataset 25,26 , other studies suggested that the fronto-striatal circuit is not the only target should be considered. In other words, studies have suggested that there were abnormalities in addition to those observed in the fronto-striatal circuit, including the frontoparietal and default mode networks 5,27,28 . No study has quantitatively evaluated the relative importance of the fronto-striatal circuit relative to the whole brain.…”

mentioning

confidence: 99%

A Neural Marker of Obsessive-Compulsive Disorder from Whole-Brain Functional Connectivity

Takagi

Sakai

Lisi

et al. 2017

Sci Rep

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Obsessive-compulsive disorder (OCD) is a common psychiatric disorder with a lifetime prevalence of 2–3%. Recently, brain activity in the resting state is gathering attention for exploring altered functional connectivity in psychiatric disorders. Although previous resting-state functional magnetic resonance imaging studies investigated the neurobiological abnormalities of patients with OCD, there are concerns that should be addressed. One concern is the validity of the hypothesis employed. Most studies used seed-based analysis of the fronto-striatal circuit, despite the potential for abnormalities in other regions. A hypothesis-free study is a promising approach in such a case, while it requires researchers to handle a dataset with large dimensions. Another concern is the reliability of biomarkers derived from a single dataset, which may be influenced by cohort-specific features. Here, our machine learning algorithm identified an OCD biomarker that achieves high accuracy for an internal dataset (AUC = 0.81; N = 108) and demonstrates generalizability to an external dataset (AUC = 0.70; N = 28). Our biomarker was unaffected by medication status, and the functional networks contributing to the biomarker were distributed widely, including the frontoparietal and default mode networks. Our biomarker has the potential to deepen our understanding of OCD and to be applied clinically.

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Morphologic and Functional Connectivity Alterations of Corticostriatal and Default Mode Network in Treatment-Naïve Patients with Obsessive-Compulsive Disorder

Cited by 63 publications

References 83 publications

Corticolimbic connectivity as a possible biomarker for bipolar disorder

Corticolimbic connectivity as a possible biomarker for bipolar disorder

Cortico-Striatal-Thalamic Loop Circuits of the Salience Network: A Central Pathway in Psychiatric Disease and Treatment

A Neural Marker of Obsessive-Compulsive Disorder from Whole-Brain Functional Connectivity

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