Morphologic and molecular analysis of Richter syndrome in chronic lymphocytic leukaemia patients treated with ibrutinib or venetoclax

Abstract

Pathology (-xxxx) xxx(xxx), xxx Please cite this article as: Gángó A et al., Morphologic and molecular analysis of Richter syndrome in chronic lymphocytic leukaemia patients treated with ibrutinib or venetoclax, Pathology,

Molecular characterization and clonal evolution in Richter transformation: Insights from a case of plasmablastic lymphoma (RT‐PBL) arising from chronic lymphocytic leukaemia (CLL) and review of the literature

“…A review of the literature on PBL arising in the context of CLL yielded 15 cases [2, 7–16], the findings of which are summarized in Table S4. The male‐to‐female ratio was 4:1 and age at primary CLL diagnosis ranged from 52 to 77 years.…”

“…FISH analysis was conducted on nine cases of CLL [2, 7–9], with the most common alterations being 17p13.1 abnormalities (4/9), followed by 13q14.3 deletions (3/9). Trisomy 12 was detected in two cases, and 11q22 deletion was found in one.…”

“…One CLL case had a t(12;14). rearrangement with MYC rearrangement at transformation, whereas the second case had an MYC rearrangement, which persisted in the subsequent PBL [7]. Four of seven cases that underwent MYC rearrangement studies on PBL were positive.…”

“…A review of the literature on PBL arising in the context of CLL yielded 15 cases [2,[7][8][9][10][11][12][13][14][15][16], the findings of which are summarized in and a 17p13.1 deletion, along with a TP53 mutation. 14 In two cases, FISH analysis was performed for BCL2, BCL6, CCND1, MYC and TP53 abnormalities in both the CLL and PBL.…”

“…Three cases had both CLL and months. Of the 14 tested cases, 11 were negative for EBV, and 3 were positive.FISH analysis was conducted on nine cases of CLL[2,[7][8][9], with the most common alterations being 17p13.1 abnormalities (4/9), followed by 13q14.3 deletions (3/9). Trisomy 12 was detected in two cases, and 11q22 deletion was found in one.…”