Morphologic Evaluation of P53 Apoptotic Signaling Responses and Proliferative Activity of Ki-67 in Oral Lichen Planus, Oral Squamous Cell Carcinoma and Normal Specimens

Fakhrjou, Ashraf; Toutounchi, Seyed Javad Seyed

doi:10.3923/jms.2012.51.56

Cited by 3 publications

(5 citation statements)

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“…In terms of geographical variance, it is documented that the people living near the equator appear to have a greater frequency of Pro alleles compared to populations inhabiting the nations farther North. There are also considerable racial and ethnic differences in the genotype pattern of the p53 codon 72 polymorphism [4,6]. Fakhrjou et al found that the rate of p53 expression in OLP was higher than in normal counterparts in the Iranian population.…”

Section: Discussionmentioning

confidence: 99%

“…Squamous epithelial cells in the oral cavity are infected by the Human Papillomavirus (HPV) E6 and E7 oncoproteins, which are crucial for oncogenesis in cervical cancer, driven by high-risk strains of HPV-16/18 [4,5]. Patients with both wild-type and p53 mutations were shown to have high-risk HPV infection [6]. The E6 and E7 viral proteins expressed by the two high-risk HPV-16/18 strains interact in unison in the degeneration of keratinocytes and are essential for maintaining the oncogenic phenotype.…”

Section: Introductionmentioning

confidence: 99%

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Role of Polymorphism of p53 Gene Codon 72 in HPV-associated oral lichen planus in south Indian population

Vijayan

Muthukrishnan

2022

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Background: High-risk Human Papillomavirus infections, and polymorphism of the p53 gene, have been implicated in oral potentially malignant disorders. The present study determines whether the polymorphism at codon 72 of the p53 gene and the presence of HPV-16/18 strains are associated with OLP patients. Materials and methods: The biopsy specimens were obtained from 250 OLP individuals. The samples were processed for HPV-DNA analysis and polymorphism of the p53 gene using PCR. Data were analyzed by applying the Chi-square test. Results: There were 103 positive HPV sample specimens with 34 males and 69 females which were shown to be statistically significant (p<0.001). Arg/Arg, Pro/Pro, and Arg/Pro were found in 19.4%, 31.1%, and 50% of HPV-positive cases of OLP, respectively, compared to 17%, 47%, and 36% of HPV-negative samples, which were found to be statistically significant between the two groups. The Arginine allele (44%) was more prevalent in HPV-associated OLP than in HPV-negative OLP cases (35%) which was found to be statistically significant between the groups. Conclusion: The results of the current study relate to the premalignant potential of OLP based on the occurrence of codon 72 of the p53 gene polymorphism in HPV-associated OLP patients in terms of genotype and allele.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Role of Polymorphism of p53 Gene Codon 72 in HPV-associated oral lichen planus in south Indian population

Vijayan

Muthukrishnan

2022

ijhs

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“…Mutations in the TP53 gene are the most common molecular defects in OSCC and it is essential for the initial phase of oral cancers. [18][19][20][21][22] The lack of correlation between the OSCC tumor grade and the p53 expression in the current study can be attributed to their poorly differentiation. However, patients in previous studies were predominantly well and moderately differentiated.…”

Section: Fig 1 the Immunoexpression Of P53 Protein In Oscc Tissue A) ...mentioning

confidence: 99%

“…Our observations are similar to the results obtained from previous studies in Iran. Fakhrjou A, Toutounchi SJ (2012) 18 performed a study on two groups of OSCC lesions and the buccal mucosa of normal subjects, 20 per each group, and showed a higher rate of p53 positivity in OSCC subjects in comparison to the control group (100% vs. 40%). A case-control study conducted on 25 cases of well-differentiated OSCC and 22 samples from patients with erosive oral lichen planus (OLP) also presented a significant difference in the expression of p53 protein (49.6±29.6% in OSCC vs. 30.86±28.26% in OLP).…”

Section: Fig 1 the Immunoexpression Of P53 Protein In Oscc Tissue A) ...mentioning

confidence: 99%

“…In Iranian population, OSCC is a common cancer; however, a few studies with limited scopes have investigated the correlation of p53 protein expression with development and progression of OSCCs in Iranian patients. [18][19][20][21][22] Besides, and to the best of our knowledge, there isn't any published study regarding the possible changes in the expression of mutant p53 protein between OSCC patients with the primary and recurrence tumors. Therefore, this study for the first time, aimed to compare the pattern of p53mt protein expression in Iranian patients with primary and recurrence OSCC.…”

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confidence: 99%

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Immunoexpression of p53 mutant-type in Iranian patients with primary and recurrence oral squamous cell carcinoma

Danesteh

Sadeghzadeh²,

Mokhtari³

et al. 2022

Eur J Transl Myol

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Mutations in tumor suppressor p53 protein can occur at different phases of malignant transformation and affect the patient's prognosis. This study aimed to evaluate the expression of mutant p53 protein in Iranian patients with the primary and recurrence oral squamous cell carcinoma (OSCC). This retrospective cross-sectional study conducted on a group of patients with the primary OSCC (n=122) and the control subjects with oral noncancerous reactive lesions (n=80). Immunohistochemistry was performed with the DO-7 monoclonal antibody against p53 protein, and samples with ≥10% immunostaining were considered positive. Statistical analyses were carried out using SPSS. Positive staining for p53 was observed in none of the control subjects and 57.4% (70 of 122) of the primary OSCC patients (p<0.0001, OR=107.69, 95%CI=6.49-179.0). The p53 immunopositivity had no significant differences between males and females (54.2% vs. 62%, p=0.390), but significantly different between those aged below and over 50 years (p<0.0001, OR=4.52, 95%CI=1.07-12.05). During follow-up, OSCC recurrence occurred in 104 patients, but the phenotype of the mutant p53 protein in patients who relapsed was the same as in matched primary tumors (p=0.763). Risk of recurrence had no significant differences between p53-positive and p53-negative cases (p=0.953), males and females (p=0.263), and age below and over 50 years (p=0.223). Despite its confirmed diagnostic value, the immunoexpression of the p53 mutant protein in OSCC in cancer recurrence was the same as in the primary tumor. However, further studies with a larger sample size and longer follow-up are needed to confirm or change our conclusions.

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Malignant transformation of oral lichen planus and related genetic factors

Hwang¹,

Choi²,

Kim³

2020

Intern. J. Oral Biol.

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Morphologic Evaluation of P53 Apoptotic Signaling Responses and Proliferative Activity of Ki-67 in Oral Lichen Planus, Oral Squamous Cell Carcinoma and Normal Specimens

Cited by 3 publications

References 24 publications

Role of Polymorphism of p53 Gene Codon 72 in HPV-associated oral lichen planus in south Indian population

Role of Polymorphism of p53 Gene Codon 72 in HPV-associated oral lichen planus in south Indian population

Immunoexpression of p53 mutant-type in Iranian patients with primary and recurrence oral squamous cell carcinoma

Malignant transformation of oral lichen planus and related genetic factors

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