Morphologic, immunologic and cytogenetic studies in acute myeloid leukemia following occupational exposure to pesticides and organic solvents

Cuneo, Antonio; Pazzi, Isabella; Tallarico, Antonella; Previati, Rita; Piva, Nadia; Carli, Maria Gretel; Balboni, Massimo; Castoldi, Gianluigi

doi:10.1016/0145-2126(92)90158-4

Cited by 48 publications

(14 citation statements)

References 24 publications

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“…However, a more recent detailed study failed to find such a firm association between cytogenetic changes in chromosomes 5 and 7 and occupational exposure to organic chemicals, although these changes may be associated with exposure to paints (Crane et al, 1996). Additional studies in leukemias associated with exposure to organic chemicals have detected many of the other major changes found in AML (e.g., t(8;21), t(11q23), and trisomy 8) in addition to changes in chromosomes 5 and 7 (Albin et al, 2000;Crane et al, 1989;Cuneo et al, 1992;Li et al, 1989). Thus, recent research does not appear to support an exclusive association between cytogenetic changes in chromosomes 5 and 7 and occupational exposure to organic chemicals.…”

Section: Comparison Of Benzene To Other Leukemogensmentioning

confidence: 77%

“…In contrast to the case reports described above, several large-scale leukemia studies have been conducted that surveyed their subjects for information on prior chemical exposures (Cuneo et al, 1992;Golomb et al, 1982;Groupe, 1984;Iurlo et al, 1989;Li et al, 1989;Mitelman et al, 1978;Mitelman et al, 1981;Richardson et al, 1992). These studies compared chromosome changes in leukemia patients with various occupational chemical exposures and in those without exposure.…”

Section: F Chromosome Changes In Leukemia Patients With Likely Priormentioning

confidence: 99%

“…Several studies have found an association between CA and chemical exposure among leukemia patients (Crane et al, 1989;Cuneo et al, 1992;Golomb et al, 1982;Groupe, 1984), although several negative studies have been reported (Ciccone et al, 1993;Vineis et al, 1990). Early reports suggested that occupational exposure to chemicals was associated, like exposure to alkylating agents, with changes in chromosomes 5 and 7 (Golomb et al, 1982;Groupe, 1984;Mitelman et al, 1978).…”

Section: Comparison Of Benzene To Other Leukemogensmentioning

confidence: 99%

See 2 more Smart Citations

The Nature of Chromosomal Aberrations Detected in Humans Exposed to Benzene

Zhang¹,

Eastmond

Smith³

2002

Critical Reviews in Toxicology

151

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Section: Comparison Of Benzene To Other Leukemogensmentioning

confidence: 77%

Section: F Chromosome Changes In Leukemia Patients With Likely Priormentioning

confidence: 99%

Section: Comparison Of Benzene To Other Leukemogensmentioning

confidence: 99%

See 1 more Smart Citation

The Nature of Chromosomal Aberrations Detected in Humans Exposed to Benzene

Zhang¹,

Eastmond

Smith³

2002

Critical Reviews in Toxicology

151

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“…T (8;21) occasionally occurs in leukemias associated with prior exposure to cancer chemotherapy of both alkylator and topoisomerase II inhibitor activity, 8,[25][26][27][28][29] and has also been reported in leukemias associated with certain occupational exposures. [30][31][32][33] AML1 is occasionally fused to other partners in therapy-related leukemias, including EVI-1/MDS/EAP, MTG16, and other partners in chromosomes 1, 12, 14 and others. 9,34,35 AML1-ETO fusion produces a chimeric oncoprotein consisting of the runt-homology domain of AML1 on chromosome 21 fused to nearly the entire gene of ETO on chromosome 8.…”

Section: Introductionmentioning

confidence: 99%

Molecular characterization of genomic AML1-ETO fusions in childhood leukemia

et al. 2001

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T(8;21) AML1(CBFA2)-ETO(MTG8)is the most common chromosomal translocation in acute myeloid leukemia (AML) in both children and adults. We sought to understand the structure and gain insight into the fusion process between AML1 and ETO by sequencing genomic fusions in 17 primary childhood AMLs and two cell lines with t(8;21). Reciprocal translocations were sequenced for seven of the 19 samples. We assumed a null hypothesis that the translocation breakpoints would be evenly distributed along the intronic breakpoint cluster regions. Testing for multimodality via smoothed bootstrap statistical methods suggested, however, the presence of two separate cluster regions within both the AML1 and ETO breakpoint cluster regions. ETO breakpoints were predominantly located in intron 1B in a defined cluster 5Ј of exon 1A (scan statistic P value = 0.00001). All patients with available RNA expressed an AML1-ETO mRNA fusion between exon 5 of AML1 and exon 2 of ETO. Since the structural restraints for the fusion protein of AML1-ETO exclude exon 1A, we reason that ETO intron 1B harbors a structural feature with propensity for breakage and/or recombination. Chromosomal breakpoints displayed evidence of fusion by a non-homologous end joining process, with microhomologies and nontemplate nucleotides at some fusion junctions. Breakpoints in general displayed similar complexity of duplications, deletions, and insertions to other common pediatric leukemia translocations (TEL-AML1, MLL-AF4, PML-RARA, CBFB-MYH11) that we and others have analyzed. Leukemia (2001Leukemia ( ) 15, 1906Leukemia ( -1913

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“…Characteristic chromo-some rearrangements in leukemia patients have been associated with past exposure to tobacco smoke, solvents, and pesticides [Cuneo et al, 1992;Crane et al, 1996;Davico et al, 1998;Alexander et al, 2001]. Polymorphisms in certain genes involved in the metabolism of various environmental chemicals also have been associated with particular chromosome alterations [Larson et al, 1999;Wiemels et al, 1999].…”

Section: Introductionmentioning

confidence: 99%

Fluorescence in situ hybridization is necessary to detect an association between chromosome aberrations and polycyclic aromatic hydrocarbon exposure in utero and reveals nonrandom chromosome involvement

Bocskay

Orjuela

Tang

et al. 2007

Environ and Mol Mutagen

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Chromosome aberrations are associated with environmental exposures in infants and children. Recently we reported that prenatal exposure to airborne polycyclic aromatic hydrocarbons (PAHs) was significantly (P < 0.01) associated with stable aberration frequencies in cord blood from a subset of 60 newborns from the Columbia Center for Children's Environmental Health Prospective Cohort Study (Bocskay K et al. [2005]: Cancer Epidemiol Biomarkers Prev 14:506-511). To determine whether the environmental exposures may be targeting specific chromosomes and to compare various methods for measuring chromosome aberrations, we further evaluated this same subset of subjects composed of African-American and Dominican nonsmoking mother-newborn pairs residing in low-income neighborhoods of New York City, and exposed to varying levels of airborne PAHs. Chromosome aberrations were measured in cord blood lymphocytes, both by whole chromosome probe (WCP) fluorescence in situ hybridization (FISH) and traditional Giemsa-staining. Prenatal exposures were assessed by personal air monitoring. Breaks in chromosomes 1-6, as detected by WCP FISH, were nonrandomly distributed, underscoring the importance of appropriate chromosome probe selection to capture cytogenetic damage in response to exposure. FISH for stable aberrations was found to be a more sensitive method for detecting aberration frequencies associated with environmental exposures, when compared with FISH for unstable aberrations or Giemsa-staining for aberrations. Together, these results suggest that PAHs may be targeting specific chromosomes and highlight the importance of using the more sensitive detection methods to assess risk in populations with low levels of exposure.

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Morphologic, immunologic and cytogenetic studies in acute myeloid leukemia following occupational exposure to pesticides and organic solvents

Cited by 48 publications

References 24 publications

The Nature of Chromosomal Aberrations Detected in Humans Exposed to Benzene

The Nature of Chromosomal Aberrations Detected in Humans Exposed to Benzene

Molecular characterization of genomic AML1-ETO fusions in childhood leukemia

Fluorescence in situ hybridization is necessary to detect an association between chromosome aberrations and polycyclic aromatic hydrocarbon exposure in utero and reveals nonrandom chromosome involvement

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