Morphologic, Patient and Interpreter Profiles of High-Risk Human Papillomavirus–Positive vs. –Negative Cases of Atypical Squamous Cells of Undetermined Significance

Steinman, Sharon; Smith, Deborah; Chandler, Nancy; Dhurandhar, Bakula; Filippo, Liza S Di; Scheiber-Pact, Miriam; Mody, Dina R.

doi:10.1159/000325507

Cited by 5 publications

(4 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Much has been learnt from examining borderline changes in hrHPV-negative and -positive triage samples. 31 Furthermore, knowledge of HPV status has been shown to improve the accuracy of co-testing. 32 The benefits and disadvantages of blind versus revealed co-testing could only be demonstrated in practice if slides were at least available for hrHPV-negative cases.…”

Section: Practical Implications Of Co-testingmentioning

confidence: 99%

Primary HPV testing: a proposal for co‐testing in initial rounds of screening to optimise sensitivity of cervical cancer screening

Herbert

2016

Cytopathology

View full text Add to dashboard Cite

As explained by Kitchener in a previous issue of Cytopathology (2015;26:4-6), primary human papillomavirus (HPV) testing is likely to be introduced in the UK for all women aged 25-64 years following pilot site studies already in place. This will be necessary when the prevalence of cervical cancer and its precursors declines when vaccination takes effect but there is a risk in abandoning cytology as a primary test: a risk that would be most apparent in the present unvaccinated population in which the prevalence of cervical cancer and its precursors is exceptionally high. HPV testing is more sensitive than cytology but has a significant false-negative rate that could be detrimental to a successful screening programme if introduced without cytology backup. Accurate cytology would be needed for triage and could be compromised if HPV-negative tests were excluded from examination. This article proposes a compromise: cytology and HPV co-testing for the first two screening tests to optimise the sensitivity of the test as a whole. Registrations of invasive and in situ carcinoma of the uterine cervix in England indicate that the prevalence of the disease is highest in young women in the early rounds of screening. Calculations of the likely impact on the workload of this proposal have been based on a service evaluation of 295 cytology tests received at St Thomas' Hospital, which suggests that the volume of cytology tests would be reduced by approximately 60% compared with 80% for primary HPV testing alone. This proposal should be debated openly before irrevocable changes are made to a skilled workforce.

show abstract

Section: Practical Implications Of Co-testingmentioning

confidence: 99%

Primary HPV testing: a proposal for co‐testing in initial rounds of screening to optimise sensitivity of cervical cancer screening

Herbert

2016

Cytopathology

View full text Add to dashboard Cite

show abstract

“…However, as “concentric squamous whorls” usually has a small and dense pyknotic nucleus, we might be able to consider it as the sign of ASCUS, regardless of its nuclear feature. Steinman et al also suggested that parakeratosis was more frequently associated with hrHPV infection. “Concentric squamous whorls” is also a well‐recognized morphologic finding of the squamous papilloma associated with HPV infection …”

Section: Discussionmentioning

confidence: 99%

“…All tests were performed using the specimens from a single vial that was sampled at the same time from each patient. The DNA Chip test used in this study allows for detection of 15 high-risk HPV (hrHPV) genotypes (16,18,31,33,35,39,45,51,52,56,58,59,66, 68, and 69) and 7 low-risk HPV (lrHPV) groups (6, 11, 34, 40, 42, 43, and 44). The LMBA assay used in this study uses Luminex equipment and enables detection of 19 hrHPVs (16,18,26,31,33,35,39,45,51,52,53,56,58, 59, 66, 68, 69, 70, and 73) and 13 lrHPVs (6,11,32,34,40,42,43,44,54,55,62, 81, and 83) (Supporting Information Table 1).…”

Section: A Triple Hpv Testmentioning

confidence: 99%

Novel cytomorphologic characteristics suggesting human papillomavirus infection in patients diagnosed as negative for intraepithelial lesion or malignancy and a comparison of diagnostic performance of three human papillomavirus tests

Jin

Lee

Kim

et al. 2018

Diagnostic Cytopathology

View full text Add to dashboard Cite

show abstract

“…Despite these previous studies, there are also studies supporting a significant association of parakeratosis with HPV infection. Steinman et al found koilocytelike changes and parakeratosis more frequently associated with HR‐HPV. In an other study, the authors concluded that abortive koilocytes, mild dyskeratosis, mild nuclear hyperchromasia, bi/multinucleation, parakeratosis, and diffuse keratohyaline granules had the best correlation with the gold standard for detecting HPV infection ( P < 0.05).…”

Section: Discussionmentioning

confidence: 99%

The significance of parakeratosis alone in cervicovaginal cytology of turkish women

Kır

Sarbay

Şeneldir

2017

Diagnostic Cytopathology

View full text Add to dashboard Cite

Our results demonstrate that a finding of parakeratosis on an otherwise negative Pap smear supports a follow-up HPV DNA test. Also we should consider whether the presence of parakeratosis should be included in standard cytology reports. Additionally parakeratosis trended toward increased frequency of HSIL in follow-up biopsy specimens. But it did not reach statistical significance. That is why larger studies are necessary to evaluate the association of parakeratosis and HSIL in colposcopic biopsy specimens. Diagn. Cytopathol. 2017;45:297-302. © 2016 Wiley Periodicals, Inc.

show abstract

Morphologic, Patient and Interpreter Profiles of High-Risk Human Papillomavirus–Positive vs. –Negative Cases of Atypical Squamous Cells of Undetermined Significance

Cited by 5 publications

References 17 publications

Primary HPV testing: a proposal for co‐testing in initial rounds of screening to optimise sensitivity of cervical cancer screening

Primary HPV testing: a proposal for co‐testing in initial rounds of screening to optimise sensitivity of cervical cancer screening

Novel cytomorphologic characteristics suggesting human papillomavirus infection in patients diagnosed as negative for intraepithelial lesion or malignancy and a comparison of diagnostic performance of three human papillomavirus tests

The significance of parakeratosis alone in cervicovaginal cytology of turkish women

Contact Info

Product

Resources

About