Morphologic studies of connective tissue resorption in the tail fin of metamorphosing bullfrog tadpole

Usuku, Gentaro; Gross, Jerome

doi:10.1016/0012-1606(65)90044-8

Cited by 112 publications

(25 citation statements)

References 15 publications

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“…The manifold morphological changes in amphibian integument which accompany metamorphosis and the assumption of semiterrestrial life include keratinization of outer epidermal cells, increase in the number of epidermal cell layers, loss of Leydig cells, development of both mucous and granular skin glands, and gross alterations in the subepidermal connective tissue (see Kemp, 1961Kemp, , 1963Voute, 1963;Vanable, 1964;Usuku and Gross, 1965). Within the framework of these fairly obvious changes, the present study has disclosed two apparently simultaneous events involving the adhesive and adepidermal structures described above.…”

Section: Changes In Adhesion Sites and Adepidermal Structure At Metammentioning

confidence: 53%

“…Weiss andFerris (1954, 1956) (see also Porter, 1954) noted that during larval stages in amphibians this lucent zone is occupied by objects which they described as regularly dispersed "granules" of probable lipid nature. Singer and Salpeter (1961) (see also Usuku and Gross, 1965) also noted the presence of this adepidermal substance, and the further fact that it is lacking along the basal lamina in adult newts. However, other reports are equivocal as to the reality of the material, and whether it exists as globules or as filaments (see Hama, 1960; Chapman and Dawson,…”

Section: Adepidermal Components and The Couagenous Lamellaementioning

confidence: 83%

“…17 shows an area along the epidermaldermal junction in an animal fixed 3 to 4 weeks past emergence. By this stage, the junction has been thrown into an irregularly plicated border, beneath which is found a collagenous substrate no longer layered and h:ghly ordered (see Kemp, 1961Kemp, , 1963Usuku and Gross, 1965). Globular structures in the wide adepidermal lucent zone are absent.…”

Section: Changes In Adhesion Sites and Adepidermal Structure At Metammentioning

confidence: 99%

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Fine Structure of Desmosomes, Hemidesmosomes, and an Adepidermal Globular Layer in Developing Newt Epidermis

Kelly

1966

The Journal of Cell Biology

420

109

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A B S T R A C TThe skin of late embryonic, larval, and young postmetamorphic newts, Taricha torosa, has been examined with particular reference to areas of cellular attachment. Stereo electron microscopic techniques and special staining methods for extracellular materials were utilized in addition to conventional avenues of ultrastructural study to investigate the fine architecture of desmosomes, hemidesmosomes, their associated filament systems, and extracellular materials. No evidence has been found that continuity of tonofilaments between adjacent cells exists at desmosomes. Rather, most of the tonofilaments which approach desmosomes (and perhaps also hemidesmosomes) course toward the "attachment plaque" and then loop, either outside the plaque or within it, and return into the main filament tracts of the cell. These facts suggest that the filamentous framework provides intracellular tensile support while adhesion is a product of extracellular materials which accumulate at attachment sites. Evidence is presented that the extracellular material is arranged as pillars or partitions which are continuous with or layered upon the outer unit cell membrane leaflets and adjoined in a discontinuous dense midline of the desmosome. A similar analysis has been made of extracellular materials associated with hemidesmosomes along the basal surface of epidermal cells. An adepidermal globular zone, separating the basal cell boundary from the underlying basal lamina and collagenous lamellae during larval stages, has been interpreted from enzyme and solvent extraction study as a lipid-mucopolysaccharide ccmplex, the function of which remains obscure. These observations are discussed in relation to prevailing theories of cellular adhesion and epidermal differentiation. They appear consistent with the concept that a wide range of adhesive specializations exists in nature, and that the more highly organized of these, such as large desmosomes and hemidesmosomes, serve as strong, highly supported attachment sites, supplemental in function to a more generalized aggregating mechanism.

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Section: Changes In Adhesion Sites and Adepidermal Structure At Metammentioning

confidence: 53%

Section: Adepidermal Components and The Couagenous Lamellaementioning

confidence: 83%

Section: Changes In Adhesion Sites and Adepidermal Structure At Metammentioning

confidence: 99%

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Fine Structure of Desmosomes, Hemidesmosomes, and an Adepidermal Globular Layer in Developing Newt Epidermis

Kelly

1966

The Journal of Cell Biology

420

109

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“…The tail skin degeneration appears to be dermis-dependent because, when tail skin is transplanted to body regions, its dermis is restructured and the skin survives metamorphosis to turn into adult skin; on the other hand, any skin placed on tail dermis degenerates [35]. As in the intestine, the basement membrane between the epidermis and dermis of the tail thickens during metamorphosis [36]. We and Berry et al [28] have found that Col3 and ST3 are expressed by the sub-epithelial cells starting around stage 58, coincident with these changes.…”

Section: The Skinmentioning

confidence: 99%

“…The Col3 expressed in these cells may play a role in collagen fiber fraying early during tail resorption [36]. Although Col3 may also facilitate epidermal cell death in the tail, its expression is not tightly associated with apoptosis.…”

Section: The Skinmentioning

confidence: 99%

Spatial and temporal regulation of collagenases-3, -4, and stromelysin -3 implicates distinct functions in apoptosis and tissue remodeling during frog metamorphosis

1999

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Matrix metalloproteinases (MMPs) are a family of extracellular proteases capable of degrading various proteinaceous components of the extracellular matrix (ECM). They have been implicated to play important roles in a number of developmental and pathological processes, such as tumor metastasis and inflammation. Relatively few studies have been carried out to investigate the function of MMPs during postembryonic organ-development. Using Xenopus laevis development as a model system, we demonstrate here that three MMPs, stromelysin-3 (ST3), collagenases-3 (Col3), and Col4, have distinct spatial and temporal expression profiles during metamorphosis as the tadpole transforms into a frog. In situ hybridizations reveal a tight, but distinct, association of individual MMPs with tissue remodeling in the tail and intestine during metamorphosis. In particular, ST3 expression is strongly correlated with apoptosis in both organs as demonstrated by analyses of serial sections with in situ hybridization for ST3 mRNA and TUNEL (terminal deoxyribonucleotidyl transferase-mediated dUTP-biotin nick end labeling) for apoptosis, respectively. On the other

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Collagenolytic Activity in the Cornea of the Metamorphosing Tadpole

Slansky¹,

Tolpin²,

Webster³

1970

Archives of Ophthalmology

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Morphologic studies of connective tissue resorption in the tail fin of metamorphosing bullfrog tadpole

Cited by 112 publications

References 15 publications

Fine Structure of Desmosomes, Hemidesmosomes, and an Adepidermal Globular Layer in Developing Newt Epidermis

Fine Structure of Desmosomes, Hemidesmosomes, and an Adepidermal Globular Layer in Developing Newt Epidermis

Spatial and temporal regulation of collagenases-3, -4, and stromelysin -3 implicates distinct functions in apoptosis and tissue remodeling during frog metamorphosis

Collagenolytic Activity in the Cornea of the Metamorphosing Tadpole

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