2022
DOI: 10.1177/20406223221141354
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Morphological alterations of the hypothalamus in idiopathic intracranial hypertension

Abstract: Background: The pathophysiology of idiopathic intracranial hypertension (IIH), a condition characterized by raised intracranial pressure, is not well understood. Objectives: We hypothesized that the hypothalamus might exhibit alterations in patients with IIH, based on its established association with obesity and the potential role of hormonal and metabolic factors in IIH. Design: Retrospective single-center cohort study. Methods: Thirty-three individuals with IIH and 40 matched healthy individuals were studied… Show more

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Cited by 6 publications
(1 citation statement)
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“…Hormonal abnormalities were seen in 37.5%, with 20% having reduced systemic cortisol, not related to the presence of partial or empty sella (68.8%) [28]. Kassubek et al [29] retrospectively evaluated hypothalamic morphology and satiety hormones in IIH patients (n ¼ 33) vs. healthy matched controls (n ¼ 40). Only melatonin was significantly different in groups after BMI matching.…”
Section: Cause and Pathophysiologymentioning
confidence: 99%
“…Hormonal abnormalities were seen in 37.5%, with 20% having reduced systemic cortisol, not related to the presence of partial or empty sella (68.8%) [28]. Kassubek et al [29] retrospectively evaluated hypothalamic morphology and satiety hormones in IIH patients (n ¼ 33) vs. healthy matched controls (n ¼ 40). Only melatonin was significantly different in groups after BMI matching.…”
Section: Cause and Pathophysiologymentioning
confidence: 99%