Morphological analysis and quantitative evaluation of myopic maculopathy by three-dimensional magnetic resonance imaging

Abstract

PurposeTo study the characteristic morphology and quantitatively evaluate the eye shape in different types of myopic maculopathy.MethodsA total of 103 eyes from 65 patients with high myopic maculopathy were examined by spectral-domain optical coherence tomography (SD-OCT) and three-dimensional magnetic resonance imaging (3D MRI). The participants were classified into two groups, namely myopic traction maculopathy (MTM) eyes and non-MTM eyes, with SD-OCT imaging. Volume renderings and morphology analysis of the 3D MRI of the eyeball were obtained. Quantitative analysis was achieved in the calculation of vitreous volume and the three-dimensional diameters of the eyeball in three cardinal axes. The eye shape distribution and the diameters of the eyeball were compared between the two groups. Eye shape distribution, vitreous volume, and eyeball diameter were compared between MTM and non-MTM eyes.ResultsThe MTM and non-MTM groups had a total of 68 and 35 eyes, respectively. A significant difference was found in the eye shape distribution (P<0.0001) between MTM and non-MTM eyes. Most of the MTM eyes had undergone a non-uniform expansion of the eyeball, whereas the non-MTM eyes had expanded uniformly. There was no significant difference (P>0.05) in either vitreous volume or other diameters between the two groups.ConclusionsNon-uniform globe expansion and staphyloma formation might play an important role in the pathogenesis of MTM.

CHARACTERISTICS AND MANAGEMENT OF MYOPIC TRACTION MACULOPATHY IN MYOPIC EYES WITH AXIAL LENGTH LESS THAN 26.5 mm

“…In previous work, we reported that uneven expansion of the ocular globe with posterior staphyloma contributes to MTM. 5 We also observed that eyes with a dome-shaped macula had a weaker possibility of developing MTM, even in cases with preretinal traction, 6 suggesting that posterior staphyloma may play a vital role in the pathogenesis of MTM. However, all these issues were centered on high myopia.…”

Natural course of myopic traction maculopathy and factors influencing progression and visual acuity

“…Retinoschisis can occur in the fovea and extrafovea and in different locations of the intraretinal neural layers due to different dominant pathological factors. However, the mechanism of retinoschisis has not yet been fully elucidated, and many studies have shown that inward and tangential forces produced by partial posterior vitreous detachment (PVD), an epiretinal membrane, arteriosclerosis, and a stiff internal limiting membrane (ILM) and outward traction generated by asynchronous global elongation and posterior staphyloma may play important roles in its pathogenesis [ 7 – 11 ].…”

Natural Course of Myopic Traction Maculopathy and Factors Influencing Progression and Visual Acuity

“…Retinoschisis can occur in the fovea and extrafovea and in different locations of the intraretinal neural layers due to different dominant pathological factors. However, the mechanism of retinoschisis has not yet been fully elucidated, and many studies have shown that inward and tangential forces produced by partial posterior vitreous detachment (PVD), an epiretinal membrane, arteriosclerosis, and a stiff internal limiting membrane (ILM) and outward traction generated by asynchronous global elongation and posterior staphyloma may play important roles in its pathogenesis [7][8][9][10][11] .…”