Morphological analysis of house mice, Mus musculus (Rodentia, Muridae) in Southern and Eastern Indonesia and Western Australia

Maryanto, Ibnu; Kitchener, D. J.; Prijono, Siti Nuramaliati

doi:10.3106/1348-6160(2005)30[53:maohmm]2.0.co;2

Cited by 5 publications

(4 citation statements)

References 16 publications

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“…All 5 of these species are native to south central or Southeast Asia and thus, like G. gallus, have ranges that overlap the range of M. m. castaneus (Fig. 6) (45,47). None of the 3 XPR1 mutations was found in 11 other fowl and raptor species native to the Middle East, Australia, or the Americas, areas populated largely by M. m. domesticus, or in the case of quail, by M. m. musculus and Mus musculus molossinus, which is a natural hybrid of M. m. musculus and M. m. castaneus (48).…”

Section: Discussionmentioning

confidence: 99%

The Avian XPR1 Gammaretrovirus Receptor Is under Positive Selection and Is Disabled in Bird Species in Contact with Virus-Infected Wild Mice

Martin

Buckler-White

Wollenberg

et al. 2013

J Virol

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Xenotropic mouse leukemia viruses (X-MLVs) are broadly infectious for mammals except most of the classical strains of laboratory mice. These gammaretroviruses rely on the XPR1 receptor for entry, and the unique resistance of laboratory mice is due to two mutations in different putative XPR1 extracellular loops. Cells from avian species differ in susceptibility to X-MLVs, and 2 replacement mutations in the virus-resistant chicken XPR1 (K496Q and Q579E) distinguish it from the more permissive duck and quail receptors. These substitutions align with the two mutations that disable the laboratory mouse XPR1. Mutagenesis of the chicken and duck genes confirms that residues at both sites are critical for virus entry. Among 32 avian species, the 2 disabling XPR1 mutations are found together only in the chicken, an omnivorous, ground-dwelling fowl that was domesticated in India and/or Southeast Asia, which is also where X-MLV-infected house mice evolved. The receptor-disabling mutations are also present separately in 5 additional fowl and raptor species, all of which are native to areas of Asia populated by the virus-infected subspecies Mus musculus castaneus. Phylogenetic analysis showed that the avian XPR1 gene is under positive selection at sites implicated in receptor function, suggesting a defensive role for XPR1 in the avian lineage. Contact between bird species and virus-infected mice may thus have favored selection of mouse virus-resistant receptor orthologs in the birds, and our data suggest that similar receptor-disabling mutations were fixed in mammalian and avian species exposed to similar virus challenges.T he transmission of retroviruses to new hosts can result in the emergence of new infectious diseases and can alter the host genomic architecture and gene-regulatory networks, but the factors that determine whether a pathogen can successfully infect a novel host are poorly understood (1). The xenotropic mouse leukemia viruses (X-MLVs) are gammaretroviruses originally isolated from laboratory mice that are unable to infect the cells of these mice (2). These viruses rely on the XPR1 cell surface receptor for entry (3-5), and receptor orthologs from other mammals, like humans and cats, as well as the various species of wild mice, all permit X-MLV entry (6, 7). The resistance of laboratory mouse cells to infection is due to mutations that alter two XPR1 residues, K500E in the putative third extracellular loop (ECL3) and T582⌬ in the fourth loop (ECL4) (8).There is substantial sequence variation in the receptor-determining regions of the mammalian XPR1 orthologs, and some of these receptor variants show altered ability to mediate entry of one or more of the 6 known host range variants in the XP-MLV family of xenotropic/polytropic viruses (6, 9). In addition to X-MLV, this family includes viruses first described as broadly polytropic (PMLVs) because of their ability to infect mouse cells, as well as cells of other species (10, 11). Other variants, like xenotropic murine leukemia virus-related virus (XMRV) (12) an...

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Section: Discussionmentioning

confidence: 99%

The Avian XPR1 Gammaretrovirus Receptor Is under Positive Selection and Is Disabled in Bird Species in Contact with Virus-Infected Wild Mice

Martin

Buckler-White

Wollenberg

et al. 2013

J Virol

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“…It is within these terraces that erosion and dissolution has produced shelters and caves, including Here Sorot Entapa (HSE), the subject of our excavation. Kisar today has an extremely depauperate terrestrial fauna with only a few species of bats, small rodents, small lizards, and snakes recorded (How et al 1996;Maryanto et al 2005;Monk et al 1997;Prawasti et al 2013;Zug 2010). During the course of our surveys we also identified the presence of at least one shrew species.…”

Section: Kisar Islandmentioning

confidence: 99%

Kisar and the Archaeology of Small Islands in the Wallacean Archipelago

O’Connor

Mahirta

Kealy

et al. 2018

The Journal of Island and Coastal Archaeology

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The occupation of small islands presents particular challenges for people largely related to limited terrestrial resources and susceptibility to natural disasters. Nevertheless, the challenges and risks inherent in maintaining stable populations on small islands can be offset or overcome through the use of maritime technologies and exchange networks. The archaeology of Here Sorot Entapa rockshelter (HSE) on Kisar Island in the Wallacean Archipelago provides an unparalleled record for examining these issues in Southeast Asia. Kisar is the smallest of the Wallacean islands known to have a Pleistocene occupation record, and one of the smallest permanently inhabited today. Our results indicate that Here Sorot Entapa was first occupied in the terminal Pleistocene by people with advanced maritime technology who made extensive use of local marine resources and engaged in social connections with other islands through an obsidian exchange network. As a result, populations appear to have been maintained on the island for approximately 6,000 years. In the early Holocene occupation at HSE ceased for unknown reasons, and the site was not reoccupied until the mid-Holocene, during which time a major change in the lithic resources can be observed and the exchange network appears to have ceased.

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“…Dalam studi eksperimental yang dilakukan, dipilih 30 ekor mencit DDY jantan dengan berat 20-40 g, dipelihara didalam laboratorium yang memenuhi syarat [6]. Mencit yang digunakan telah disetujui oleh Komite Etik Hewan, Fakultas Kedokteran, Universitas Mulawarman (No.91/KEPK-FK/VI/2019).…”

Section: Hewan Ujiunclassified

Interaksi Metformin dan Perasan Jahe Terhadap Kadar Glukosa Darah dan Organ Mencit Diabetes

Andi

Mita²,

Indriyanti³

2019

Proc. Mul. Pharm. Conf.

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Metformin dengan jahe ketika digunakan bersamaan efek antidiabetes yang dimiliki keduanya bekerja secara sinergis dalam menurunkan kadar glukosa darah. Tujuan dari penelitian ini adalah untuk melihat interaksi yang terjadi akibat penggunaan perasan jahe dan metformin yang dilihat dari perubahan kadar glukosa darah dan organ mencit diabetes. Mencit diabetes yang telah diinduksi alloksan dibagi menjadi enam kelompok dan diobati dengan metformin, perasan jahe, kombinasi perasan jahe dan metformin 1x1 dan kombinasi perasan jahe dan metformin 2x1 selama empat hari. Kadar glukosa darah di ukur sebelum dan sesudah pengobatan selama empat hari berturut-turut. Data berat badan yang didapatkan menunjukkan terjadi penurunan berat badan namun tidak signifikan (p>0,05) Nilai signifikansi perubahan kadar glukosa darah saat dianalisis menunjukkan perbedaan signifikan dengan nilai (p<0,05). Untuk, index organ hati dan lambung yang diberi perlakuan terdapat perbedaan yang signifikan dengan nilai (p<0,05). Degenerasi pada sel hepar berkurang saat diobati dengan perasan jahe, maupun kombinasi perasan jahe dengan metformin. Penggunaan jahe dengan metformin sekali sehari dapat menurunkan kadar glukosa darah tanpa menimbulkan resiko hipoglikemik dan degenerasi sel hepar.

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Morphological analysis of house mice, Mus musculus (Rodentia, Muridae) in Southern and Eastern Indonesia and Western Australia

Cited by 5 publications

References 16 publications

The Avian XPR1 Gammaretrovirus Receptor Is under Positive Selection and Is Disabled in Bird Species in Contact with Virus-Infected Wild Mice

The Avian XPR1 Gammaretrovirus Receptor Is under Positive Selection and Is Disabled in Bird Species in Contact with Virus-Infected Wild Mice

Kisar and the Archaeology of Small Islands in the Wallacean Archipelago

Interaksi Metformin dan Perasan Jahe Terhadap Kadar Glukosa Darah dan Organ Mencit Diabetes

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