Morphological and Ancillary Features of Uterine Leiomyosarcoma: Case Report

Boşoteanu, Mădălina; Vodă, Raluca Ioana; Aşchie, Mariana; Boșoteanu, Luana-Andreea; Bălțătescu, Gabriela Izabela

doi:10.1177/2632010x221105224

Cited by 6 publications

(6 citation statements)

References 19 publications

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“…There have been numerous case reports on leiomyosarcoma of the uterus in recent years. The vast majority of these case reports deal with unusual clinical characteristics of the tumor ( 66 ), uncommon distant metastases ( 67 ), treatment outcomes ( 68 ), etc. Upon reviewing these case reports, one discovers that the majority of them are case studies, making it impossible to categorize and condense uLMS.…”

Section: Discussionmentioning

confidence: 99%

A bibliometric analysis of literatures on uterine leiomyosarcoma in the last 20 years

Huang,

Chen,

et al. 2024

Front. Oncol.

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BackgroundUterine leiomyosarcoma(uLMS) is a rare malignant tumor with low clinical specificity and poor prognosis.There are many studies related to uLMS, however, there is still a lack of metrological analyses with generalization. This study provides a bibliometric study of uLMS.Methods and materialsWe chose the Web of Science (WoS) as our main database due to its extensive interdisciplinary coverage. We specifically focused on the literature from the last 20 years to ensure relevance and practicality. By utilizing the WOS core dataset and leveraging the R package “bibliometric version 4.1.0” and Citespace, we performed a comprehensive bibliometric analysis. This allowed us to pinpoint research hotspots and create visual representations, resulting in the retrieval of 2489 pertinent articles.ResultsThis literature review covers 2489 articles on uterine leiomyosarcoma (uLMS) from the past 20 years. Key findings include an average annual publication rate of 8.75, with a 6.07% yearly growth rate and an average citation count of 17.22. Core+Zone 2 sources contributed 1079 articles and 207 reviews, displaying a 4.98% annual growth rate. The analysis identified top journals, influential authors, and core sources, such as the prevalence of publications from the United States and the dominance of GYNECOLOGIC ONCOLOGY and HENSLEY ML. Bradford’s Law and Lotka’s Law highlighted core sources and author productivity, respectively. Thematic mapping and factorial analysis revealed research clusters, including etiology, diagnosis, treatment advancements, and surgical approaches, with prominent themes such as gemcitabine and docetaxel. Overall, this comprehensive analysis provides insights into uLMS literature trends and influential factors.ConclusionThis thorough bibliometric analysis, in its whole, illuminates the field’s guiding principles while also revealing the subtle patterns within the uLMS literature. The knowledge gained here contributes to the current discussion in uLMS and related scientific fields and provides a solid basis for future research paths.

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Section: Discussionmentioning

confidence: 99%

A bibliometric analysis of literatures on uterine leiomyosarcoma in the last 20 years

Huang,

Chen,

et al. 2024

Front. Oncol.

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“…Currently, the treatment of leiomyosarcoma still primarily involves surgical excision [17], removing the tumor visible to the naked eye, ensuring that the margins are pathologically negative intraoperatively, and then expanding the excision to include more than 2 cm of normal tissue [18]. Late-stage tumors have a higher degree of malignancy, with a short disease-free survival period, typically between 6 to 24 months [19], and surgery is di cult to achieve complete removal, so radiotherapy may be added before or after surgery [20]. Studies have shown that bevacizumab can effectively treat certain soft tissue sarcomas [21], but there is a lack of clinical data to support this for primary intracranial-extracranial communicating leiomyosarcomas.…”

Section: Discussionmentioning

confidence: 99%

Surgical treatment of primary intracranial and extracranial communicating leiomyosarcoma: a case report

Pu,

Wang,

et al. 2024

Preprint

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Background: Primary intracranial-extracranial communicating leiomyosarcomas, capable of invading both the intracranial and extracranial regions and involving complex anatomical structures, are exceedingly rare neoplasms. Case presentation: A 37-year-old male patient who initially presented with a subcutaneous mass on the left frontal vertex. Following surgical intervention, a recurrent lump appeared on the left frontotemporal vertex. Symptoms, computed tomography (CT), and magnetic resonance imaging (MRI) revealed a lump on the left frontal vertex accompanied by an irregular abnormal lesion. On both occasions, the diagnosis of leiomyosarcoma was confirmed. The patient underwent leiomyosarcoma excision under general anesthesia. Recurrence of the leiomyosarcoma occurred 2 years and 4 months post-surgery, necessitating an expanded excision of the lesion. After 2 years of follow-up, no significant complications were observed, and the patient's condition remains stable. Conclusion: Primary extracranial communicating leiomyosarcoma is an exceptionally rare entity, with surgery currently serving as the primary treatment modality. The decision to excise the lesion should be based on the patient’s age, tumor location, pathological features, and the presence of distant metastases.

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“…Our case was visualized with well-defined margins but a heterogeneous pattern and was therefore regarded as atypical and confusing between the aforementioned entities. However, both leiomyomas and leiomyosarcomas rarely manifest as massive abdominal ascites [ 14 , 15 ]. This is usually correlated with massive uterine enlargement exceeding 20 cm in the maximum dimension [ 14 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, both leiomyomas and leiomyosarcomas rarely manifest as massive abdominal ascites [ 14 , 15 ]. This is usually correlated with massive uterine enlargement exceeding 20 cm in the maximum dimension [ 14 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

Flares of Confusion: A Case Report of Uterine Leiomyoma and Angiomatosis Complexity on Imaging

Al-Ibraheem,

Abdulrahman,

Abdlkadir

et al. 2023

Cureus

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Over the past decade, a series of rare and extraordinary uterine tumors have been discovered, with some featuring exceptionally uncommon tumor types. This highlights the growing recognition of these rare tumors due to evolutionary radiologic advancements. However, evaluating these patients requires adequate understanding to avoid misinterpretation and potential confusion with alternative differential diagnoses. This case is the first documented instance of two coexistent uterine benign tumors in a 45-year-old unmarried female patient. The patient's medical, gynecological, and surgical histories were unremarkable. Conventional abdominopelvic imaging via computed tomography (CT) and magnetic resonance imaging (MRI) revealed significant uterine expansion, indicating an atypical leiomyomatous or potentially leiomyosarcomatous mass. Subsequently, [ 18 F]fluorodeoxyglucose ([ 18 F]FDG) positron emission tomography (PET)/CT revealed hypermetabolic uterine enlargement, suggesting further evaluation. The patient underwent radical hysterectomy, and histopathological analysis revealed multiple uterine fibroids concurrently existing against the uterine angiomatosis. This case is the first documented instance of intricate pathological interplay within the uterus.

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Morphological and Ancillary Features of Uterine Leiomyosarcoma: Case Report

Cited by 6 publications

References 19 publications

A bibliometric analysis of literatures on uterine leiomyosarcoma in the last 20 years

A bibliometric analysis of literatures on uterine leiomyosarcoma in the last 20 years

Surgical treatment of primary intracranial and extracranial communicating leiomyosarcoma: a case report

Flares of Confusion: A Case Report of Uterine Leiomyoma and Angiomatosis Complexity on Imaging

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