2010
DOI: 10.1007/s10565-010-9155-5
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Morphological and biochemical changes during formocresol induced cell death in murine peritoneal macrophages: apoptotic and necrotic features

Abstract: The present study was conducted to investigate the role of Formocresol (FC)-induced apoptosis and necrotic cell death in murine peritoneal macrophages (pMø). Macrophages were cultured with 1:100 FC for 2 to 24 h. The viability (trypan blue assay), cell morphology (scanning electronic microscope), and apoptotic and necrotic indexes (light and fluorescent microscopy) were determined at different scheduled times. Simultaneously, the expressions of proteins related to stress, survival, and cell death were measured… Show more

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Cited by 2 publications
(5 citation statements)
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“…), and formocresol induces apoptosis and necrosis in murine peritoneal macrophages (Cardoso et al . ). Additionally, while generally accepted as a direct cause of nasopharyngeal cancer, formaldehyde has also been strongly associated with leukaemia (Zhang et al .…”
Section: Discussionmentioning
confidence: 97%
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“…), and formocresol induces apoptosis and necrosis in murine peritoneal macrophages (Cardoso et al . ). Additionally, while generally accepted as a direct cause of nasopharyngeal cancer, formaldehyde has also been strongly associated with leukaemia (Zhang et al .…”
Section: Discussionmentioning
confidence: 97%
“…, Cardoso et al . , Lewis ). Formocresol has been shown to cause DNA damage in mouse bone marrow (Ramos et al .…”
Section: Discussionmentioning
confidence: 99%
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