1997
DOI: 10.1016/s0142-9612(96)00133-0
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Morphological and biomechanical difference in healing in segmental tibial defects implanted with Biocoral® or tricalcium phosphate cylinders

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Cited by 57 publications
(32 citation statements)
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“…Both cortical and spongy bone defects were at least partially filled with new bone after 8 weeks, while the implants underwent continuous resorption. In a previous study [10], we compared biocoral and tricalciumphosphate (TCP) in sheep tibial defects, and the conclusion was that coral seemed to be superior to TCP in repairing of segmental defects in weight-bearing limbs. The capacity of native BMPs to induce bone formation and heal bone defects has been studied in various animal models with favorable results in most cases [9,13,21,23].…”
Section: Discussionmentioning
confidence: 99%
“…Both cortical and spongy bone defects were at least partially filled with new bone after 8 weeks, while the implants underwent continuous resorption. In a previous study [10], we compared biocoral and tricalciumphosphate (TCP) in sheep tibial defects, and the conclusion was that coral seemed to be superior to TCP in repairing of segmental defects in weight-bearing limbs. The capacity of native BMPs to induce bone formation and heal bone defects has been studied in various animal models with favorable results in most cases [9,13,21,23].…”
Section: Discussionmentioning
confidence: 99%
“…When implanted into bone tissue, the open pore structure allows formation of a fibrovascular tissue throughout the implant progressively replaced by bone. 15,16 Bioabsorbable calcium carbonate implants from the genus Porites appear well tolerated and have been shown to support bone regeneration in a variety of settings including posterolateral lumbar spinal fusion, 17 repair of long bone defects, 18,19 alveolar augmentation, 20 and periodontal regeneration. [21][22][23] Space provision was significantly enhanced following use of the coral implant.…”
Section: Representative Photomicrographs Of Defect Sites Receiving Thmentioning
confidence: 99%
“…Different animal species have also been used to evaluate bone substitutes. For instance, in vivo studies have been conducted in rats, 10,15,20 rabbits, 8,16,[21][22][23][24][25] dogs, 13,26,27 sheep, 9 and goats. 28 As these animals are different in terms of their metabolisms and bone physiology, direct and strict comparison between all these studies is difficult.…”
Section: Introductionmentioning
confidence: 99%