Morphological and clinical picture of the morphea in the oral cavity

Pedowska, Marlena; Ptasiewicz, Maja; Szumiło, Justyna; Chałas, Renata

doi:10.5603/fm.a2021.0083

Cited by 2 publications

(2 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Antimalarial drugs such as chloroquine have also been favoured with less side effect profile, along with topical, oral and injectable corticosteroids. 13 Narrow-band ultraviolent can also be used to treat morphea. Because of some similarities in this group of conditions, medications used in treatment of other forms of morphea and scleroderma are commonly used to treat en coup de sabre morphea and Parry-Romberg syndrome.…”

Section: Treatmentmentioning

confidence: 99%

“…Because of some similarities in this group of conditions, medications used in treatment of other forms of morphea and scleroderma are commonly used to treat en coup de sabre morphea and Parry-Romberg syndrome. 13,14 Prognosis and conclusions Localized forms of morphea commonly tend to burn-out even in the absence of active treatment, leaving permanent scarring, pigmentary changes with or without disfiguration of the underlying structures. Treatment is however highly recommended to halt the progression of the disease.…”

Section: Treatmentmentioning

confidence: 99%

See 1 more Smart Citation

<em>En coup de sabre</em> morphea: An uncommon condition in Africa

et al. 2022

View full text Add to dashboard Cite

The term en coup de sabre morphea refers to a lesion of linear morphea typically located in the frontoparietal scalp and/or the paramedian forehead, often resembling a strike with a sword. In literature, en coup de sabre morphea and en coup de sabre scleroderma are terms used interchangeably and synonymously. Due to the rarity of this condition, treatment is largely based on case report series, leaving much room for speculation in terms of drugs of choice, duration of treatment and dosages. Although typically leaving behind notable and often permanent skin pigmentary changes and indentation of the affected areas, this condition usually remits spontaneously, even in the absence of active form of treatment. The disease severity and prognosis vary according to the subtype: circumscribed morphea has a generally more benign course when compared with linear scleroderma and generalised morphea.

show abstract

Section: Treatmentmentioning

confidence: 99%

Section: Treatmentmentioning

confidence: 99%

<em>En coup de sabre</em> morphea: An uncommon condition in Africa

et al. 2022

View full text Add to dashboard Cite

show abstract

What Is New in Morphea—Narrative Review on Molecular Aspects and New Targeted Therapies

Stein,

Cieplewicz-Guźla,

Iżykowska

et al. 2024

JCM

View full text Add to dashboard Cite

Morphea, also known as localized scleroderma, is an autoimmune chronic connective tissue disease. It is characterized by excessive collagen deposition in the dermis and/or subcutaneous tissue. The etiopathogenesis of this disease is not fully understood, with endothelial cell damage, immunological disorders, extracellular matrix disorders and factors such as infection, trauma and other autoimmune diseases being considered. As medicine advances, there is increasing evidence that genetic factors play a significant role in disease risk and progression. In addition to environmental factors and genetic predisposition, epigenetic factors may be potential triggers for morphea. Epigenetics studies changes that affect gene expression without altering the DNA sequence, such as microRNAs, long non-coding RNAs or DNA methylation. Understanding the pathogenesis of this disease is key to identifying potential new treatments. There are anecdotal reports of good therapeutic effects following the use of biological drugs such as tocilizumab, a humanized IgG monoclonal antibody; abatacept, a recombinant soluble fusion protein; JAK inhibitors, such as tofacitinib and baricitinib; and a drug used successfully in cancer treatment, imatinib, a tyrosine kinase receptor inhibitor. In this article, we aim to review up-to-date knowledge on the pathogenesis of morphea, with particular emphasis on genetic and epigenetic factors. In addition, we present the new options of morphea treatment based on several case series treated with new drugs that are potential targets for the development of therapies for this disease.

show abstract

Morphological and clinical picture of the morphea in the oral cavity

Abstract: This article has been peer reviewed and published immediately upon acceptance.It is an open access article, which means that it can be downloaded, printed, and distributed freely, provided the work is properly cited. Articles in "Folia Morphologica" are listed in PubMed.

Cited by 2 publications

References 18 publications

<em>En coup de sabre</em> morphea: An uncommon condition in Africa

<em>En coup de sabre</em> morphea: An uncommon condition in Africa

What Is New in Morphea—Narrative Review on Molecular Aspects and New Targeted Therapies

Contact Info

Product

Resources

About