Morphological and Compositional Analysis of Neutrophil Extracellular Traps Induced by Microbial and Chemical Stimuli

Almaraz-Arreortua, Alexia; Sosa-Luis, Sorely Adelina; Ríos-Ríos, William de Jesús; Romero-Tlalolini, María de los Ángeles; Aguilar-Ruiz, Sergio Roberto; Baltiérrez-Hoyos, Rafael; Aguilar, Honorio Torres

doi:10.3791/64522

Cited by 2 publications

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“… 10 Neutrophils derived from the myeloid progenitor cells are differentiated and recruited to sites of inflammation after certain triggers. 11 The granules of neutrophils are classified into primary, secondary, and tertiary granules, consisting of myeloperoxidase, defensins, proteinase 3, collagenase, gelatinase, lactoferrin, and sialidase. 12 Neutrophils phagocytose, release granular contents and produce the reactive oxygen species (ROS) to eliminate pathogenic agents.…”

Section: Lipid Metabolism Reprogramming Of Immune Cells In Acnementioning

confidence: 99%

Lipid Metabolism Reprogramming of Immune Cells in Acne: An Update

Wu,

Zhang,

Wang

et al. 2023

CCID

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Acne vulgaris is one of the most widespread skin conditions and the main reason for visiting a dermatologist. Inflammatory response and abnormal infiltrations of immune cells are the main pathogenesis of acne. The increased lipid is the prerequisite for the acne, and the perturbation of lipid composition and content is consistent with the severity of acne. Furthermore, the increased lipid production not only contributes to the occurrence and development of acne, but also sensitizes the function of immune cells. The lipid metabolic dysfunction aggravates the severity of local tissue and provides pro-inflammatory-cytokine cues, which indicates the crucial roles of lipid metabolism on immune cells. Recent advances have demonstrated the lipid metabolism reprogramming of various immune cells in acne lesion. The abnormal lipid accumulation, lipolysis, and fatty acid oxidation lead to the activation and differentiation of immune cells, which promotes the pro-inflammatory cytokines production. Thus, this review discusses the emerging role of lipid metabolism reprogramming of immune cells in the progress of acne and aims to constitute food for others’ projects involved in acne research.

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Section: Lipid Metabolism Reprogramming Of Immune Cells In Acnementioning

confidence: 99%

Lipid Metabolism Reprogramming of Immune Cells in Acne: An Update

Wu,

Zhang,

Wang

et al. 2023

CCID

View full text Add to dashboard Cite

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Helicobacter pylori extract induces purified neutrophils to produce reactive oxygen species only in the presence of plasma

Thai,

Chuenchom,

Donsa

et al. 2023

Biomed Rep

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H. pylori is a bacterial pathogen infecting over half of the world's population and induces several gastric and extra-gastric diseases through its various virulence factors, especially cagA. These factors may be released from the bacteria during interactions with host immune cells. Neutrophils play key roles in innate immunity, and their activity is regulated by plasma factors, which can alter how these cells may interact with pathogens. The aim of the present study was to determine whether purified neutrophils could produce reactive oxygen species (ROS), one of the key functions of their anti-microbial functions, in response to extracts of cagA+ and cagA-H. pylori. Extracts from either cagA+ or cagA-H. pylori were co-cultured with human neutrophils in the presence or absence of plasma, and the neutrophil ROS production was measured. In the absence of plasma, extracts from cagA+ and cagA-H. pylori did not induce neutrophil ROS production, whereas in the presence of plasma, extracts from both cagA+ and cagA-H. pylori-induced ROS production. Furthermore, when peripheral blood mononuclear cells (PBMCs) were added to the purified neutrophils in the absence of plasma, there was no neutrophil ROS production after challenging with extracts from either cagA+ or cagA-H. pylori. Thus, it is suggested that plasma contains immunological components that change the responsiveness of neutrophils, such that when neutrophils encounter the bacterial antigens in H. pylori extracts, they become activated and produce ROS. This study also revealed a potential novel immunopathogenic pathway by which cagA activation of neutrophils contributed to inflammatory damage.

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Morphological and Compositional Analysis of Neutrophil Extracellular Traps Induced by Microbial and Chemical Stimuli

Cited by 2 publications

References 0 publications

Lipid Metabolism Reprogramming of Immune Cells in Acne: An Update

Lipid Metabolism Reprogramming of Immune Cells in Acne: An Update

Helicobacter pylori extract induces purified neutrophils to produce reactive oxygen species only in the presence of plasma

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