Morphological and demographic associations of biliary symptoms in subjects with gallstones: findings from a population-based survey in Rosario, Argentina

A, Brasca; Berli, D.; Pezzotto, Stella Maris; Gianguzzo, Maria P.; Villavicencio, R; Fray, O.; Poletto, Leonor

doi:10.1016/s1590-8658(02)80091-3

Cited by 6 publications

(18 citation statements)

References 28 publications

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“…The association between gallstone age and outcome has not been previously studied. We found no association between stone mobility and gallstone events, which is in accordance with previous crosssectional screening studies 30,31 .…”

Section: A C C E P T E D Accepted Manuscriptsupporting

confidence: 93%

“…In addition, participant age was inversely associated with gallstone events (Table 4). When participant age was split into decades, the youngest (30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40) and 40-50 years of age) participants were significantly associated with gallstone events when compared to the oldest (60-70 years of age) in an unadjusted model (data not shown). Gallstone age less than or equal to five years or the co-morbidities of diabetes and hypertension had no associations with all events.…”

Section: All Eventsmentioning

confidence: 99%

“…No previous cohort studies have found this association 6,9 . Previous cross-sectional screening studies have found no association between stone size or multiplicity of stones with abdominal symptoms [29][30][31] .…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

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A Prediction Rule for Risk Stratification of Incidentally Discovered Gallstones: Results From a Large Cohort Study

2016

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Section: A C C E P T E D Accepted Manuscriptsupporting

confidence: 93%

Section: All Eventsmentioning

confidence: 99%

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A Prediction Rule for Risk Stratification of Incidentally Discovered Gallstones: Results From a Large Cohort Study

2016

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“…1,2 Gallstones occur twice as common in females as in males, with the prevalence peaking in the sixth and seventh decade. 3,4 Interestingly, several cultural and ethnic groups demonstrate an extremely high incidence of gallstones compared to other populations. In most of the series, 70-80% of patients undergo elective cholecystectomy for chronic cholecystitis or biliary colic in conjunction with ultrasonography evidence of gallstones.…”

Section: Discussionmentioning

confidence: 99%

“…The symptomatic biliary stone disease may progress to complications such as acute cholecystitis, choledocholithiasis with or without cholangitis, gallstone pancreatitis, cholecysto-choledochal fistula, cholecystoenteric fistula leading to gallstone ileus. 3 Diagnostic methods for the imaging diagnosis of Biliary stone disease have been proliferating rapidly in recent years and the choice can be bewildering. 4 Cholecystectomy is the treatment of choice for symptomatic gallstones because it removes the organ that contributes to both the formation of gallstones and the complications ensuing from them.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological study and management of biliary stones

Dasari

Dandinarasaiah

Harwal³

et al. 2018

Int Surg J

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Background: Biliary calculi are one of the most common problems affecting the digestive tract. Need for the study is to evaluate age, sex, incidence, most common etiopathological factors for the formation of biliary calculi and to illustrate varying clinical presentation with various modes of management adopted in the institution as well as to analyse biochemical types of stones prevalent in the region.Methods: A prospective study of 50 patients with clinical diagnosis of biliary colic was conducted in a tertiary center for a period of one year. Clinical presentation, etiology, and management of biliary calculi were studied.Results: Biliary calculi affect most commonly in fourth to the fifth decade with a higher preponderance in females (72%). Right hypochondriac pain is the commonest presentation (84%). Ultrasonography is sensitive and specific, and hence considered the investigation of choice. Open surgical procedures such as cholecystectomy, choledochotomy with T-tube drainage, choledochoduodenostomy were done in these subjects. Postoperative complications such as wound infection noted in 8% of the subjects. Most of the histopathological specimens (90%) revealed chronic cholecystitis.Conclusions: Biliary calculus disease is multifactorial in origin with slight female preponderance. The most common presentation is a right hypochondriac pain. This can be diagnosed accurately with the aid of ultrasonography and Endoscopic Retrograde Cholangio-pancreatography. Biliary calculus is managed according to the location of the calculus, whether intrahepatic or extrahepatic. Most of the patients presented with chronic cholecystitis.

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Μείζονες Κακώσεις Χοληφόρων Κατά Τη Διάρκεια Λαπαροσκοπικής Χολοκυστεκτομής Που Οδηγούν Σε Μεταμόσχευση Ήπατος

Τσαπάρας¹

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Εισαγωγή: Η μεταμόσχευση ήπατος έχει χρησιμοποιηθεί ως έσχατη λύση σε ασθενείς με ηπατική νόσο τελικού σταδίου λόγω μη διαχειρίσιμων τραυμάτων του χοληφόρου δέντρου μετά από χολοκυστεκτομή. Η παρούσα μελέτη στοχεύει στον εντοπισμό και την αξιολόγηση παραγόντων που προκαλούν ή συμβάλλουν σε μια εκτεταμένη ηπατική νόσο που απαιτεί μεταμόσχευση ήπατος ως τελική θεραπεία. Μέθοδοι: Ασθενείς που πληρούσαν τα κριτήρια μιας ευρύτατης βάσης δεδομένων που συνετάχθη, συλλέχθηκαν προοπτικά από 8 διεθνή μεταμοσχευτικά κέντρα και αναλύθηκαν αναδρομικά. Αποτελέσματα: Τριάντα τέσσερις ασθενείς (16 άνδρες, 18 γυναίκες) με μέση ηλικία 45 ετών (εύρος 22-69) ετών συμπεριλήφθηκαν σε αυτή τη μελέτη. Τριάντα από αυτούς (88.2%) υποβλήθηκαν σε μεταμόσχευση λόγω ηπατικής ανεπάρκειας, ως αποτέλεσμα δευτερογενούς χολικής κίρρωσης. Το διάμεσο χρονικό διάστημα μεταξύ κάκωσης χοληφόρων και μεταμόσχευσης ήπατος ήταν 63μήνες. Υπήρξαν 23 περιπτώσεις (67.6%) μετεγχειρητικής νοσηρότητας, 6 περιπτώσεις (17.6%) θνησιμότητας 30 ημερών μετά την επέμβαση και 10 θανάτων (29.4%) συνολικά . Η συνολική επιβίωση μετά τη μεταμόσχευση ήπατος στα 1-, 3-, 5- και 10-έτη ήταν 82.4%, 76.5%, 73.5% και 70.6%, αντίστοιχα. Ασθενείς που υποβλήθηκαν σε μεταμόσχευση ήπατος σε χρονικό διάστημα μεγαλύτερο των 2 ετών μετά την αναγνώριση της κάκωσης εμφάνισαν περισσότερες μετεγχειρητικές επιπλοκές Υπήρχε μεγαλύτερη πιθανότητα για ασθενείς με ταυτόχρονο αγγειακό τραυματισμό (HR: 10.69, p = 0.039) να καταλήξουν νωρίτερα σε μεταμόσχευση ήπατος όπως και για εκείνους που είχαν υποβληθεί σε λαπαροσκοπική χολοκυστεκτομή παρά σε ανοιχτή. Συμπεράσματα: Η μεταμόσχευση σε επιλεγμένους ασθενείς με κατά τα άλλα μη διαχειρίσιμη κάκωση χοληφόρων μετά από χολοκυστεκτομή παρέχει αποδεκτά μακροπρόθεσμα αποτελέσματα.

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Morphological and demographic associations of biliary symptoms in subjects with gallstones: findings from a population-based survey in Rosario, Argentina

Cited by 6 publications

References 28 publications

A Prediction Rule for Risk Stratification of Incidentally Discovered Gallstones: Results From a Large Cohort Study

A Prediction Rule for Risk Stratification of Incidentally Discovered Gallstones: Results From a Large Cohort Study

Clinicopathological study and management of biliary stones

Μείζονες Κακώσεις Χοληφόρων Κατά Τη Διάρκεια Λαπαροσκοπικής Χολοκυστεκτομής Που Οδηγούν Σε Μεταμόσχευση Ήπατος

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