Morphological and electrophysiological properties of ACCx nociceptive neurons in rats

Yamamura, Hozumi

doi:10.1016/s0006-8993(96)00561-6

Cited by 42 publications

(42 citation statements)

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“…Noci-responsive neurons in the rat are found in more rostral ACC areas that include both rostral area 24b and dorsal area 32 (14). These electrophysiological findings are supported by anatomical studies demonstrating projections of medial and intralaminar thalamic nuclei to the ACC.…”

Section: Discussionmentioning

confidence: 53%

“…Electrophysiological studies lend support to this view of ACC processing. First, neurons in the ACC respond both to noxious stimuli and cues that predict a noxious stimulus (8,13,14,(38)(39)(40). Interestingly, one study examined response properties of individual ACC neurons to both a pain-predictive cue and a noxious stimulus (39).…”

Section: Discussionmentioning

confidence: 99%

“…Intra-ACC microinjection of ibotenic acid produced lesions with clearly definable borders of neuronal cell loss and gliosis as compared with intra-ACC microinjection of PBS. Based on past studies (14,27,28), areas of the rodent ACC rich in nociceptive input were targeted. For lesion criterion analyses, rostral ACC corresponded to perigenual Brodmann's areas 24b, portions of perigenual 24a, and caudodorsal area 32 as defined by Vogt and Peters (29) and corresponded to the following coordinates (23) from bregma, the lambda-bregma plane and midline, respectively: AP, ϩ3.2 to ϩ2.2; DV, Ϫ1.0 to Ϫ3.2; ML, 0.0 Ϯ 1.4.…”

Section: Conditioning Days (Days 2-5)mentioning

confidence: 99%

“…A selective reduction in F-CPA was hypothesized. Importantly, the rodent ACC has been divided into a perigenual region that preferentially receives nociceptive input (14,27,28) and a postgenual region that receives comparatively little nociceptive input. For the purposes of this study, we named these regions the rostral ACC and the caudal ACC, respectively (see Materials and Methods for more details).…”

Section: Histologymentioning

confidence: 99%

“…In the rabbit and rat, neurons within Brodmann's area 24b of the ACC have been characterized as noci-responsive (13,14). These cells have large or whole-body receptive fields and bilateral nociceptor innervation-properties that are not inconsistent with a role in affective processing.…”

mentioning

confidence: 99%

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The affective component of pain in rodents: Direct evidence for a contribution of the anterior cingulate cortex

Johansen

Fields²,

Manning³

2001

Proc. Natl. Acad. Sci. U.S.A.

589

459

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Section: Discussionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Section: Conditioning Days (Days 2-5)mentioning

confidence: 99%

Section: Histologymentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

The affective component of pain in rodents: Direct evidence for a contribution of the anterior cingulate cortex

Johansen

Fields²,

Manning³

2001

Proc. Natl. Acad. Sci. U.S.A.

589

459

View full text Add to dashboard Cite

Cortical modulation of pain

Ohara

Vit

Jasmin

2005

CMLS, Cell. Mol. Life Sci.

122

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The sensation commonly referred to as 'pain' has two components. The first is the sensory-discriminative component and provides information on location, modality and intensity of stimuli. The second is the affective-motivational component and refers to the emotional responses (fear, distress etc.) and the urge to respond evoked by the somatic sensation, and at the cortical level these two components appear to be located in different regions. The cortex probably influences pain by two different mechanisms. There is good evidence that the cortex can reduce pain by interrupting the transmission of noxious information from the spinal cord level by activating descending pain modulatory systems located in the brainstem. Less well established is the idea that modulation can also occur at the cortical level to change the affective-motivational aspects of nociception so that pain is perceived but looses its emotional and aversive component.

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Spatial and temporal plasticity of synaptic organization in anterior cingulate cortex following peripheral inflammatory pain: multi-electrode array recordings in rats

Wang

Zhang

et al. 2013

Neurosci. Bull.

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To explore whether experiencing inflammatory pain has an impact upon intracortical synaptic organization, the planar multi-electrode array (MEA) technique and 2-dimensional current source density (2D-CSD) imaging were used in slice preparations of the anterior cingulate cortex (ACC) from rats. Synaptic activity across different layers of the ACC was evoked by deep layer stimulation through one electrode. The layer-localization of both local field potentials (LFPs) and the spread of current sink calculated by 2D-CSD analysis was characterized pharmacologically. Moreover, the induction of long-term potentiation (LTP) and changes in LTP magnitude were also evaluated. We found that under naïve conditions, the current sink was initially generated in layer VI, then spread to layer V and fi nally confi ned to layers II-III. This spatial pattern of current sink movement typically reflected changes in depolarized sites from deep layers (V-VI) to superficial layers (II-III) where intra-and extracortical inputs terminate. In the ACC slices from rats in an infl amed state (for 2 h) caused by intraplantar bee-venom injection, the spatial profi le of intra-ACC synaptic organization was significantly changed, showing an enlarged current sink distribution and a leftward shift of the stimulus-response curves relative to the naïve and saline controls. The change was more distinct in the superficial layers (II-III) than in the deep site. In terms of temporal properties, the rate of LTP induction was significantly increased in layers II-III by inflammatory pain. However, the magnitude of LTP was not signifi cantly enhanced by this treatment. Taken together, these results show that infl ammatory pain results in distinct spatial and temporal plasticity of synaptic organization in the ACC, which may lead to altered synaptic transmission and modulation.

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Morphological and electrophysiological properties of ACCx nociceptive neurons in rats

Cited by 42 publications

References 0 publications

The affective component of pain in rodents: Direct evidence for a contribution of the anterior cingulate cortex

The affective component of pain in rodents: Direct evidence for a contribution of the anterior cingulate cortex

Cortical modulation of pain

Spatial and temporal plasticity of synaptic organization in anterior cingulate cortex following peripheral inflammatory pain: multi-electrode array recordings in rats

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