Morphological and functional evaluation of distal esophagus of rabbits submitted to esophageal infusion with caustic soda

Henry, Maria Aparecida Coelho de Arruda; Pelissari, Carlos Eduardo Brossi; Carvalho, Lídia Raquel de

doi:10.1590/s0102-86502008000100004

Cited by 4 publications

(3 citation statements)

References 16 publications

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“…Our observations also indicate that the vagally stimulated LES relaxation is mediated through axial stretch on the LES exerted by the longitudinal muscle contraction of the esophagus. (6), rabbit (19,22), and opossum (12,17)] to study the LES. For several reasons, opossum has been used most extensively because the LES and distal esophagus in the opossums, similar to humans, consist of smooth muscle.…”

Section: Discussionmentioning

confidence: 99%

Mechanism of stretch-activated excitatory and inhibitory responses in the lower esophageal sphincter

Jiang¹,

Bhargava²,

Mittal³

2009

American Journal of Physiology-Gastrointestinal and Liver Physi

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We recently found that an orally directed stretch of the esophagus activates a neurally mediated relaxation of the lower esophageal sphincter (LES). Goals of our study were to characterize the neural mechanisms responsible for axial and transverse stretch-activated responses in the LES. LES pressure was monitored in anesthetized and artificially ventilated mice. Sutures were placed in the esophagus to exert graded stretch in the longitudinal and transverse directions. Effects of bilateral vagotomy and pharmacological agents on the stretch-activated LES responses were investigated. The relationship between vagally stimulated axial stretch and LES relaxation was also studied. Stretch in the longitudinal and transverse directions caused a dose-dependent LES relaxation and contraction, respectively, that were not affected by bilateral vagotomy and sympathectomy but were blocked by tetrodotoxin. In bilateral vagotomized animals, hexamethonium, atropine, pyridoxalphosphate-6-azophenyl-2',4' disulfonic acid (PPADS), and ondansetron did not block the stretch-activated LES relaxation and contraction. Axial stretch-activated LES relaxation was blocked by nitric oxide inhibitor and transverse stretch-activated LES contraction was blocked by a combination of atropine and substance P antagonist. Electrical stimulation of the vagus nerve induced LES relaxation and axial stretch on the LES, both of which were blocked by rocuronium. Axial and transverse stretch-activated LES relaxation and contraction were present in the W/W(v) mice that lack interstitial cells of Cajal (ICC). Stretch-activated LES relaxation and contraction are mediated through mechanosensitive neurons located in the myenteric plexus, which involves neither synaptic transmission nor ICC.

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Section: Discussionmentioning

confidence: 99%

Mechanism of stretch-activated excitatory and inhibitory responses in the lower esophageal sphincter

Jiang¹,

Bhargava²,

Mittal³

2009

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…For instance, Bakan et al [13] have reported tissue damage in the rat esophageal samples that have gradually increased at 4, 24, 48, and 72 h after application of 10% NaOH. In another experimental study performed in rabbits, it has been demonstrated that esophageal infusion with 6% NaOH caused intense and diffuse lesions, with ulcers and large areas of necrosis, more serious at 6 and 24 h after infusion [14].…”

Section: Discussionmentioning

confidence: 97%

The diagnostic utility of scintigraphy in esophageal burn: a rat model

Çiftçi

Gül

Açıksarı

et al. 2016

Journal of Surgical Research

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“…La sévérité des lésions produites par les substances caustiques sur le tissu dépend du type, de la quantité et de la concentration de la substance caustique ingérée [3][4][5][6][7][8] aussi bien que de la période du contact avec la muqueuse [3][4][5][6]. L'endoscopie digestive haute est le principal examen morphologique initial [9,10].…”

Section: Mots Clés Produit Caustique · Ingestion · Endoscopieunclassified

Corrélation toxique, clinique et endoscopique des lésions digestives caustiques chez l’adulte

et al. 2011

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Objectifs : La gravité d'une ingestion caustique est difficile à prédire. Le but de cette étude était d'établir une corrélation entre les caractéristiques de l'ingestion, la symptomatologie clinique et les lésions endoscopiques qui résultent d'une ingestion caustique. Patients et méthodes : Dans cette étude prospective monocentrique, tous les patients adultes pris en charge entre 2006 et 2008 pour une ingestion caustique dont les détails étaient connus ont été inclus. On a procédé à des corrélations statistiques entre les caractéristiques de l'ingestion, avec les diffé-rents symptômes cliniques qui en découlent et les résultats endoscopiques. Résultats : Trois cent quatorze cas d'ingestions caustiques ont été colligés, d'âge moyen de 28,12 (15 à 79 ans). Le caractère volontaire de l'ingestion était associé à une quantité ingérée significativement plus importante (p = 0,01). Le type acide du caustique ingéré était un facteur de risque (FDR) de survenue de dysphagie (48,8 % ; p = 0,02), d'hématémèse (61,2 % ; p < 0,0001), de péritonite (78,3 % ; p = 0,002), d'oedème laryngé (p = 0,002) et de lésions endoscopiques de stade IV. La survenue d'une dysphagie (73,7 % ; p = 0,0048), d'une hématémèse (85,2 % ; p < 0,0001), d'une détresse respiratoire (91,7 % ; p = 0,001) ou de lésions ORL (72,8 % ; p = 0,0002) étaient des facteurs prédictifs de lésions endoscopiques sévères. Un tiers des patients sans symptôme avaient, malgré tout, des lésions endoscopiques sévères. Conclusion : En cas d'ingestion caustique, la nature acide du produit et la présence d'une dysphagie, d'une hématémèse ou de brûlures ORL sont des facteurs prédisant l'existence de lésions endoscopiques sévères et doivent inciter à une prise en charge urgente des patients en réanimation. L'existence de lésions endoscopiques sévères chez un tiers des patients sans symptômes impose malgré tout la réalisation systématique d'une endoscopie rapide chez tous les patients. Pour citer cette revue : Acta Endosc. 41 (2011). Mots clés Produit caustique · Ingestion · EndoscopieAbstract Objectives: The severity of caustic ingestion is difficult to predict. The aim of this study was to establish a correlation between the characteristics of ingestion, clinical symptoms and endoscopic lesions which result from caustic ingestion. Patients and methods: In this monocentric prospective study, all adult patients treated between 2006 and 2008 for a caustic ingestion whose details were known were included. We proceeded to statistical correlations between the characteristics of ingestion and different clinical symptoms which result from this and the results of endoscopy. Results: Three hundred fourteen cases of caustic ingestion were collected, with a mean age of 28.12 years (15-79 years). A suicidal ingestion was associated with a significantly greater quantity of corrosive substance (P = 0.01). The type of caustic introduced was a risk factor for dysphagia (48.8%; P = 0.02), haematemesis (61.2%; P < 0.0001), peritonitis (78.3%; P = 0.002), laryngeal oedema (P = 0.002) and several en...

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Morphological and functional evaluation of distal esophagus of rabbits submitted to esophageal infusion with caustic soda

Cited by 4 publications

References 16 publications

Mechanism of stretch-activated excitatory and inhibitory responses in the lower esophageal sphincter

Mechanism of stretch-activated excitatory and inhibitory responses in the lower esophageal sphincter

The diagnostic utility of scintigraphy in esophageal burn: a rat model

Corrélation toxique, clinique et endoscopique des lésions digestives caustiques chez l’adulte

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