Morphological and Histochemical Changes in the Parenchyma of the Rat Parotid and Sublingual Glands with Growth and Aging

Ikeda, Rie

doi:10.1016/s1349-0079(11)80021-6

Cited by 3 publications

(1 citation statement)

References 32 publications

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“…There have been many morphological studies of major salivary glands of mammals such as humans(2, 7), mice (8,9,10), and rats (2,4,11). Some of these have investigated the microstructures using transmission electron microscopy (TEM).…”

Section: Introductionmentioning

confidence: 99%

Ultrastructure of the Salivary Glands in the Gray Short-Tailed Opossum(<i>Monodelphis domestica</i>)

et al. 2016

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The salivary glands help to keep the mouth and other parts of the digestive system moist. There have been only a few reports on the salivary glands of the marsupial gray short-tailed opossum(Monodelphis domestica). The aim of this study was to reveal the ultrastructure of the parotid and submandibular glands in the gray short-tailed opossum using transmission electron microscopy(TEM). Using TEM, the parotid glands were found to consist only of serous acinar cells. Secretory granules were highly electron dense. The submandibular glands were composed of both serous and mucous acinar cells, showing a mixture of glands. Also, the submandibular glands possessed special serous cells. Secretory granules were divided into homogeneous density type, two biphasic types and annual ring types. The properties of the granules were different in each cell type. However, some cells contained a mixture of every type of granule. It appeared that the variety of granules in the special serous cells represented stages in the cell cycle and was not a property of the cell.Striated ducts of submandibular glands consisted both of columnar epithelium with or without basal infoldings, although typical striated ducts were found in parotid glands.

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Section: Introductionmentioning

confidence: 99%

Ultrastructure of the Salivary Glands in the Gray Short-Tailed Opossum(<i>Monodelphis domestica</i>)

et al. 2016

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Methylmercury Intoxication Promotes Metallothionein Response and Cell Damage in Salivary Glands of Rats

Lima

Bittencourt

Puty

et al. 2018

Biol Trace Elem Res

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Environmental and occupational mercury exposure is considered a major public health issue. Despite being well known that MeHg exposure causes adverse effects in several physiologic functions, MeHg effects on salivary glands still not completely elucidated. Here, we investigated the cellular MeHg-induced damage in the three major salivary glands (parotid, submandibular, and sublingual) of adult rats after chronic, systemic and low doses of MeHg exposure. Rats were exposed by 0.04 mg/kg/day over 60 days. After that, animals were euthanized and all three glands were collected. We evaluated total Hg accumulation, metallothionein I/II (MT I/II), α-smooth muscle actin (α-SMA), and cytokeratin 18 (CK18) immune expression. Our results have showed that MeHg is able to disrupt gland tissue and to induce a protective mechanism by MT I/II expression. We also showed that cell MT production is not enough to protect gland tissue against cellular structural damage seen by reducing marking of cytoskeletal proteins as CK18 and α-SMA. Our data suggest that chronic MeHg exposure in low-daily doses is able to induce cellular damage in rat salivary glands.

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Oral Biosciences: The annual review 2011

Ohshima

2012

Journal of Oral Biosciences

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Morphological and Histochemical Changes in the Parenchyma of the Rat Parotid and Sublingual Glands with Growth and Aging

Cited by 3 publications

References 32 publications

Ultrastructure of the Salivary Glands in the Gray Short-Tailed Opossum(<i>Monodelphis domestica</i>)

Ultrastructure of the Salivary Glands in the Gray Short-Tailed Opossum(<i>Monodelphis domestica</i>)

Methylmercury Intoxication Promotes Metallothionein Response and Cell Damage in Salivary Glands of Rats

Oral Biosciences: The annual review 2011

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