Morphological and immunohistochemical features of neuroendocrine neoplasms in gastroenteropancreatic tract

Zivojinov, Mirjana; Panić, Željka; Ilić, Aleksandra; Sabo, Jelena Ilić; Vasilijević, Milena; Lakic, Tanja

doi:10.1016/j.ajg.2022.05.005

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Prognosis Of Small Bowel Neuroendocrine Tumours1

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2023

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“…Ki-67 and mitotic count are widely used biomarkers that are regarded as prognostic markers in patients with underlying NET. A significantly higher expression of K-67 is observed in patients with metastatic disease and advanced stage of the disease [107,108].…”

Section: Prognosis Of Small Bowel Neuroendocrine Tumoursmentioning

confidence: 99%

Small bowel neuroendocrine tumours – casting the net wide

Zammit

Sidhu

2023

Current Opinion in Gastroenterology

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Purpose of review Our aim is to provide an overview of small bowel neuroendocrine tumours (NETs), clinical presentation, diagnosis algorithm and management options. We also highlight the latest evidence on management and suggest areas for future research. Recent findings Dodecanetetraacetic acid (DOTATATE) scan can detect NETs with an improved sensitivity than when compared with an Octreotide scan. It is complimentary to small bowel endoscopy that provides mucosal views and allows the delineation of small lesions undetectable on imaging. Surgical resection is the best management modality even in metastatic disease. Prognosis can be improved with the administration of somatostatin analogues and Evarolimus as second-line therapies. Summary NETs are heterogenous tumours affecting most commonly the distal small bowel as single or multiple lesions. Their secretary behaviour can lead to symptoms, most commonly diarrhoea and weight loss. Metastases to the liver are associated with carcinoid syndrome.

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Section: Prognosis Of Small Bowel Neuroendocrine Tumoursmentioning

confidence: 99%