Morphological and immunohistological study of testicular lymphomas

Wilkins, Bridget S.; Williamson, J. M. S.; O'Brien, C J

doi:10.1111/j.1365-2559.1989.tb03062.x

Cited by 37 publications

(11 citation statements)

References 19 publications

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“…This correlation is consistent with a recent report where the expression of an IgM was associated with the worst prognosis in a large series of nodal DLBCL cases. 16 It is also consistent with the observation that this isotype predominates in rare and aggressive forms of lymphomas, such as primary central nervous system, 15 primary testicular 17 and primary cutaneous DLBCL, 18,19 which all have an ABC-like phenotype. 20 Isotype class switching in DLBCL P Ruminy et al…”

Section: Discussionsupporting

confidence: 84%

The isotype of the BCR as a surrogate for the GCB and ABC molecular subtypes in diffuse large B-cell lymphoma

et al. 2011

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Gene expression profiling has identified two major molecular subtypes of diffuse large B-cell lymphoma (DLBCL) that are histologically indistinguishable but differ in cure rates. Here, we investigated whether the isotype of the B-cell receptor (BCR) expressed by the tumoral cells correlated with the molecular subtype and survival. Gene expression analysis clustered the 53 patients included in this study into three subgroups, 17 germinal center B-cell-like (GCB) cases, 26 activated B-celllike (ABC) cases and 10 intermediate cases. The molecular subtype was correlated with the isotype, as 15/17 GCB cases expressed a secondary isotype (immunoglobulin (Ig)G or IgA), whereas 24/26 ABC cases expressed a primary isotype (IgM or IgD) (Po0.0001). There was a trend toward a worse outcome for patients with an ABC DLBCL and a shorter overall survival for patients with IgM þ tumor (P ¼ 0.21 and 0.014, respectively). Finally, fluorescence in situ hybridization (FISH) analysis revealed a striking asymmetric pattern, as the IGHM gene is conserved only on the productive IGH allele in most IgM þ tumors. Taken together, these data indicate that the isotype of the BCR is a reliable indicator for the GCB and ABC subtypes in DLBCL, and suggest that the conservation of an IgM is required for ABC DLBCL lymphomagenesis to occur.

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Section: Discussionsupporting

confidence: 84%

The isotype of the BCR as a surrogate for the GCB and ABC molecular subtypes in diffuse large B-cell lymphoma

et al. 2011

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“…An aggressive course of primary testicular T-cell lymphoma has been reported by other studies too (2,3,5,6). Despite of aggressive treatment with high-dose chemotherapy and autologous stem cell transplantation as salvage therapy in this patient, the patient experienced a short-term relapse in the leptomeninges.…”

Section: Discussionsupporting

confidence: 56%

Orbital Infiltration as the First Site of Relapse of Primary Testicular T-cell Lymphoma

et al. 2007

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“…According to our observations and those of previous investigators [6,9,11,14], primary testicular DLBL occurs chiefly in older men (usually from the sixth decade and older) and almost invariably shows significant infiltration in the walls of seminiferous tubules. In contrast, the testicular relapses of lymphoblastic leukemia typically occur in young patients and show an interstitial infiltration pattern with preservation of the tubules in between the leukemia infiltration [35]. The secondary testicular lymphoma (transformed FCL) in this case occurred in a 45-year-old man and showed an interstitial infiltration pattern with wellpreserved tubules in between the lymphoma infiltration.…”

Section: Discussionmentioning

confidence: 67%

“…These lymphomas can involve testis either primarily without previous disease elsewhere or secondarily following lymphoma involvement in other body sites [6,9,11,24,27,30,35,37].…”

Section: Introductionmentioning

confidence: 99%

Testicular diffuse large cell lymphoma with tubule preservation - molecular genetic evidence of transformation from previous follicular lymphoma

2000

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Testicular lymphomas usually occur in older men and are mostly diffuse large B-cell lymphomas (DLBL). They may be primary manifestation of lymphoma or represent a relapse of a previous non-Hodgkin's lymphoma. This report details a testicular large cell lymphoma, which was proven to be large cell transformation of a low-grade follicular lymphoma biopsied 8 years earlier. Initially, a 38-year old man was diagnosed with cervical lymphadenopathy, and biopsy was interpreted as reactive follicular hyperplasia; no treatment was given, and the lymphadenopathy resolved spontaneously. Eight years later, the patient underwent surgery for a left testicular mass and gastroscopy for gastric symptoms. The patient died 7 months later with evidence for intra-abdominal and central nervous system lymphoma after a brief but temporary response to M-BACOD chemotherapy. Orchiectomy specimen and gastroscopic biopsy showed diffuse large B-cell lymphoma (CD20+), which infiltrated between well-preserved tubules in the testis. Histological comparison with 20 testicular lymphomas without previous lymphoma showed tubule infiltration in all cases, suggesting that the tubule-preserving infiltration pattern could be a histological marker for secondary lymphoma involvement in testis. On re-examination, the lymph node 8 years prior was verified as follicular, predominantly small, cleaved cell lymphoma with bcl2-positive follicles. The earlier follicular lymphoma and the subsequent diffuse large cell lymphoma were analyzed using polymerase chain reaction and showed identical sequences of the t(14;18) translocation and immunoglobulin heavy chain gene rearrangement. Analysis of the VH-gene sequences from the follicular lymphoma revealed sequence heterogeneity consistent with ongoing mutation. However, the transformed diffuse large cell lymphoma had no intraclonal variation, with the sequence matching with one of the subclones from the low-grade follicular lymphoma. These results confirm that the large cell transformation of follicular lymphoma occurs in a single follicular lymphoma cell. This case also indicates that the selection of the transformed clone can be part of the natural history of disease and can occur without exposure to chemotherapy.

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Morphological and immunohistological study of testicular lymphomas

Cited by 37 publications

References 19 publications

The isotype of the BCR as a surrogate for the GCB and ABC molecular subtypes in diffuse large B-cell lymphoma

The isotype of the BCR as a surrogate for the GCB and ABC molecular subtypes in diffuse large B-cell lymphoma

Orbital Infiltration as the First Site of Relapse of Primary Testicular T-cell Lymphoma

Testicular diffuse large cell lymphoma with tubule preservation - molecular genetic evidence of transformation from previous follicular lymphoma

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