Morphological and mechanical characterization of composite bone cement containing polymethylmethacrylate matrix functionalized with trimethoxysilyl and bioactive glass

Puska, Mervi; Moritz, Niko; Aho, A. J.; Vallittu, Pekka K.

doi:10.1016/j.jmbbm.2015.12.016

Cited by 22 publications

(9 citation statements)

References 39 publications

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“…Nevertheless, bone substitute research is a fast growing area . Primary pursued goals are the enhancement of osseointegration and bone ingrowth capacity, adequate mechanical resistance, resorbability, and injectability . Porous structure improves integration with the bone and accelerates reabsorption.…”

Section: Discussionmentioning

confidence: 99%

“…1 Primary pursued goals are the enhancement of osseointegration and bone ingrowth capacity, adequate mechanical resistance, resorbability, and injectability. 1,5,[29][30][31][32][33] Porous structure improves integration with the bone and accelerates reabsorption. In addition, porosity decreases resistance and increases elasticity of rigid cement bases, resembling trabecular bone.…”

Section: Discussionmentioning

confidence: 99%

“…Poly(methyl methacrylate) (PMMA) displays early mechanical resistance, unlimited disposability, and biocompatibility. In addition, this low‐cost bone substitute shows plasticity and easy manipulation in the operating room, being the most popular since the 1970s …”

Section: Introductionmentioning

confidence: 99%

“…In addition, this low-cost bone substitute shows plasticity and easy manipulation in the operating room, [1][2][3][4] being the most popular since the 1970s. 5 Nonetheless, loosening of PMMA is a frequent drawback observed at the radiographies by the formation of a radiolucent area around blocks. 6,7 Baptista et al by reviewing radiographies of giant cell tumor patients 10 years after implantation of solid cement found that subchondral cement blocks are eight times more likely to develop osteoarthrosis than metaphyseal implantations.…”

Section: Introductionmentioning

confidence: 99%

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Safety, osseointegration, and bone ingrowth analysis of PMMA‐based porous cement on animal metaphyseal bone defect model

et al. 2017

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Bone defects created after curettage of benign bone tumors are customarily filled with solid poly(methyl methacrylate) (PMMA) or other bone substitutes. In this study, we depicted a porous PMMA-based cement (produced by mixing sodium bicarbonate and citric acid) and evaluated the prospect of its clinic application. Cement samples were characterized by high-performance liquid chromatography (HPLC) coupled to mass spectrometry and its cytotoxicity evaluated in fibroblast cultures. Implantation in rabbits allowed the histologic analysis of bone, kidneys, and liver for toxicity and coagulation tests, and MRI images for hemostasis evaluation. Osseointegration was analyzed through radiography, microtomography (micro-CT), SEM, and histology of sheep specimens. Rabbit specimens were analyzed 1, 4, and 7 days after implantation of porous or solid bone cement in 6.0 mm femoral defects. Sheep specimens were analyzed 3 and 6 months after implantation or not of porous or solid cement in 15.0 mm subchondral tibial defects. The production process did not release any detectable toxic substance but slightly reduced fibroblast proliferation in vitro. Until 7 days after surgery, no local or systemic alterations could be detected in histology, or hematoma formation in histology or MRI. Sheep implants showed 6 mm linear ingrowth from the bone-cement interface and 20% bone ingrowth considering the whole defect area. Radiography, micro-CT, SEM, and histology confirmed these findings. We conclude that our porous PMMA-based cement is an attractive alternative treatment for bone defect filling that combines osseointegration and early weight bearing. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 649-658, 2018.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Safety, osseointegration, and bone ingrowth analysis of PMMA‐based porous cement on animal metaphyseal bone defect model

et al. 2017

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“…Percutaneous is performed under the radiological assistance and the radiopaque agent in BC helps to monitor the placing of material. The vertebroplasty is an advance technique to practice the restoration of vertebral function by injecting BC for the conditions like osteoporosis, vertebral compression fracture, myelomas, scoliosis, and kyphosis (Ajaxon & Persson, ; Anselmetti, Muto, Guglielmi, & Masala, ; Arora, Chan, Gupta, & Diwan, ; Baleani, Cristofolini, Minari, & Toni, ; Burton, Rhines, & Mendel, ; Chen et al, ; Goto et al, ; Jasper, Deramond, Mathis, & Belkoff, ; Kapusetti, Misra, Singh, Kushwaha, & Maiti, ; Kim et al, ; McGraw et al, ; Miyazaki et al, ; Mousa et al, ; Puska, Moritz, Aho, & Vallittu, ).…”

Section: Introductionmentioning

confidence: 99%

Detoxification of poly(methyl methacrylate) bone cement by natural antioxidant intervention

Choppadandi

Kapusetti

2019

J Biomedical Materials Res

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Poly(methyl methacrylate) (PMMA) bone cement is the most widely used grouting material in the joint arthroplasties and vertebroplasties. The present investigation has been carried out to scavenge the radicals and monomer by addition of an antioxidant to minimize the toxicity of bone cement (BC). The in silico studies were employed to determine the potent natural antioxidant at physiological conditions. The antioxidant methionine demonstrated a strong binding affinity with free radicals and methyl methacrylate (MMA) monomer than cysteine. The designated amount of methionine was optimized by various assay methods and >2% methionine shows strong scavenging capacity in BC. Moreover, the antioxidant‐loaded BC (ABC) demonstrated similar handling, physicochemical and mechanical properties to pristine bone cement. Significantly, the developed formulation shows superior biological characteristics such as cell proliferation (2 ± 1 BC and 6 ± 1 ABC), adhesion (0.32 ± 0.02 BC and 0.54 ± 0.01 ABC), and cell viability (81 ± 2% BC and 93 ± 1% ABC) toward human osteoblast‐like cells (MG‐63). Therefore, the novel antioxidant bone cement is a potential candidate for various orthopedic applications to eliminate the adverse effects, related to residual toxic radical and monomer in bone cement.

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Integrating Phosphate Enhances Biomineralization Effect of Methacrylate Cement in Vital Pulp Treatment with Improved Human Dental Pulp Stem Cells Stimulation

Ryu,

Mangal,

Kwon

et al. 2024

Adv Healthcare Materials

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Vital pulp treatment (VPT) is crucial for preserving the health and function of the tooth in cases where the pulp tissue remains vital despite exposure. Various materials are introduced for this purpose. However, challenges such as low strength, high solubility, and tooth discoloration persist. Methylmethacrylate‐based cement (MC) offers excellent sealing ability, feasibility, and mechanical properties, making it a promising alternative for VPT. Phosphate‐based glass (PBG) has the potential to promote hard tissue regeneration by releasing key inducers, phosphorus (P) and calcium (Ca), for reparative odontogenesis. This study investigates PBG‐integrated MC (PIMC) by characterizing its properties, assessing human dental pulp stem cell activity related to initial inflammatory adaptation and odontogenic differentiation, and evaluating hard tissue formation using an in vivo dog pulpotomy model. Results indicate that a 5% PBG‐integrated MC (5PIMC) maintains the physicochemical properties of MC. Furthermore, 5PIMC demonstrates cytocompatibility, excellent expression of osteo/odontogenic markers, and resistance to inflammatory markers, significantly outperforming MC. Enhanced hard tissue formation is observed in the dental pulp of mongrel dog teeth treated with 5PIMC. These findings suggest that 5PIMC could be an optimal and suitable material for reparative odontogenesis through VPT.

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Morphological and mechanical characterization of composite bone cement containing polymethylmethacrylate matrix functionalized with trimethoxysilyl and bioactive glass

Cited by 22 publications

References 39 publications

Safety, osseointegration, and bone ingrowth analysis of PMMA‐based porous cement on animal metaphyseal bone defect model

Safety, osseointegration, and bone ingrowth analysis of PMMA‐based porous cement on animal metaphyseal bone defect model

Detoxification of poly(methyl methacrylate) bone cement by natural antioxidant intervention

Integrating Phosphate Enhances Biomineralization Effect of Methacrylate Cement in Vital Pulp Treatment with Improved Human Dental Pulp Stem Cells Stimulation

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