Cheese mites environment infestations have been recurrent and well‐known for a long time. Nevertheless, studies aiming to evaluate consumption safety have not yet been conducted, causing legislation in many countries to prohibit and destroy this type of product when detected. Here, we evaluated whether feeding upon cheeses ripened with Tyrophagus putrescentiae (Acari: Acaridae) mites would impair the physiological status of non‐immunosuppressed and immunosuppressed (cyclophosphamide‐treated) mice. Our results revealed the absence of any detrimental effects of eating mite‐ripened cheeses, which can support the advancements in the regularisation of cheeses ripened with mites.