Morphological and radiometrical study of the human intervertebral foramina of the cervical spine

Ahmed, Sonia; El-Shaarawy, Ehab Aa; Ishaq, M. F.; Moniem, M. H. Abdel

doi:10.5603/fm.2014.0002

Cited by 5 publications

(4 citation statements)

References 29 publications

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“…Ahmed et al reported the morphology of the human intervertebral foramina of the cervical spine. 21 There were no significant differences between the right and the left sides from C3-C4 to C6-C7 intervertebral levels. 21 Therefore, patients with wide WIF at the C4-C5 and C5-C6 intervertebral levels on the normal side originally tend to have wide WIF at the C4-C5 and C5-C6 intervertebral levels on the affected side.…”

Section: Factors Associated With Group 1 Statusmentioning

confidence: 75%

“…21 There were no significant differences between the right and the left sides from C3-C4 to C6-C7 intervertebral levels. 21 Therefore, patients with wide WIF at the C4-C5 and C5-C6 intervertebral levels on the normal side originally tend to have wide WIF at the C4-C5 and C5-C6 intervertebral levels on the affected side. We considered that WIF at the C4-C5 and C5-C6 intervertebral levels on the affected side may have become narrower due to degenerative changes.…”

Section: Factors Associated With Group 1 Statusmentioning

confidence: 75%

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Factors associated with an excellent outcome after conservative treatment for patients with proximal cervical spondylotic amyotrophy using electrophysiological, neurological and radiological findings

Imajo

Kanchiku

Suzuki

et al. 2019

The Journal of Spinal Cord Medicine

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Section: Factors Associated With Group 1 Statusmentioning

confidence: 75%

Section: Factors Associated With Group 1 Statusmentioning

confidence: 75%

Factors associated with an excellent outcome after conservative treatment for patients with proximal cervical spondylotic amyotrophy using electrophysiological, neurological and radiological findings

Imajo

Kanchiku

Suzuki

et al. 2019

The Journal of Spinal Cord Medicine

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“…17 Other studies have focused on the use of oblique radiographs to best capture the IVF; [18][19][20] however, these studied the cervical foramina, and there are minimal studies involving oblique radiographs of the lumbar foramina. Cervical and lumbar anatomy, particularly at the IVF, also have significant differences in the position of nerve roots relative to the disc plane and the percentage of neural tissue occupying the foraminal space, 21,22 which may influence the impact of vertebral osteophytes on nerve impingement. In addition, patients in our cohort rarely had oblique lumbar radiographs available, rendering these measurement approaches obsolete.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Posterior Intervertebral Osteophytes on Patient-Reported Outcome Measures After L5-S1 Anterior Lumbar Interbody Fusion and Transforaminal Lumbar Interbody Fusion

Zhao,

Hirase,

Kim

et al. 2024

Spine

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Study Design. Retrospective cohort study Objective. (1) To develop a reliable grading system to assess the severity of posterior intervertebral osteophytes and (2) to investigate the impact of posterior intervertebral osteophytes on clinical outcomes following L5-S1 decompression and fusion via anterior lumbar interbody fusion (ALIF) and minimally-invasive transforaminal lumbar interbody fusion (MIS-TLIF). Summary of Background Data. There is limited evidence regarding the clinical implications of posterior lumbar vertebral body osteophytes for ALIF and MIS-TLIF surgeries and there are no established grading systems that defines the severity of these posterior lumbar intervertebral osteophytes. Methods. A retrospective analysis of patients undergoing L5-S1 ALIF or MIS-TLIF was performed. Preoperative and postoperative patient-reported outcome measures (PROMs) of Oswestry Disability Index (ODI) and Leg Visual Analog Scale (VAS) at 2-week, 6-week, 12-week, and 6-month follow-up time points were assessed. Minimal clinically important difference (MCID) for ODI of 14.9 and VAS leg of 2.8 were utilized. Osteophyte grade was based on the ratio of osteophyte length to foraminal width. “High-grade” osteophytes were defined as a maximal osteophyte length greater than 50% of the total foraminal width. Results. 70 consecutive patients (32 ALIF, 38 MIS-TLIF) were included in the study. There were no significant differences between the two cohorts in PROMs or achievement of MCID for Leg VAS or ODI preoperatively or at any follow-ups. On multivariate analysis, neither the surgical approach nor the presence of high-grade foraminal osteophytes were associated with leg VAS or ODI scores at any follow-up timepoint. Additionally, neither the surgical approach nor the presence of high-grade foraminal osteophytes were associated with achievement of MCID for leg VAS or ODI at 6 months. Conclusion. ALIF and MIS-TLIF are both valid options in treating degenerative spine conditions and lumbar radiculopathy, even in the presence of high-grade osteophytes that significantly occupy the intervertebral foramen. Level of Evidence. 3

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“…Imbalances between apoptosis and regeneration cause the regression of the intervertebral disc (1). Apoptosis is as essential as the function of proteoglycan synthesis in determining the possible degeneration of intervertebral discs.…”

Section: Introductionmentioning

confidence: 99%

Protective effects of paeoniflorin against FasL-induced apoptosis of intervertebral disc annulus fibrosus cells via Fas-FasL signalling pathway

Chen

Lin

Zheng

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. In the present study, we demonstrate that the degeneration of intervertebral discs is caused by ageing and apoptosis of matrix cells. Apoptosis is as essential as the function of proteoglycan synthesis in assessing the possible degeneration of intervertebral discs; paeoniflorin (PF) induces cytoprotective effects on various types of cells. In this study, the function of PF in inhibiting Fas ligand (FasL)-induced apoptosis in annulus fibrosus cells was assessed, and the correlation between apoptosis and the Fas-FasL pathway was determined. Annulus fibrosus cells were derived from the intervertebral discs of 1-month-old Sprague Dawley rats; the cells were characterised by toluidine blue staining and subjected to apoptosis with FasL. PF was diluted to various concentrations and added to annulus fibrosus cells at various times. The impact of PF and FasL on cell apoptosis of annulus fibrosus cells was determined by flow cytometry. Western blot analysis was performed to determine the protein expression levels of Fas and caspase-3. The percentages of apoptotic annulus fibrosus cells as well as the expression levels of caspase-3 and Fas were significantly reduced following treatment with 208, 20.8 or 2.08 µM PF. PF inhibits the activation of the Fas-FasL signal pathway and decreases FasL-induced apoptosis of annulus fibrosus cells.

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Morphological and radiometrical study of the human intervertebral foramina of the cervical spine

Abstract: (Folia Morphol 2014; 73, 1: 7-18)

Cited by 5 publications

References 29 publications

Factors associated with an excellent outcome after conservative treatment for patients with proximal cervical spondylotic amyotrophy using electrophysiological, neurological and radiological findings

Factors associated with an excellent outcome after conservative treatment for patients with proximal cervical spondylotic amyotrophy using electrophysiological, neurological and radiological findings

The Impact of Posterior Intervertebral Osteophytes on Patient-Reported Outcome Measures After L5-S1 Anterior Lumbar Interbody Fusion and Transforaminal Lumbar Interbody Fusion

Protective effects of paeoniflorin against FasL-induced apoptosis of intervertebral disc annulus fibrosus cells via Fas-FasL signalling pathway

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