Purpose: To perform a comparative morphological analysis of the intermuscular nerve plexus of the book of the Edilbaev breed sheep in postnatal ontogenesis.Materials and methods. For the experiment, the control and experimental groups were selected in the amount of 35 heads, 5 animals were killed immediately after birth. The rest were divided into control and experimental groups of 5 lambs each. Control groups of lambs were fed naturally on ewes. Experimental groups of lambs, according to the instructions, were on artificial feeding with a sheep milk substitute (ZOM) "Kolvo-Start". The object of histological examination was the ganglia of the book of Edilbaev breed lambs of 4 technological periods: newborns, 15-day-old, 2.5-month-old, 4.5-month-old. We used classical neuromorphological, morphometric and histological methods, as well as processing statistical data.Results. Comparative analysis showed that in the group of medium-sized cells in the ganglia of lambs of 2.5 months of age, there is an intensive growth of the cytoplasm in relation to the nucleus, both in the control and in the experiment. The morphological indicators of the adaptive-compensatory restructuring of the nervous tissue were revealed.Conclusion. The obtained morphometric data from birth to 4.5 months of age testify to the advanced growth of ganglia in the experiment both in length and width, an increase in the linear dimensions of the ganglia of the book occurs. This is due to the pronounced adaptation and formation of the organ in connection with the nature of feeding.