Morphological aspects of the vasculogenesis and angiogenesis during prenatal edification of the circle of Willis: a review

Dumitrescu, Ana María; Costea, Claudia Florida; Furnica, Cristina; Turliuc, Mihaela Dana; Cucu, Andrei; Bogdănici, Camelia Margareta; Turliuc, Şerban; Dumitrescu, Gabriela; Sava, Anca

doi:10.47162/rjme.62.3.04

Cited by 9 publications

(10 citation statements)

References 27 publications

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“…In agreement with this concept, the mean of the MVD in this study was significantly high in early stages with tumor size T1 or T2, both inside and outside the tumor, but no correlation was detected when the tumor was in T3 or T4 and when there was LN involvement. A number of authors demonstrated no connection between the MVD value and the clinicopathological factors [18,22,27], nevertheless, many others have shown a strong association between the two [23,28]. This study showed that the percentage of patients with high tumor budding was more than those with intermediate and low tumor budding.…”

Section: Discussionmentioning

confidence: 63%

Mesenchymal and Vascular Dissemination Markers, Erythroblastosis Virus E26 Oncogene Homolog (ERG) and Alpha Smooth Muscle Actin (α-SMA), in Colorectal Cancer and Adjacent Tissue, Pericytes or Microvascular Density

Haji,

Ilias

2023

Cureus

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The harmony between malignant cells and the adjacent microenvironment is a sophisticated subject; however, it seems to play an important role in cancer evolution. This study aimed to assess the microvascular density (MVD) and the mean pericyte number in the tumor and adjacent tissue, and to correlate the results with special histopathological prognostic variables of the tumor. The study included 48 colorectal cancer (CRC) cases diagnosed in the central lab of Duhok. The immunohistochemical (IHC) expressions of the mesenchymal and vascular dissemination markers, erythroblastosis virus E26 oncogene homolog (ERG, a member of the ETS family of transcription factors) and alpha smooth muscle actin (α-SMA) for microvascular density and pericytes, were assessed in tumor cells and in adjacent tissue around the tumor and then correlated to clinicopathological variables with a special concentration on inflammatory reaction, tumor budding, tumor deposition, and lymphovascular invasion. The results showed that the MVD was significantly higher outside the tumor in T1 and T2 compared with T3 and T4. Moreover, it was significantly higher in grade I when compared to grades II and III within the tumor. However, no correlation was found between the MVD and the special histopathological variables that had been studied. On the other hand, the low mean pericyte showed multiple significant associations outside tumor areas, with special histopathological features including a severe inflammatory reaction, a positive tumor deposit, and a negative lymphovascular invasion. These findings may indicate that defective or transformed pericytes around the tumor can participate in the development of the tumor and, subsequently, the outcome and prognosis.

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Section: Discussionmentioning

confidence: 63%

Mesenchymal and Vascular Dissemination Markers, Erythroblastosis Virus E26 Oncogene Homolog (ERG) and Alpha Smooth Muscle Actin (α-SMA), in Colorectal Cancer and Adjacent Tissue, Pericytes or Microvascular Density

Haji,

Ilias

2023

Cureus

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“…Type 14 (hypoplastic A1 segment of ACA and hypoplastic contralateral PComA) was within the same values reported by the above authors, but type 18 (bilateral hypoplastic PComAs and bilateral hypoplastic A1 segments of ACAs) was identified in much lower percentage than in the other published series (Table 4 ). Also, in our series, we identified a much higher percentage of other new configurations which can be the results of some changing in the microenvironment during the embryogenesis [ 50 ], may be due to some particular living conditions of the population in this region of our country.…”

Section: Discussionmentioning

confidence: 98%

Anatomical study of circle of Willis on fresh autopsied brains. A study of a Romanian population

Dumitrescu

Eva²,

Haba³

et al. 2022

Rom J Morphol Embryol

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Because the circle of Willis (CoW) supplies blood to the brain in case of occlusion of one of the cerebral arteries, identification of any change in its classical shape could be useful in the assessment of cerebrovascular morbidity. The purpose of our research was to study the anatomical variants of CoW identified on fresh brains obtained at the clinical autopsies of adult deceased patients belonging to a specific population (Northeastern region of Romania), as no data are available for Romania population up to date. The study group included consecutive patients who died in Prof. Dr. Nicolae Oblu Emergency Clinical Hospital, Iaşi, Romania, due to medical causes between January 1, 2014 and June 30, 2016, to whom a clinical autopsy was performed. From a total of 96 circles of Willis, 29.17% presented an atypical morphology. We identified eight types of anatomical variants, which affected simultaneously both the posterior and the anterior parts of CoW in 46.42% of cases. The most frequent anatomical variants were hypoplasia (20.91%), followed by the absence of an artery (3.06%), and partially fetal type artery (2.04%). 67.86% of atypical CoW exhibited more than one anatomical variant of an artery in one circle. We identified nine of the 23 morphological patterns that were published to date, and also nine new types. Our research proved that in the population living in the Northeastern part of Romania the anatomical variations of circles of Willis are very polymorphic, with particular morphological aspects.

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“…El desarrollo del sistema circulatorio para el suministro de sangre al futuro cerebro comienza con la formación de los seis pares de arterias de los arcos faríngeos primitivos en la etapa embrionaria de 1.3 mm, que posteriormente se someten a cambios durante el desarrollo embrionario (8). Las arterias de los arcos faríngeos se conocen como arcos aórticos, y se denominan del primero al sexto arco aórtico.…”

Section: Embriología Del Polígono De Willisunclassified

“…A partir del tercer arco aórtico se originan las arterias carótidas comunes y las porciones proximales de las arterias carótidas internas. Las porciones distales de las arterias carótidas internas derivan de las extensiones craneales de las aortas dorsales derecha e izquierda (8). Alrededor del día 28 de desarrollo embrionario, la arteria carótida interna se ramifica en la división anterior y posterior.…”

Section: Embriología Del Polígono De Willisunclassified

Variantes anatómicas del segmento anterior del polígono de Willis: relación con aneurismas cerebrales

Zamora-Chavarría,

Herrera-Guerra,

Quesada Navarro

et al. 2023

Rev.méd.sinerg.

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El polígono de Willis es una red vascular que aporta sangre al cerebro y a las estructuras circundantes. Una de sus principales funciones es mantener la irrigación a través de las anastomosis, cuando se presenta alguna condición que compromete el flujo de alguna de sus ramas. Está compuesto por las arterias cerebral anterior, comunicante anterior, carótida interna, cerebral posterior y comunicante posterior. Su conformación varía en la población. Más del 30-60% de las personas presentan una composición distinta a la habitual, siendo la hipoplasia de uno o más vasos la variante anatómica más común. Esta se define como la existencia de menos de 1 mm de calibre externo en la comunicante anterior y cerebral posterior, y los segmentos arteriales A1 de la cerebral anterior y P1 de la cerebral posterior. La arteria cerebral posterior es la que se encuentra hipoplásica con mayor frecuencia, seguida del segmento P1 de la cerebral posterior, el segmento A1 de la cerebral anterior y la comunicante anterior. La formación de aneurismas intracraneales es más frecuente en la arteria comunicante anterior. Se han determinado como factores de riesgo para su aparición el predominio unilateral del tronco de la arteria cerebral anterior, la aplasia/hipoplasia del segmento A2, y la hipoplasia del segmento A1. Esta última variante constituye el principal factor riesgo para la ruptura de los aneurismas intracraneales de la arteria comunicante anterior, ya que aumenta el flujo sanguíneo en el lado opuesto y, con ello, provoca un incremento de la presión intramural que favorece el desarrollo del aneurisma.

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Morphological aspects of the vasculogenesis and angiogenesis during prenatal edification of the circle of Willis: a review

Cited by 9 publications

References 27 publications

Mesenchymal and Vascular Dissemination Markers, Erythroblastosis Virus E26 Oncogene Homolog (ERG) and Alpha Smooth Muscle Actin (α-SMA), in Colorectal Cancer and Adjacent Tissue, Pericytes or Microvascular Density

Mesenchymal and Vascular Dissemination Markers, Erythroblastosis Virus E26 Oncogene Homolog (ERG) and Alpha Smooth Muscle Actin (α-SMA), in Colorectal Cancer and Adjacent Tissue, Pericytes or Microvascular Density

Anatomical study of circle of Willis on fresh autopsied brains. A study of a Romanian population

Variantes anatómicas del segmento anterior del polígono de Willis: relación con aneurismas cerebrales

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