Morphological basis of sensory neuropathy and neuroimmunomodulation in minor salivary glands of patients with Sjögren’s syndrome

Batbayar, Bayarchimeg; Nagy, Gábor; Kövesi, G; Zelles, T; Fehér, Erzsébet

doi:10.1016/j.archoralbio.2004.02.001

Cited by 28 publications

(21 citation statements)

References 43 publications

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“…Our three examinations (light immunohistochemical, confocal laser microscopic, and electron microscopic) showed that some lymphocytes were also IR for NPY and SP, suggesting that in inflammation these cells produce these neuropeptides and they are active in local immune responses of the stomach. Previously it was demonstrated in other tissues that certain conditions, e.g., inflammation, can induce the secretion and release of different neuropeptides from immunocytes (lymphocytes, macrophages, eosinophils) [18, [38][39][40]. Human monocytes and lymphocytes express the SP gene at both the mRNA and the protein level [41,42], as well as CGRP [43].…”

Section: Discussionmentioning

confidence: 99%

Neuroimmune Link in the Mucosa of Chronic Gastritis with Helicobacter pylori Infection

et al. 2006

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It is suggested that different neuropeptides regulate gastric mucosal integrity and participate in the development of chronic gastritis. The aim of this study was to examine the roles and changes of immunoreactive (IR) nerves and immunocompetent cells in human gastritis. Immunohistochemical, immunocytochemical, and confocal laser microscopic methods were used. All investigated nerve fibers were found in different quantities in the mucosa of both control and gastritis samples. The number of SP, NPY, and VIP IR nerve fibers increased significantly (P < 0.05) in gastritis. No IR immunocompetent cells (lymphocytes, plasma cells, mast cells) were found in the control, however, some showed NPY (16.8%) and SP (9.4%) immunoreactivity in chronic gastritis. The distance between nerve fibers and immunocompetent cells was 200 nm to 1 microm. In conclusion, the increased number of SP, NPY, and VIP IR nerves and IR immunocytes suggests that they participate in development of neurogenic inflammation, repairing processes of chronic gastritis.

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Section: Discussionmentioning

confidence: 99%

Neuroimmune Link in the Mucosa of Chronic Gastritis with Helicobacter pylori Infection

et al. 2006

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“…In fact, both of these neuromediators are present in the lacrimal gland, and changes in their concentration have been demonstrated in the salivary glands of patients with Sjö gren syndrome. 21 A decrease in the circulating levels of NPY also has been described in patients affected by autoimmune diseases, which is in line with the anti-inflammatory role of this neuropeptide. 18,25 In fact, NPY treatment is known 19 to inhibit experimental autoimmune encephalomyelitis, a model of helper T-cell type 1-driven disease, by inhibiting helper T-cell type 1-driven inflammatory responses.…”

Section: Commentmentioning

confidence: 93%

“…[21][22][23][24] These changes are hypothesized to be a cause of salivary fluid flow decrease during Sjö gren syndrome. In fact, a remarkable discrepancy can be observed between the inflammatory involvement of the glands and the decrease in fluid flow.…”

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confidence: 96%

Alterations of Tear Neuromediators in Dry Eye Disease

et al. 2011

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To evaluate tear levels of neuromediators in patients with dry eye disease and to identify statistical correlations with the clinical findings.Methods: Nineteen patients with dry eye disease (Sjö gren syndrome, n=5 patients; non-Sjö gren syndrome, n=10; and ocular cicatricial pemphigoid, n = 4) and 12 healthy volunteers were enrolled. The eyes of all participants were evaluated by slitlamp examination, Schirmer testing, fluorescein staining, and tear film break-up time. Grading of dry eye severity was recorded. Tear samples were collected, and substance P, calcitonin gene-related peptide (CGRP), neuropeptide Y (NPY), vasoactive intestinal peptide, and nerve growth factor (NGF) concentrations were evaluated by enzyme-linked immunoassay and correlated with the clinical findings.Results: Nerve growth factor tear levels were significantly increased in participants with dry eye disease; CGRP and NPY concentrations were significantly decreased when compared with those in healthy participants. Dry eye severity showed a direct correlation with NGF and an inverse correlation with CGRP and NPY tear levels. Nerve growth factor tear levels showed a direct correlation with conjunctival hyperemia and fluorescein staining results, CGRP directly correlated with Schirmer test values, and NPY inversely correlated with tear film break-up time. Subgroup analysis showed that CGRP and NPY but not NGF were changed in autoimmune (ie, Sjö gren syndrome and ocular cicatricial pemphigoid) dry eye disease. Conclusions:The decreased tear levels of NPY and CGRP in dry eye disease are related to impaired lacrimal function, and tear levels of NGF are more closely related to corneal epithelial damage. Our findings suggest that NPY, CGRP, and NGF could become useful markers of dry eye severity.

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“…Stimulation of postganglionar parasympathetic fibres activates the release of acetylcholine together with other transmitters such as substance P, VIP, and ATP. Sympathetic fibres release norepinephrine, NPY, and ATP [136]. Substance P and CGRP co-localize in the ganglia [137].…”

Section: Sjögren Syndromementioning

confidence: 99%

Substance P in Rheumatic Diseases

Seidel

Tsalik²,

Vetter³

et al. 2007

CRR

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Inflammation in many autoimmune syndromes is modulated by the nervous system. This paper reviews important principles of neurogenic inflammation and findings of substance P overexpression in rheumatic diseases. Substance P is a key molecule in activating inflammation after antidromal axoplasmic transport and secretion at the nociceptor. We summarize the results from studies with rheumatoid arthritis, osteoarthritis, psoriatic arthritis, systemic lupus erythematodes, systemic sclerosis, vasculitides, Sjögren syndrome, vasculitides, reflex sympathetic dystrophy, gouty arthritis, fibromyalgia syndrome, chronic fatigue syndrome and degenerative vertebral spine disorders. Although substance P is associated with many of these diseases, selective receptor blockers have not been effective in therapy. In contrast, the nonselective antagonist capsaicin is beneficial in some conditions. We also discuss a novel therapeutic principle with selective serotonin antagonists that may induce a powerful downregulation of neurogenic inflammation.

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Morphological basis of sensory neuropathy and neuroimmunomodulation in minor salivary glands of patients with Sjögren’s syndrome

Cited by 28 publications

References 43 publications

Neuroimmune Link in the Mucosa of Chronic Gastritis with Helicobacter pylori Infection

Neuroimmune Link in the Mucosa of Chronic Gastritis with Helicobacter pylori Infection

Alterations of Tear Neuromediators in Dry Eye Disease

Substance P in Rheumatic Diseases

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