Morphological changes in bone following intramedullary implantation of methyl methacrylate: A morphometrical study of calcium deficiency

Sund, G; Rosenquist, Jan

doi:10.3109/17453678408992318

Cited by 5 publications

(2 citation statements)

References 8 publications

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“…The most likely explanation for bone or turnout necrosis following the introduction of cement is thermal injury. The thermal threshold for bone necrosis ranges in different studies from 48°C to 70°C [10,19,21]. However, it is generally accepted that bone necrosis does not occur when the temperature is below 48°C and between 48°C and 60°C the occurrence of bone necrosis is time dependent.…”

Section: Discussionmentioning

confidence: 99%

An investigation of bone necrosis and healing after cryosurgery, phenol cautery or packing with bone cement of defects in the dog femur

Yun

Kim

Han

et al. 1993

International Orthopaedics

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A corticocancellous core was removed from the lateral condyle of both femurs in 26 skeletally mature dogs. The cavity was treated with cryosurgery, phenol cautery or packing with bone cement. The animals were killed after 1, 4, and 12 weeks in the phenol and cement groups, and also after 24 weeks in the cryosurgery group. The extent of the bone necrosis and healing was assessed in each group. After cryosurgery the extent of necrosis was profound in that the area of damage was 365% compared to the area of the cavity; the depth of necrosis extended between 2.5 and 14 mm, beyond the cavity wall. The effect of phenol was negligible in that only microscopic areas of superficial focal necrosis were found around the cavity wall. Bone cement produced an area of necrosis of 153% compared with the cavity, with a depth of between 1.3 and 2.8 mm. Regeneration in the region of necrosis after cryosurgery was only scanty by 4 weeks, but by 12 weeks considerable areas of regeneration were identified and complete healing was observed by 24 weeks. Regeneration of the necrotized bone produced by bone cement packing was rapid and similar to that of the control specimens. These findings suggest that cryosurgery could play a significant role as a surgical adjunct to curettage in locally aggressive benign bone tumours and in some malignancies. Phenol cautery is not regarded as an adequate treatment after curettage of bone tumours. Although the extent of necrosis was relatively small, packing with bone cement is thought to be a useful choice in benign cases.

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Section: Discussionmentioning

confidence: 99%

An investigation of bone necrosis and healing after cryosurgery, phenol cautery or packing with bone cement of defects in the dog femur

Yun

Kim

Han

et al. 1993

International Orthopaedics

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“…Fosfat tamponu (PBS) içinde %5 flurbiprofen içeren formülasyondan etkin madde salım profili(30) Bu sistemlerin prostetik implant olarak, örneğin prostetik kemik çimentosu gibi kullanımlarında polimerin pişmesi için uygulanan yüksek ısının (polietil metakrilat için 94°C) çevre dokularda nekroza neden olabileceği saptanmıştır(33,34).İmplant oluşumu için uygulanan ısının derecesini düşürmek amacıyla yapılan araştırmalardan Mendez ve ark.`nın (35) polimetil metakrilat (PMMA) veya biyoaktif SiO 2 -CaO-Na 2 O-P 2 O 5 cam materyalleri kullanarak hazırladıkları analjezik etkili fosfosal içeren enjektabl formülasyonların 50-60 o C`de piştiği ve PMMA formülasyonlarından 175 saat, cam içeren formülasyonlardan da 48 saat süreyle in vitro etkin madde salımının sağlandığı tespit edilmiştir. Bu formülasyonların in vivo biyouyumluluk Evren ALĞIN, Tamer BAYKARA 294 testlerinde, sıçanlarda kas içine uygulanmaları sonucu PMMA içerenlerin enjeksiyon bölgesinde enflamasyon oluşturmadığı ancak implant çevresinde fibröz bir tabakanın oluşumuna neden olduğu, biyoaktif cam içerenlerin ise implant çevresinde hafif bir enflamasyona ve tipik fibröz kapsül oluşumuna neden olduğu tespit edilmiştir (35).…”

unclassified

In situ oluşan enjektabl biyoparçalanabilir implant sistemler

Alğin¹

1985

Ankara Universitesi Eczacilik Fakultesi Dergisi

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Improved cortical histology after cementation with a new MMA‐DMA‐IBMA bone cement: An animal study

Nimb

Stürup

Jensen

1993

J. Biomed. Mater. Res.

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The histological response of bone to inert bone wax, conventional polymethylmethacrylate (PMMA), and a new formulation of bone cement, methylmethacrylate/n-decylmethacrylate/isobornylmethacrylate (MMA/DMA/IBMA) was investigated in canine tibial diaphysis. The new formulation of cement is characterized by a reduced exothermic temperature at curing and reduced leakage of chemicals to the adjacent bone. In comparison with bone wax, the MMA/DMA/IBMA bone cement did not differ significantly with respect to periosteal apposition and bone remodeling, although a tendency to inhibit the biological response was encountered. The MMA/DMA/IBMA was clearly superior to PMMA bone cement in respect to both bone necrosis and repair, as well as bone remodeling.

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Morphological changes in bone following intramedullary implantation of methyl methacrylate: A morphometrical study of calcium deficiency

Cited by 5 publications

References 8 publications

An investigation of bone necrosis and healing after cryosurgery, phenol cautery or packing with bone cement of defects in the dog femur

An investigation of bone necrosis and healing after cryosurgery, phenol cautery or packing with bone cement of defects in the dog femur

In situ oluşan enjektabl biyoparçalanabilir implant sistemler

Improved cortical histology after cementation with a new MMA‐DMA‐IBMA bone cement: An animal study

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