Morphological changes in the vaginal epithelium during the oestrous cycle of Calomys callosus (Rodentia, Cricetidae)

Rodrigues, Jean Fábio Torres; Ferro, Eloísa Amália Vieira

doi:10.1590/s0034-71081998000300018

Cited by 6 publications

(3 citation statements)

References 17 publications

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“…The localization of the tumors in the disorganized epithelium can be further appreciated at higher magnifications in Figure 3 b and 3 c . The secretory superficial vaginal epithelium, characterized by globular cells,15 is not only found at the luminal surface but also internally suggesting appearance of epithelial structures with opposite polarity probably caused by the trapping of TC‐1 cells during healing. Because of the epithelial location of these TC‐1‐luc tumors, this protocol was used for immunological studies.…”

Section: Resultsmentioning

confidence: 99%

Analysis of pathologic extent of disease for clinically localized prostate cancer after radical prostatectomy and subsequent use of adjuvant radiation in a national cohort

Schreiber¹,

Rineer²,

Yu³

et al. 2010

Cancer

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BACKGROUND:The Surveillance, Epidemiology, and End Results database was analyzed to explore the pathologic extent of disease for clinically localized prostate cancer after radical prostatectomy as well as the use of adjuvant radiation in this population.METHODS:Identified were patients from 2004 to 2006 with clinically staged T1c‐2cNx‐0M0 prostate adenocarcinoma who underwent radical prostatectomy. All patients had complete clinical and pathologic data. The use of postoperative radiation was recorded. Logistic regression analysis was performed to identify unadjusted and adjusted predictors for extraprostatic disease or positive surgical margins and for adjuvant radiation use.RESULTS:A total of 35,642 patients were identified. For those patients with Gleason 7 (4 + 3) and a prostate‐specific antigen (PSA) level of ≥10.1 ng/mL or Gleason 8 to 10 with any PSA level, the rate of organ‐confined disease with negative surgical margins was found to be <50%. Of those with indications for adjuvant radiation, 11.1% received the treatment.CONCLUSIONS:This large population‐based study detailed the risk of extraprostatic extension and positive surgical margins in a broad setting across multiple regions and communities, as well as the use of adjuvant radiation for these patients. As of 2006, 11.1% of patients who had indications for adjuvant radiation received this treatment, providing a useful baseline for future patterns of care studies. Cancer 2010. © 2010 American Cancer Society.

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Section: Resultsmentioning

confidence: 99%

Analysis of pathologic extent of disease for clinically localized prostate cancer after radical prostatectomy and subsequent use of adjuvant radiation in a national cohort

Schreiber¹,

Rineer²,

Yu³

et al. 2010

Cancer

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“…A leukocyte infiltration, extending from the base to the surface of the epithelial layer is also present. 19 Trophic effects on pituitary glands and reproductive organs…”

Section: Vaginal Smear Cytologymentioning

confidence: 99%

Effects of estrogen-like plant compounds on the vaginal epithelium pituitary, adrenal glands, and uterus of rats

Rodrigues

Moreira

Rossete

et al. 2018

Exp Biol Med (Maywood)

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Plant species with recognized estrogenic activity and widely used by Brazil’s female population to prevent the unpleasant symptoms of menopause were investigated in this work to demonstrate if constituents of taro-inhame ( Colocasia esculenta), cumaru ( Dipteryx odorata), and camapu ( Physalis angulata) have the ability to mimic or interfere with the action of estrogens. Moreover, their potential use as natural sources of estrogen-like substances for hormone replacement therapy was evaluated. (a) In vivo pharmacological assays were conducted to determine the estrogenic effects of D. odorata isoflavone-rich extract, P. angulata physalin-rich extract, and C. esculenta flavonoid glycoside-rich fraction (FG) on endocrine glands and reproductive organs of female rats at three different stages of the life cycle. The protocols consisted of uterotrophic assays and cytological evaluation of vaginal smears to detect mucosa cell alterations correlated with changes in hormone levels in each phase of the estrous cycle of female rats. The results indicated that C. esculenta FG exhibited estrogenic activity in prepubescent, pubescent, and adult ovariectomized female rats, while D. odorata isoflavones only promoted a weight increase in the pituitary gland of prepubescent rats after prolonged treatment and P. angulata physalins induced a weight increment in the adrenal glands of ovariectomized rats. Additionally, C. esculenta exerted a significant effect on the opening of the vaginal canal in prepubescent rats and on vaginal epithelium. Prolonged treatment of ovariectomized rats with FG altered the proportion of different types of vaginal epithelial cells in these animals, suggesting an interference of FG with estrogen levels. Colocasia esculenta FG induced hypertrophy of the uterus and pituitary in ovariectomized rats similar to estradiol. To elucidate the mechanism of action of FG, its effects were compared to those of estradiol and of the selective estrogen receptor modulator raloxifene. The results suggest that the efficacy of C. esculenta FG is mediated by binding to selective estrogen receptors present in each organ and that raloxifene inhibits the mechanism of action of FG in the same way as it inhibits the effects of estradiol. The overall findings indicate that C. esculenta FG mimics the action of estrogens, with reduced harmful effects on specific tissues. Impact statement The results of this work provide preliminary evidence that ovariectomized rats display the vaginal smear cells typical of the estrous phase of mature rats after long-term ingestion of Colocasia esculenta flavonoid glycosides. Moreover, the treatment caused beneficial effects on endocrine and reproductive organs compared to estradiol. The animals did not exhibit significant body weight alterations among the groups, demonstrating the maintenance of standard metabolism and energy balance. The overall findings obtained with the rat model of menopause highlight the importance of dietary consumption of C. esculenta constituents as potential selective estrogen receptor modulators and suggest that they may prevent some of the metabolic disorders related to estrogen deficiency.

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“…These animals are active principally at night and in the early morning (Nowak, 1991). The species C. callosus, has been used in laboratory experiments (Rodrigues and Ferro, 1998) and the effects of familiarity and privation on its behavior have been analyzed Kolde, 1989 andOliveira andAdes, 1993). In this study, the territorial behavior and the formation of hierarchies among C. callosus were observed in a laboratory.…”

Section: Introductionmentioning

confidence: 99%

Study of the social hierarchy and territoriality of Calomys callosus Rengger, 1830 (Rodentia: Cricetidae)

Póvoa

Brandeburgo

2007

Braz. J. Biol.

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The genus Calomys comprises a lot of species distributed throughout South America. The species C. callosus Rengger, 1830 occur in Brazil, been often used in laboratory experiments. This work involved a study of aggressive behavior and dominance, which are aspects related to hierarchy and territoriality, among C. callosus males kept in a laboratory. The establishment of a hierarchy was observed, with the dominant animals controlling the space, food and water, while the remaining animals were confined to a restricted space. The intensity of aggression and variations in the number of attacks declined over time as a result of the formation of the hierarchy. No wounds were observed, probably due to the ritualistic nature of the attacks.Keywords: social hierarchy, territoriality, Calomys callosus. Estudo da hierarquia social e territorialidade em Calomys callosusResumo O genêro Calomys inclui várias espécies encontradas na América do Sul. A espécie C. callosus Rengger, 1830 ocorre no Brasil, sendo freqüentemente utilizada em experimentos de laboratório. Neste trabalho foram estudados, em machos mantidos em laboratório, o comportamento agressivo e a dominância, aspectos relacionados à hierarquia e territorialidade. Foi observado o estabelecimento de hierarquia, com os animais dominantes controlando o espaço, o alimento e a água, ficando os demais confinados em um espaço restrito. A intensidade das agressões e as variações no número de ataques diminuiram com o tempo, uma conseqüência da formação de hierarquia. Não foram observados ferimentos, devido provavelmente à ritualização dos ataques.Palavras-chave: hierarquia social, territorialidade, Calomys callosus.

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Morphological changes in the vaginal epithelium during the oestrous cycle of Calomys callosus (Rodentia, Cricetidae)

Cited by 6 publications

References 17 publications

Analysis of pathologic extent of disease for clinically localized prostate cancer after radical prostatectomy and subsequent use of adjuvant radiation in a national cohort

Analysis of pathologic extent of disease for clinically localized prostate cancer after radical prostatectomy and subsequent use of adjuvant radiation in a national cohort

Effects of estrogen-like plant compounds on the vaginal epithelium pituitary, adrenal glands, and uterus of rats

Study of the social hierarchy and territoriality of Calomys callosus Rengger, 1830 (Rodentia: Cricetidae)

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