Morphological Changes of Ureteropelvic Junction (UPJ) in Case of Congenital Hydronephrosis – Review of Literature

Pugacevska, Daila; Groma, Valērija; Pētersons, Aigars; Melderis, Ivars; Gilis, Ainars

doi:10.2478/chilat-2014-0014

Cited by 3 publications

(7 citation statements)

References 2 publications

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“…Congenital obstruction can lead to poor urine excretion, increase the expansion pressure in the pelvis, compress the renal parenchyma, and cause changes in multiple vascular factors such as angiotensin II in the kidney, then it will cause renal vasoconstriction, promote a further increase of renal vascular resistance and decrease renal function. 10,11 Without timely treatment, congenital hydronephrosis may cause renal failure. So it is extremely important to determine the degree of obstruction and renal function in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

Colour Doppler and Biomarkers Utility for Renal Damage due to Congenital Hydronephrosis

Guo

Chen

Liu

2019

J Coll Physicians Surg Pak

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Congenital hydronephrosis, as one of the most common urinary system abnormalities is often found in children with ureteropelvic junction obstruction. [1][2][3] Finding effective, safe and minimally invasive indicators for congenital hydronephrosis evaluation has become a hotspot in current clinical research. Ultrasonography is an easy-to-use, non-invasive and non-radioactive means of examination that can detect morphological damage of hydronephrosis. However, using grayscale ultra-sonography to distinguish cases of mild hydronephrosis from normal cases showing fullness only, is relatively difficult. [4][5][6] Studies show that the levels of serum biomarkers, such as cystatin C (CysC),  2 -micro-globulin ( 2 -MG) and  1 -microglobulin ( 1 -MG) could be used to effectively evaluate renal function. [7][8] Previous studies find that serum CysC,  2 -MG may be potential biomarkers of obstruction in hydronephrosis. 9 The aim of this study was to evaluate the clinical value of colour doppler combined with serum CysC,  2 -MG and  1 -MG in the evaluation of congenital hydronephrosis, with a view to provide a reference for management of congenital hydronephrosis.

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Section: Discussionmentioning

confidence: 99%

Colour Doppler and Biomarkers Utility for Renal Damage due to Congenital Hydronephrosis

Guo

Chen

Liu

2019

J Coll Physicians Surg Pak

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“…Врожденный гидронефроз характеризуется нарушением оттока мочи из почечной лоханки в мочеточник с последующим расширением чашечно-лоханочной системы и потенциальным повреждением паренхимы почки. Обструкция пиелоуретерального сегмента (ОПУС) является наиболее частой причиной неонатального гидронефроза и развивается вследствие эмбриональных нарушений формирования тканевых структур ПУС [1].…”

Section: обоснованиеunclassified

“…ДУПГ с компьютерной интерпретацией результатов обследования и построением графического изображения процесса динамики объемных изменений лоханки во времени проводилась по методике клиники (Бабанин И.Л., 2011) 1 . В норме максимальное расширение лоханки происходит на 10-й мин после введения диуретика, возвращение к первоначальным размерам -в течение 20-30 мин.…”

Section: методы регистрации исходовunclassified

“…Показатели диуретической пиелоэхографии у детей с разным вариантом нарушения уродинамики верхних мочевых путей Коэффициент адаптации лоханки (К а ) 1,00 ± 0,31 (0,93-1,07) 0,56 ± 0,24 (0,13-0,88) 1,18 (0,87-3,15) 2,85(1,46) Коэффициент эффективности опорожнения лоханки (К о ) 1,00 ± 0,31 (0,93-1,07) 0,45 ± 0,19 (0,16-0,84) 0,30 ± 0,12 (0,08-0,52) 93-6,56) (∆V n ) был более значительным и составлял в среднем 150%, а V i увеличился в 2,5 раза. При ОВ по сравнению с ОГВ величина V i на фоне форсированного диуреза изменяется в большей степени (в 1,7 раза), прирост ∆ V nв среднем на 68,5%.…”

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The Rating System of Urodynamics Upper Urinary Tract in Children under Three Years Old with Congenital Hydronephrosis

et al. 2020

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Background. One of the main reasons for the incorrect differentiation of obstructive and non-obstructive disorders of the upper urinary tract (UUT) is age-related morphofunctional immaturity of the kidney and its structures in children of the first three years of life. Aims to investigate to determine the peculiarities of urodynamic disorders of the UUT in infants with congenital hydronephrosis using diuretic pyeloehography (DРG) method. Methods. There were studied DPG data of 55 patients aged 336 months with unilateral hydronephrosis of IIII grades SFU, which were divided into groups in accordance with the variant of violation of the urodynamics of the UUT (obstructive, obstructive-hypertensive and disadaptive). The variants established according to the parameters of the DPG (transient coefficient PUJ (Kpus), the coefficients of postfurosemide adaptation (Ka) and the efficiency of emptying (Ko) pelvis). The obtained data are compared with the conclusions of morphometric studies of the operated 20 children with ureteropelvic junction obstruction (UPJO). Results. The obstructive-hypertensive variant was determined in 18 patients, obstructive in 20, and disadaptive in 17. The severity of pelvic dysfunction (according to Ka and Ko) did not correlated to the grade of UPJO (according Kpus) in most cases. Intergroup and intragroup variability in the values of the DРG coefficients is confirmed by the results of PUJ and pelvis morphometry. The correlation between hystological modification in the pelvis and DPG parameters was revealed. Obtained data allowed to introduce a new indicator urodynamic indicator of quantitative assessment of functional insufficiency of the UUT. And the score gradation of each DРG coefficient (from 0 to 4 points) in accordance with deviation from the reference values was developed. The total indicator functional insufficiency is expressed by the sum of points (SP) for each coefficient (Ka, Ko, Kpus). When SP is less than 3 points light, 46 moderate, 79 expressed and 1012 severe grade of violation of urodynamics. The severity of dysfunctions of the UUT in 88% of children (n = 15) with a disadaptive variant corresponded to light degree, in 75% of patients (n = 14) with an obstructive-hypertensive variant expressed (50%) and severe (25%) grades. Moderate degree of dysfunction revealed in 65% of patients (n = 13) with an obstructive variant. Conclusion. The severity of urodynamic dysfunction of the UUT in this age group can be determined by the score gradation of the DPG parameters which reflects the functionality of the pelvis/PUJ and the grade of their violation adaptive reactions in response to diuretic.

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“…Histological alteration in kidney like glomerulosclerosis, dilated tubules and dense chronic inflammatory infiltrate have also been noted in many studies. 2,3 Transport of urine from kidney to bladder is an active process based on well coordinated one way peristalsis. It is believed that contraction creating peristaltic wave in the ureter is initiated by cells with pacemaker activity in proximal part of renal calyces.…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical Evaluation Of Neuronal Dysfunction In Pelviureteric Junction Obstruction

Asati,

Gupta,

Asati

et al. 2024

IJLBPR

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Morphological Changes of Ureteropelvic Junction (UPJ) in Case of Congenital Hydronephrosis – Review of Literature

Cited by 3 publications

References 2 publications

Colour Doppler and Biomarkers Utility for Renal Damage due to Congenital Hydronephrosis

Colour Doppler and Biomarkers Utility for Renal Damage due to Congenital Hydronephrosis

The Rating System of Urodynamics Upper Urinary Tract in Children under Three Years Old with Congenital Hydronephrosis

Immunohistochemical Evaluation Of Neuronal Dysfunction In Pelviureteric Junction Obstruction

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