Morphological changes on the free surface of thyroid cells at the hormone secretion by scanning electron microscopy.

Kawada, Jun; Naito, Shinsaku

doi:10.1507/endocrj1954.25.217

Cited by 6 publications

(2 citation statements)

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“…One of the early response of TSH-stimulated thyroid follicular cells is engulfment of colloid material from the follicular lumen into the apical cytoplasm of thyrocytes, in the form of membrane-bound colloid droplets. Administration of TSH to rats pretreated with thyroxin resulted in formation of numerous pseudopods on the apical surface of thyrocytes observed with both transmission and scanning electron microscopes (Ekholm et al, 1975;Kawada and Naito, 1978). This is followed by the appearance of colloid droplets, first in the apical and later in the deeper parts of the cytoplasm (Ekholm et al, 1975).…”

Section: Discussionmentioning

confidence: 97%

“…Experiments in in vitro conditions demonstrated the same effects. Thyroid cells incubated with TSH were characterized by apical pseudopods and intracytoplasmic colloid droplets (Kawada and Naito, 1978;Rocmans et al, 1978). In mice and rats injected with TSH after pretreatment with thyroxin, the percentage of follicular cells containing colloid droplets and the number of droplets in cells gradually increased with increase of the TSH dose (Gerber et al, 1987).…”

Section: Discussionmentioning

confidence: 99%

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Light and electron microscopic study of the thyroid gland in rats exposed to power-frequency electromagnetic fields

Rajkovic

Matavulj

Johansson

2006

Journal of Experimental Biology

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SUMMARY The effect of 50 Hz electromagnetic field (EMF) on thyroid gland was studied using light and transmission electron microscopes. Two-month-old male rats were exposed to an EMF (100-300 μT, 54-160 V m-1) for 4 h a day, 5 days a week for 1 month. A predominance of microfollicles with less colloid content and dilated blood capillaries was found in the EMF group. Stereological counting showed a statistically significant increase of the volume density of follicular epithelium, interfollicular tissue and blood capillaries as well as the thyroid activation index, as compared to the controls. The volume density of colloid significantly decreased. Ultrastructural analysis of thyroid follicular cells in the EMF group revealed the frequent finding of several colloid droplets within the same thyrocyte with the occasional presence of large-diameter droplets. Alterations in lysosomes, granular endoplasmic reticulum and cell nuclei compared to the control group were also observed. Taken together, the results of this study show the stimulative effect of power-frequency EMF on thyroid gland at both the light microscope and the ultrastructural level.

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Section: Discussionmentioning

confidence: 97%